{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:59:10Z","timestamp":1791331150216,"version":"4.3.1"},"reference-count":37,"publisher":"The Company of Biologists","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,15]]},"abstract":"<jats:p>Pancreatic multipotent progenitor cells (MPCs) produce acinar, endocrine and duct cells during organogenesis, but their existence and location in the mature organ remain contentious. We used inducible lineage-tracing from the MPC-instructive gene Ptf1a to define systematically in mice the switch of Ptf1a+ MPCs to unipotent proacinar competence during the secondary transition, their rapid decline during organogenesis, and absence from the mature organ. Between E11.5 and E15.5, we describe tip epithelium heterogeneity, suggesting that putative Ptf1a+Sox9+Hnf1\u03b2+ MPCs are intermingled with Ptf1aHISox9LO proacinar progenitors. In the adult, pancreatic duct ligation (PDL) caused facultative reactivation of multipotency factors (Sox9 and Hnf1\u03b2) in Ptf1a+ acini, which undergo rapid reprogramming to duct cells and longer-term reprogramming to endocrine cells, including insulin+ \u03b2-cells that are mature by the criteria of producing Pdx1HI, Nkx6.1+ and MafA+. These Ptf1a lineage-derived endocrine\/\u03b2-cells are likely formed via Ck19+\/Hnf1\u03b2+\/Sox9+ ductal and Ngn3+ endocrine progenitor intermediates. Acinar to endocrine\/\u03b2-cell transdifferentiation was enhanced by combining PDL with pharmacological elimination of pre-existing \u03b2-cells. Thus, we show that acinar cells, without exogenously introduced factors, can regain aspects of embryonic multipotentiality under injury, and convert into mature \u03b2-cells.<\/jats:p>","DOI":"10.1242\/dev.090159","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T07:02:17Z","timestamp":1358406137000},"page":"751-764","source":"Crossref","is-referenced-by-count":283,"title":["Spatiotemporal patterns of multipotentiality in <i>Ptf1a<\/i>-expressing cells during pancreas organogenesis and injury-induced facultative restoration"],"prefix":"10.1242","volume":"140","author":[{"given":"Fong Cheng","family":"Pan","sequence":"first","affiliation":[{"name":"Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Bankaitis","sequence":"additional","affiliation":[{"name":"Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Boyer","sequence":"additional","affiliation":[{"name":"Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Childrens Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 922, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Van de Casteele","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Vrije Universiteit Brussels, Laarbeeklaan 103 D2, Brussels, B1090 Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Magnuson","sequence":"additional","affiliation":[{"name":"Vanderbilt University Center for Stem Cell Biology, 9465 MRB IV, 2213 Garland Avenue, Nashville, TN 37232-0494, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Heimberg","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Vrije Universiteit Brussels, Laarbeeklaan 103 D2, Brussels, B1090 Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher V. 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