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The emerging FOXG1+\/GSX2+ telencephalic progenitors are then terminally differentiated, resulting in the systematic line-independent generation of FOXP1+\/FOXP2+\/CTIP2+\/calbindin+\/DARPP-32+ MSNs. Similar to mature MSNs, these neurons carry dopamine and A2a receptors, elicit a typical firing pattern and show inhibitory postsynaptic currents, as well as dopamine neuromodulation and synaptic integration ability in vivo. When transplanted into the striatum of quinolinic acid-lesioned rats, hPS-derived neurons survive and differentiate into DARPP-32+ neurons, leading to a restoration of apomorphine-induced rotation behavior. In summary, hPS cells can be efficiently driven to acquire a functional striatal fate using an ontogeny-recapitulating stepwise method that represents a platform for in vitro human developmental neurobiology studies and drug screening approaches.<\/jats:p>","DOI":"10.1242\/dev.084608","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T12:32:43Z","timestamp":1355833963000},"page":"301-312","source":"Crossref","is-referenced-by-count":154,"title":["Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons"],"prefix":"10.1242","volume":"140","author":[{"given":"Alessia Delli","family":"Carri","sequence":"first","affiliation":[{"name":"Center for Stem Cell Research, Universit\u00e0 degli Studi di Milano, 20133 Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Onorati","sequence":"additional","affiliation":[{"name":"Center for Stem Cell Research, Universit\u00e0 degli Studi di Milano, 20133 Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah J.","family":"Lelos","sequence":"additional","affiliation":[{"name":"School of Bioscience, Cardiff University, Cardiff CF10 3AX, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Castiglioni","sequence":"additional","affiliation":[{"name":"Center for Stem Cell Research, Universit\u00e0 degli Studi di Milano, 20133 Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Faedo","sequence":"additional","affiliation":[{"name":"Center for Stem Cell Research, Universit\u00e0 degli Studi di Milano, 20133 Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Menon","sequence":"additional","affiliation":[{"name":"Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Camnasio","sequence":"additional","affiliation":[{"name":"Center for Stem Cell Research, Universit\u00e0 degli Studi di Milano, 20133 Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Vuono","sequence":"additional","affiliation":[{"name":"Brain Repair Centre, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 0PY, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Spaiardi","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Talpo","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Toselli","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianvito","family":"Martino","sequence":"additional","affiliation":[{"name":"Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Barker","sequence":"additional","affiliation":[{"name":"Brain Repair Centre, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 0PY, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Dunnett","sequence":"additional","affiliation":[{"name":"School of Bioscience, Cardiff University, Cardiff CF10 3AX, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Biella","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Center for Stem Cell Research, Universit\u00e0 degli Studi di Milano, 20133 Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042622134625500_R1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/cercor\/bhm092","article-title":"Six3 controls the neural progenitor status in the murine CNS","volume":"18","author":"Appolloni","year":"2008","journal-title":"Cereb. 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