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When Fz2 and\/or Fz7 mutations are combined with mutations in Vangl2, Dvl3, Wnt3a, Wnt5a or Wnt11, an increased frequency of VSDs is observed with Dvl3, Wnt3a and Wnt11; an increased frequency of palate closure defects is observed with Vangl2; and early lethality and enhanced tail shortening are observed with Wnt5a. To assess the signaling pathways that underlie these and other Frizzled-mediated genetic interactions, we used transfected mammalian cells to analyze (1) canonical Wnt signaling induced by all pairwise combinations of the ten mouse Frizzleds and the 19 mouse Wnts and (2) localization of each Frizzled at cell-cell junctional complexes formed by mouse Celsr1, a likely indicator of competence for planar cell polarity signaling. These in vitro experiments indicate that Fz2 and Fz7 are competent to signal via the canonical pathway. Taken together, the data suggest that genetic interactions between Fz2, Fz7 and Vangl2, Dvl3 and Wnt genes reflect interactions among different signaling pathways in developmental processes that are highly sensitive to perturbations in Frizzled signaling.<\/jats:p>","DOI":"10.1242\/dev.083352","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:29:02Z","timestamp":1351124942000},"page":"4383-4394","source":"Crossref","is-referenced-by-count":151,"title":["Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes"],"prefix":"10.1242","volume":"139","author":[{"given":"Huimin","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nini","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Nathans","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA"},{"name":"Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA"},{"name":"Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA"},{"name":"Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606324238200_R1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/dvdy.22101","article-title":"Genetic interaction between Lrp6 and Wnt5a during mouse development","volume":"239","author":"Andersson","year":"2010","journal-title":"Dev. 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