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Using ex vivo analyses in chick and in vivo analyses in mutant and transgenic zebrafish, we show that Fgf10 and Fgf3 secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons. Simultaneously, they promote hypophyseal vascularisation, exerting early direct effects on endothelial cells that are subsequently complemented by indirect effects. Together, our studies suggest a model for the integrated neurohemal wiring of the hypothalamo-neurohypophyseal axis.<\/jats:p>","DOI":"10.1242\/dev.080226","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T12:19:17Z","timestamp":1360671557000},"page":"1111-1122","source":"Crossref","is-referenced-by-count":42,"title":["Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis"],"prefix":"10.1242","volume":"140","author":[{"given":"Fang","family":"Liu","sequence":"first","affiliation":[{"name":"MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Martin","family":"Pogoda","sequence":"additional","affiliation":[{"name":"Institute for Developmental Biology, Center of Molecular Medicine Cologne (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50674 Cologne, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Alayne","family":"Pearson","sequence":"additional","affiliation":[{"name":"MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK."},{"name":"Department of Neurobiology and Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, CA 90095, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoji","family":"Ohyama","sequence":"additional","affiliation":[{"name":"MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"L\u00f6hr","sequence":"additional","affiliation":[{"name":"Institute for Developmental Biology, Center of Molecular Medicine Cologne (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50674 Cologne, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Hammerschmidt","sequence":"additional","affiliation":[{"name":"Institute for Developmental Biology, Center of Molecular Medicine Cologne (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50674 Cologne, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marysia","family":"Placzek","sequence":"additional","affiliation":[{"name":"MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042607285736900_R1","doi-asserted-by":"crossref","first-page":"a001875","DOI":"10.1101\/cshperspect.a001875","article-title":"Axon guidance molecules in vascular patterning","volume":"2","author":"Adams","year":"2010","journal-title":"Cold Spring Harb. 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