{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:18:13Z","timestamp":1792739893203,"version":"4.5.0"},"reference-count":84,"publisher":"The Company of Biologists","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,15]]},"abstract":"<jats:p>The basement membrane is crucial for epithelial tissue organization and function. However, the mechanisms by which basement membrane is restricted to the basal periphery of epithelial tissues and the basement membrane-mediated signals that regulate coordinated tissue organization are not well defined. Here, we report that Rho kinase (ROCK) controls coordinated tissue organization by restricting basement membrane to the epithelial basal periphery in developing mouse submandibular salivary glands, and that ROCK inhibition results in accumulation of ectopic basement membrane throughout the epithelial compartment. ROCK-regulated restriction of PAR-1b (MARK2) localization in the outer basal epithelial cell layer is required for basement membrane positioning at the tissue periphery. PAR-1b is specifically required for basement membrane deposition, as inhibition of PAR-1b kinase activity prevents basement membrane deposition and disrupts overall tissue organization, and suppression of PAR-1b together with ROCK inhibition prevents interior accumulations of basement membrane. Conversely, ectopic overexpression of wild-type PAR-1b results in ectopic interior basement membrane deposition. Significantly, culture of salivary epithelial cells on exogenous basement membrane rescues epithelial organization in the presence of ROCK1 or PAR-1b inhibition, and this basement membrane-mediated rescue requires functional integrin \u03b21 to maintain epithelial cell-cell adhesions. Taken together, these studies indicate that ROCK1\/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.<\/jats:p>","DOI":"10.1242\/dev.075366","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T12:29:13Z","timestamp":1324384153000},"page":"411-422","source":"Crossref","is-referenced-by-count":71,"title":["ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity"],"prefix":"10.1242","volume":"139","author":[{"given":"William P.","family":"Daley","sequence":"first","affiliation":[{"name":"Graduate program in Molecular, Cellular, Developmental, and Neural Biology, University at Albany, State University of New York, Albany, NY 12208, USA."},{"name":"Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise M.","family":"Gervais","sequence":"additional","affiliation":[{"name":"Graduate program in Molecular, Cellular, Developmental, and Neural Biology, University at Albany, State University of New York, Albany, NY 12208, USA."},{"name":"Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"Centanni","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Gulfo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606330111000_R1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0092-8674(04)00114-X","article-title":"Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD","volume":"116","author":"Baas","year":"2004","journal-title":"Cell"},{"key":"2021042606330111000_R2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0092-8674(03)00938-3","article-title":"Drosophila PAR-1 and 14-3-3 inhibit Bazooka\/PAR-3 to establish complementary cortical domains in polarized cells","volume":"115","author":"Benton","year":"2003","journal-title":"Cell"},{"key":"2021042606330111000_R3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0012-1606(82)90378-5","article-title":"The turnover of basal lamina glycosaminoglycan correlates with epithelial morphogenesis","volume":"90","author":"Bernfield","year":"1982","journal-title":"Dev. 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