{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:20:59Z","timestamp":1792736459859,"version":"4.5.0"},"reference-count":53,"publisher":"The Company of Biologists","issue":"10","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":2675,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,15]]},"abstract":"<jats:p>Fascins, a family of actin-bundling proteins, are expressed in a spatially and temporally restricted manner during development and often in cancer. Fascin 1 has a clear role in cell migration in vitro, but its role in vivo in mammals is not well understood. Here, we investigate the role of fascin 1 in the melanocyte lineage and in melanoma cells. Fascin 1 knockout causes hypopigmentation in adult mice owing to migration and cell cycle progression defects in melanoblasts, the melanocyte precursor cell. Study of live embryo skin explants reveals that E14.5 fascin 1-null melanoblasts migrate slower, and generate fewer and thinner pseudopods. By contrast, fascin 1 expression drives faster migration and lamellipodia protrusion in melanocytes in vitro. In addition, fascin 1 depletion retards melanoblast proliferation in vivo and melanoma cell growth in vitro. These data indicate that fascin 1 not only promotes cell migration in mouse melanocytes but it also has a role in growth and cell cycle progression.<\/jats:p>","DOI":"10.1242\/dev.089789","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T12:59:22Z","timestamp":1367326762000},"page":"2203-2211","source":"Crossref","is-referenced-by-count":52,"title":["Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation"],"prefix":"10.1242","volume":"140","author":[{"given":"Yafeng","family":"Ma","sequence":"first","affiliation":[{"name":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[{"name":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Faller","sequence":"additional","affiliation":[{"name":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Libertini","sequence":"additional","affiliation":[{"name":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Fiorito","sequence":"additional","affiliation":[{"name":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen J.","family":"Sansom","sequence":"additional","affiliation":[{"name":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeko","family":"Yamashiro","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Machesky","sequence":"additional","affiliation":[{"name":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042622083806000_R1","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1158\/0008-5472.CAN-04-2970","article-title":"Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background","volume":"65","author":"Ackermann","year":"2005","journal-title":"Cancer Res."},{"key":"2021042622083806000_R2","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1091\/mbc.8.11.2345","article-title":"Characterization of cell-matrix adhesion requirements for the formation of fascin microspikes","volume":"8","author":"Adams","year":"1997","journal-title":"Mol. 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