{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:14:15Z","timestamp":1790219655150,"version":"4.1.0"},"reference-count":42,"publisher":"The Company of Biologists","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,15]]},"abstract":"<jats:p>In order to understand the functions of laminins in the renal collecting system, the Lamc1 gene was inactivated in the developing mouse ureteric bud (UB). Embryos bearing null alleles exhibited laminin deficiency prior to mesenchymal tubular induction and either failed to develop a UB with involution of the mesenchyme, or developed small kidneys with decreased proliferation and branching, delayed renal vesicle formation and postnatal emergence of a water transport deficit. Embryonic day 12.5 kidneys revealed an almost complete absence of basement membrane proteins and reduced levels of \u03b16 integrin and FGF2. mRNA levels for fibroblast growth factor 2 (FGF2) and mediators of the GDNF\/RET and WNT11 signaling pathway were also decreased. Furthermore, collecting duct cells derived from laminin-deficient kidneys and grown in collagen gels were found to proliferate and branch slowly. The laminin-deficient cells exhibited decreased activation of growth factor- and integrin-dependent pathways, whereas heparin lyase-treated and \u03b21 integrin-null cells exhibited more selective decreases. Collectively, these data support a requirement of \u03b31 laminins for assembly of the collecting duct system basement membrane, in which immobilized ligands act as solid-phase agonists to promote branching morphogenesis, growth and water transport functions.<\/jats:p>","DOI":"10.1242\/dev.071266","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T11:42:27Z","timestamp":1315568547000},"page":"4535-4544","source":"Crossref","is-referenced-by-count":29,"title":["Renal collecting system growth and function depend upon embryonic \u03b31 laminin expression"],"prefix":"10.1242","volume":"138","author":[{"given":"Dong-Hua","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen K.","family":"McKee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology and Genetics, Rockefeller University, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda","family":"Mernaugh","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Vanderbilt University, Nashville, TN 37232-2358, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Strickland","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology and Genetics, Rockefeller University, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Zent","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Vanderbilt University, Nashville, TN 37232-2358, USA."},{"name":"Department of Medicine, Veterans Affairs Hospital, Nashville, TN 37212-2637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Yurchenco","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042607070606300_R1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00467-006-0239-7","article-title":"Role of fibroblast growth factor receptor signaling in kidney development","volume":"22","author":"Bates","year":"2007","journal-title":"Pediatr. 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Physiol. Renal Physiol."},{"key":"2021042607070606300_R6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1083\/jcb.200307068","article-title":"Laminin gamma1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve","volume":"163","author":"Chen","year":"2003","journal-title":"J. Cell Biol."},{"key":"2021042607070606300_R7","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.145.3.619","article-title":"Laminin polymerization induces a receptor-cytoskeleton network","volume":"145","author":"Colognato","year":"1999","journal-title":"J. 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Cell Biol."},{"key":"2021042607070606300_R11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1073\/pnas.77.1.485","article-title":"Induction of a basement membrane glycoprotein in embryonic kidney: possible role of laminin in morphogenesis","volume":"77","author":"Ekblom","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042607070606300_R12","doi-asserted-by":"crossref","first-page":"L1263","DOI":"10.1152\/ajplung.00180.2002","article-title":"Fibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone","volume":"283","author":"Evans","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042607070606300_R13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/(SICI)1520-6408(1999)24:3\/4<309::AID-DVG14>3.0.CO;2-5","article-title":"Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease","volume":"24","author":"Gattone","year":"1999","journal-title":"Dev. Genet."},{"key":"2021042607070606300_R14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/(SICI)1097-0177(199710)210:2<130::AID-AJA6>3.0.CO;2-H","article-title":"Developmental expression of perlecan during murine embryogenesis","volume":"210","author":"Handler","year":"1997","journal-title":"Dev. Dyn."},{"key":"2021042607070606300_R15","first-page":"F1160","article-title":"Characteristics of papillary collecting duct cells in primary culture","volume":"255","author":"Husted","year":"1988","journal-title":"Am. J. 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Biol."},{"key":"2021042607070606300_R23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1083\/jcb.137.3.685","article-title":"The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform","volume":"137","author":"Miner","year":"1997","journal-title":"J. Cell Biol."},{"key":"2021042607070606300_R24","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1083\/jcb.150.5.1215","article-title":"Regulation of programmed cell death by basement membranes in embryonic development","volume":"150","author":"Murray","year":"2000","journal-title":"J. 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Cell Biol."},{"key":"2021042607070606300_R37","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1523\/JNEUROSCI.5032-04.2005","article-title":"Schwann cell-specific ablation of laminin gamma1 causes apoptosis and prevents proliferation","volume":"25","author":"Yu","year":"2005","journal-title":"J. Neurosci."},{"key":"2021042607070606300_R38","doi-asserted-by":"crossref","first-page":"a004911","DOI":"10.1101\/cshperspect.a004911","article-title":"Basement membranes: cell scaffoldings and signaling platforms","volume":"3","author":"Yurchenco","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2021042607070606300_R39","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.2174\/138161209787846766","article-title":"Developmental and pathogenic mechanisms of basement membrane assembly","volume":"15","author":"Yurchenco","year":"2009","journal-title":"Curr. Pharm. 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