{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:11:17Z","timestamp":1791925877543,"version":"4.3.4"},"reference-count":34,"publisher":"The Company of Biologists","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:p>Neuronal migration, a key event during brain development, remains largely unexplored in the mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations. Here we study the migrational trajectories of DA and GABA neurons and show that they occupy ventral mesencephalic territory in a temporally and spatially specific manner. Our results from the Pitx3-deficient aphakia mouse suggest that pre-existing DA neurons modulate GABA neuronal migration to their final destination, providing novel insights and fresh perspectives concerning neuronal migration and connectivity in the mesencephalon in normal as well as diseased brains.<\/jats:p>","DOI":"10.1242\/dev.078394","type":"journal-article","created":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T11:24:35Z","timestamp":1344338675000},"page":"3136-3141","source":"Crossref","is-referenced-by-count":17,"title":["Dopaminergic neurons modulate GABA neuron migration in the embryonic midbrain"],"prefix":"10.1242","volume":"139","author":[{"given":"Anju","family":"Vasudevan","sequence":"first","affiliation":[{"name":"Angiogenesis and Brain Development Laboratory, Division of Basic Neuroscience, McLean Hospital\/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chungkil","family":"Won","sequence":"additional","affiliation":[{"name":"Angiogenesis and Brain Development Laboratory, Division of Basic Neuroscience, McLean Hospital\/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA."},{"name":"Molecular Neurobiology Laboratory and Program in Neuroscience, McLean Hospital\/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA."},{"name":"Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyan","family":"Li","sequence":"additional","affiliation":[{"name":"Angiogenesis and Brain Development Laboratory, Division of Basic Neuroscience, McLean Hospital\/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Erd\u00e9lyi","sequence":"additional","affiliation":[{"name":"Institute Of Experimental Medicine, Department Of Gene Technology And Developmental Neurobiology, Laboratory Of Molecular Biology And Genetics, 1083 Budapest, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Institute Of Experimental Medicine, Department Of Gene Technology And Developmental Neurobiology, Laboratory Of Molecular Biology And Genetics, 1083 Budapest, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology Laboratory and Program in Neuroscience, McLean Hospital\/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606264632600_R1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00240955","article-title":"Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse","volume":"105","author":"Bayer","year":"1995","journal-title":"Exp. Brain Res."},{"key":"2021042606264632600_R2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tins.2007.03.006","article-title":"Dopamine neuron systems in the brain: an update","volume":"30","author":"Bj\u00f6rklund","year":"2007","journal-title":"Trends Neurosci."},{"key":"2021042606264632600_R3","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.stem.2009.09.015","article-title":"Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway","volume":"5","author":"Chung","year":"2009","journal-title":"Cell Stem Cell"},{"issue":"Suppl.","key":"2021042606264632600_R4","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/nn749","article-title":"Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain","volume":"4","author":"Corbin","year":"2001","journal-title":"Nat. Neurosci."},{"key":"2021042606264632600_R5","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/brain\/122.8.1437","article-title":"The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson\u2019s disease","volume":"122","author":"Damier","year":"1999","journal-title":"Brain"},{"key":"2021042606264632600_R6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1073\/pnas.1006511108","article-title":"Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice","volume":"108","author":"Ding","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606264632600_R7","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1242\/dev.02557","article-title":"Megane\/Heslike is required for normal GABAergic differentiation in the mouse superior colliculus","volume":"133","author":"Guimera","year":"2006","journal-title":"Development"},{"key":"2021042606264632600_R8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/cne.901420105","article-title":"Histogenesis of the substantia nigra, ventral tegmental area of Tsai and interpeduncular nucleus: an autoradiographic study of the mesencephalon in the rat","volume":"142","author":"Hanaway","year":"1971","journal-title":"J. Comp. Neurol."},{"key":"2021042606264632600_R9","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1126\/science.1074572","article-title":"New directions in neuronal migration","volume":"297","author":"Hatten","year":"2002","journal-title":"Science"},{"key":"2021042606264632600_R10","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1523\/JNEUROSCI.3718-04.2005","article-title":"3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson\u2019s disease","volume":"25","author":"Hwang","year":"2005","journal-title":"J. Neurosci."},{"key":"2021042606264632600_R11","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/1096-9861(20000904)424:4<607::AID-CNE4>3.0.CO;2-C","article-title":"Domain-restricted expression of two glutamic acid decarboxylase genes in midgestation mouse embryos","volume":"424","author":"Katarova","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"2021042606264632600_R12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-3806(95)00018-9","article-title":"Migration of dopaminergic neurons in the embryonic mesencephalon of mice","volume":"86","author":"Kawano","year":"1995","journal-title":"Brain Res. Dev. Brain Res."},{"key":"2021042606264632600_R13","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1140481","article-title":"A MicroRNA feedback circuit in midbrain dopamine neurons","volume":"317","author":"Kim","year":"2007","journal-title":"Science"},{"key":"2021042606264632600_R14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1385\/MN:29:3:243","article-title":"Functional diversity of ventral midbrain dopamine and GABAergic neurons","volume":"29","author":"Korotkova","year":"2004","journal-title":"Mol. Neurobiol."},{"key":"2021042606264632600_R15","doi-asserted-by":"crossref","first-page":"13078","DOI":"10.1523\/JNEUROSCI.1197-11.2011","article-title":"Midbrain dopamine neurons associated with reward processing innervate the neurogenic subventricular zone","volume":"31","author":"Lennington","year":"2011","journal-title":"J. Neurosci."},{"key":"2021042606264632600_R16","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1093\/cercor\/bhh072","article-title":"Preferential origin and layer destination of GAD65-GFP cortical interneurons","volume":"14","author":"L\u00f3pez-Bendito","year":"2004","journal-title":"Cereb. Cortex"},{"key":"2021042606264632600_R17","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1523\/JNEUROSCI.4651-07.2008","article-title":"Chemokine signaling controls intracortical migration and final distribution of GABAergic interneurons","volume":"28","author":"L\u00f3pez-Bendito","year":"2008","journal-title":"J. Neurosci."},{"key":"2021042606264632600_R18","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/35097509","article-title":"A long, remarkable journey: tangential migration in the telencephalon","volume":"2","author":"Mar\u00edn","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042606264632600_R19","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1093\/cercor\/bhp307","article-title":"Nogo-a regulates neural precursor migration in the embryonic mouse cortex","volume":"20","author":"Mathis","year":"2010","journal-title":"Cereb. Cortex"},{"key":"2021042606264632600_R20","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.neuroscience.2008.01.046","article-title":"Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat","volume":"152","author":"Nair-Roberts","year":"2008","journal-title":"Neuroscience"},{"key":"2021042606264632600_R21","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.0230529100","article-title":"Pitx3 is required for development of substantia nigra dopaminergic neurons","volume":"100","author":"Nunes","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606264632600_R22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/syn.20345","article-title":"Topographical organization of GABAergic neurons within the ventral tegmental area of the rat","volume":"61","author":"Olson","year":"2007","journal-title":"Synapse"},{"key":"2021042606264632600_R23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1749-8104-6-26","article-title":"Neuronal migration defects in the Loa dynein mutant mouse","volume":"6","author":"Ori-McKenney","year":"2011","journal-title":"Neural Dev."},{"key":"2021042606264632600_R24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0166-2236(00)01553-8","article-title":"The origin and migration of cortical neurones: new vistas","volume":"23","author":"Parnavelas","year":"2000","journal-title":"Trends Neurosci."},{"key":"2021042606264632600_R25","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1242\/dev.031781","article-title":"Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain","volume":"136","author":"Prakash","year":"2009","journal-title":"Development"},{"key":"2021042606264632600_R26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/107385840100700406","article-title":"Reward signaling by dopamine neurons","volume":"7","author":"Schultz","year":"2001","journal-title":"Neuroscientist"},{"key":"2021042606264632600_R27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/365441a0","article-title":"Dopamine D4 receptors elevated in schizophrenia","volume":"365","author":"Seeman","year":"1993","journal-title":"Nature"},{"key":"2021042606264632600_R28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrn2039","article-title":"How to make a mesodiencephalic dopaminergic neuron","volume":"8","author":"Smidt","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042606264632600_R29","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1242\/dev.01022","article-title":"Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3","volume":"131","author":"Smidt","year":"2004","journal-title":"Development"},{"key":"2021042606264632600_R30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/39.3.1671576","article-title":"Simultaneous immunocytochemical visualization of bromodeoxyuridine and neural tissue antigens","volume":"39","author":"Soriano","year":"1991","journal-title":"J. Histochem. Cytochem."},{"key":"2021042606264632600_R31","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/cercor\/10.6.602","article-title":"Disruption of neuronal migration and radial glia in the developing cerebral cortex following ablation of Cajal-Retzius cells","volume":"10","author":"Sup\u00e8r","year":"2000","journal-title":"Cereb. Cortex"},{"key":"2021042606264632600_R32","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1242\/dev.00464","article-title":"Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons","volume":"130","author":"van den Munckhof","year":"2003","journal-title":"Development"},{"key":"2021042606264632600_R33","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.1523\/JNEUROSCI.5158-04.2005","article-title":"Otx2 regulates subtype specification and neurogenesis in the midbrain","volume":"25","author":"Vernay","year":"2005","journal-title":"J. Neurosci."},{"key":"2021042606264632600_R34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ydbio.2004.09.024","article-title":"Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons","volume":"277","author":"Wines-Samuelson","year":"2005","journal-title":"Dev. Biol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/139\/17\/3136\/1185283\/3136.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/139\/17\/3136\/1185283\/3136.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T08:11:06Z","timestamp":1619424666000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/139\/17\/3136\/45280\/Dopaminergic-neurons-modulate-GABA-neuron"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,1]]},"references-count":34,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2012,9,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.078394","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9,1]]}}}