{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:15:39Z","timestamp":1792592139585,"version":"4.5.0"},"reference-count":55,"publisher":"The Company of Biologists","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,15]]},"abstract":"<jats:p>Outgrowth and fusion of the lateral and medial nasal processes and of the maxillary process of the first branchial arch are integral to lip and primary palate development. Wnt9b mutations are associated with cleft lip and cleft palate in mice; however, the cause of these defects remains unknown. Here, we report that Wnt9b\u2013\/\u2013 mice show significantly retarded outgrowth of the nasal and maxillary processes due to reduced proliferation of mesenchymal cells, which subsequently results in a failure of physical contact between the facial processes that leads to cleft lip and cleft palate. These cellular defects in Wnt9b\u2013\/\u2013 mice are mainly caused by reduced FGF family gene expression and FGF signaling activity resulting from compromised canonical WNT\/\u03b2-catenin signaling. Our study has identified a previously unknown regulatory link between WNT9B and FGF signaling during lip and upper jaw development.<\/jats:p>","DOI":"10.1242\/dev.075796","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T00:55:54Z","timestamp":1333068954000},"page":"1821-1830","source":"Crossref","is-referenced-by-count":100,"title":["Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development"],"prefix":"10.1242","volume":"139","author":[{"given":"Yong-Ri","family":"Jin","sequence":"first","affiliation":[{"name":"COBRE in Stem Cell and Regenerative Medicine, Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Hua","family":"Han","sequence":"additional","affiliation":[{"name":"COBRE in Stem Cell and Regenerative Medicine, Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto M.","family":"Taketo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida-Kono\u00e9-Cho, Sakyo-Ku, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Kyo","family":"Yoon","sequence":"additional","affiliation":[{"name":"COBRE in Stem Cell and Regenerative Medicine, Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606160437400_R1","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1242\/dev.129.19.4613","article-title":"Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse","volume":"129","author":"Abu-Issa","year":"2002","journal-title":"Development"},{"key":"2021042606160437400_R2","doi-asserted-by":"crossref","first-page":"e23139","DOI":"10.1371\/journal.pone.0023139","article-title":"Contrasting expression of canonical wnt signaling reporters TOPGAL, BATGAL and Axin2 during murine lung development and repair","volume":"6","author":"Al Alam","year":"2011","journal-title":"PLoS ONE"},{"key":"2021042606160437400_R3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/sj.cr.7290185","article-title":"Msx homeobox gene family and craniofacial development","volume":"13","author":"Alappat","year":"2003","journal-title":"Cell Res."},{"key":"2021042606160437400_R4","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1126\/science.1128406","article-title":"SUMO1 haploinsufficiency leads to cleft lip and palate","volume":"313","author":"Alkuraya","year":"2006","journal-title":"Science"},{"key":"2021042606160437400_R5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0925-4773(00)00518-9","article-title":"Expression of members of the Fgf family and their receptors during midfacial development","volume":"100","author":"Bachler","year":"2001","journal-title":"Mech. 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