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This Review outlines these advances with a focus on ageing and rejuvenation of key endogenous stem and progenitor cell compartments in the CNS. Insights gleaned from studies of model organisms, chiefly rodents, will be considered in parallel with human studies.<\/jats:p>","DOI":"10.1242\/dev.092262","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:14:02Z","timestamp":1369786442000},"page":"2562-2575","source":"Crossref","is-referenced-by-count":44,"title":["Ageing stem and progenitor cells: implications for rejuvenation of the central nervous system"],"prefix":"10.1242","volume":"140","author":[{"given":"Peter","family":"van Wijngaarden","sequence":"first","affiliation":[{"name":"Wellcome Trust-MRC Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK"},{"name":"Centre for Eye Research Australia, University of Melbourne, Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street East, Melbourne, Victoria 3002, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin J. 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Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb","volume":"137","author":"Altman","year":"1969","journal-title":"J. Comp. Neurol."},{"key":"2021042607190649700_R6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/cne.903010304","article-title":"Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods","volume":"301","author":"Altman","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"2021042607190649700_R7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cne.901240303","article-title":"Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats","volume":"124","author":"Altman","year":"1965","journal-title":"J. Comp. Neurol."},{"key":"2021042607190649700_R8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1006\/exnr.2001.7691","article-title":"Isolation of multipotent neural precursors residing in the cortex of the adult human brain","volume":"170","author":"Arsenijevic","year":"2001","journal-title":"Exp. Neurol."},{"key":"2021042607190649700_R9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.18632\/aging.100446","article-title":"Age-related cognitive decline: can neural stem cells help us?","volume":"4","author":"Artegiani","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"2021042607190649700_R10","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"2021042607190649700_R11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1227\/01.NEU.0000311081.50648.4C","article-title":"Long-term expansion of adult human brain subventricular zone precursors","volume":"62","author":"Ayuso-Sacido","year":"2008","journal-title":"Neurosurgery"},{"key":"2021042607190649700_R12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1017\/S1740925X09990202","article-title":"Electrical signalling properties of oligodendrocyte precursor cells","volume":"5","author":"Bakiri","year":"2009","journal-title":"Neuron Glia Biol."},{"key":"2021042607190649700_R13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/archneur.60.3.393","article-title":"White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study","volume":"60","author":"Bartzokis","year":"2003","journal-title":"Arch. Neurol."},{"key":"2021042607190649700_R14","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.neurobiolaging.2008.08.015","article-title":"Lifespan trajectory of myelin integrity and maximum motor speed","volume":"31","author":"Bartzokis","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"2021042607190649700_R15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neurobiolaging.2008.03.002","article-title":"Early age-related changes in adult hippocampal neurogenesis in C57 mice","volume":"31","author":"Ben Abdallah","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"2021042607190649700_R16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.mcn.2009.04.007","article-title":"Circumventricular organs: a novel site of neural stem cells in the adult brain","volume":"41","author":"Bennett","year":"2009","journal-title":"Mol. Cell. 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USA"},{"key":"2021042607190649700_R38","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.neuroscience.2006.01.040","article-title":"The aging hippocampus: a multi-level analysis in the rat","volume":"139","author":"Driscoll","year":"2006","journal-title":"Neuroscience"},{"key":"2021042607190649700_R39","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/MOT.0b013e32834c2356","article-title":"Clinical translation of cell transplantation in the brain","volume":"16","author":"Dunnett","year":"2011","journal-title":"Curr. Opin. Organ Transplant."},{"key":"2021042607190649700_R40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2164-8-80","article-title":"Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program","volume":"8","author":"Edwards","year":"2007","journal-title":"BMC Genomics"},{"key":"2021042607190649700_R41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00441-011-1200-z","article-title":"Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice","volume":"345","author":"Ehninger","year":"2011","journal-title":"Cell Tissue Res."},{"key":"2021042607190649700_R42","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1126\/science.1222941","article-title":"Depression and hippocampal neurogenesis: a road to remission?","volume":"338","author":"Eisch","year":"2012","journal-title":"Science"},{"key":"2021042607190649700_R43","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.neurobiolaging.2010.01.007","article-title":"Increased neural progenitors in vascular dementia","volume":"32","author":"Ekonomou","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"2021042607190649700_R44","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1523\/JNEUROSCI.2751-04.2004","article-title":"Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination","volume":"24","author":"Enwere","year":"2004","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R45","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus","volume":"4","author":"Eriksson","year":"1998","journal-title":"Nat. Med."},{"key":"2021042607190649700_R46","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1111\/j.1460-9568.2003.03041.x","article-title":"VEGF is necessary for exercise-induced adult hippocampal neurogenesis","volume":"18","author":"Fabel","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"2021042607190649700_R47","doi-asserted-by":"crossref","first-page":"14157","DOI":"10.1073\/pnas.0806658105","article-title":"Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain","volume":"105","author":"Faulkner","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042607190649700_R48","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1523\/JNEUROSCI.17-19-07267.1997","article-title":"Conduction in segmentally demyelinated mammalian central axons","volume":"17","author":"Felts","year":"1997","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R49","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/cdd.2011.179","article-title":"FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression","volume":"19","author":"Ferber","year":"2012","journal-title":"Cell Death Differ."},{"key":"2021042607190649700_R50","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1199139","article-title":"Neuroscience. Change in the brain's white matter","volume":"330","author":"Fields","year":"2010","journal-title":"Science"},{"key":"2021042607190649700_R51","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature08197","article-title":"Recent progress in the biology and physiology of sirtuins","volume":"460","author":"Finkel","year":"2009","journal-title":"Nature"},{"key":"2021042607190649700_R52","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1073\/pnas.0809594106","article-title":"Association of FOXO3A variation with human longevity confirmed in German centenarians","volume":"106","author":"Flachsbart","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042607190649700_R53","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1474-9726.2008.00417.x","article-title":"Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans","volume":"7","author":"Fontana","year":"2008","journal-title":"Aging Cell"},{"key":"2021042607190649700_R54","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending healthy life span\u2014from yeast to humans","volume":"328","author":"Fontana","year":"2010","journal-title":"Science"},{"key":"2021042607190649700_R55","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nrneurol.2012.27","article-title":"Modifiable factors that alter the size of the hippocampus with ageing","volume":"8","author":"Fotuhi","year":"2012","journal-title":"Nat Rev Neurol."},{"key":"2021042607190649700_R56","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.bbr.2011.04.022","article-title":"Role of vascular endothelial growth factor in adult hippocampal neurogenesis: implications for the pathophysiology and treatment of depression","volume":"227","author":"Fournier","year":"2012","journal-title":"Behav. Brain Res."},{"key":"2021042607190649700_R57","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrn2480","article-title":"Remyelination in the CNS: from biology to therapy","volume":"9","author":"Franklin","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042607190649700_R58","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nrneurol.2012.200","article-title":"Neuroprotection and repair in multiple sclerosis","volume":"8","author":"Franklin","year":"2012","journal-title":"Nat Rev Neurol."},{"key":"2021042607190649700_R59","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature11007","article-title":"Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity","volume":"485","author":"F\u00fcnfschilling","year":"2012","journal-title":"Nature"},{"key":"2021042607190649700_R60","article-title":"Neuro-immune interactions of neural stem cell transplants: From animal disease models to human trials","author":"Giusto","year":"2013","journal-title":"Exp Neurol."},{"key":"2021042607190649700_R61","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature08619","article-title":"Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila","volume":"462","author":"Grandison","year":"2009","journal-title":"Nature"},{"key":"2021042607190649700_R62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1748-1716.2007.01780.x","article-title":"FOXO transcription factors in ageing and cancer","volume":"192","author":"Greer","year":"2008","journal-title":"Acta Physiol. (Oxf.)"},{"key":"2021042607190649700_R63","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/glia.22281","article-title":"Erk1\/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiation","volume":"60","author":"Guardiola-Diaz","year":"2012","journal-title":"Glia"},{"key":"2021042607190649700_R64","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1523\/JNEUROSCI.1360-10.2010","article-title":"Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex","volume":"30","author":"Guo","year":"2010","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neurobiolaging.2006.09.015","article-title":"Aging does not alter the number or phenotype of putative stem\/progenitor cells in the neurogenic region of the hippocampus","volume":"29","author":"Hattiangady","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"2021042607190649700_R66","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.expneurol.2005.05.014","article-title":"Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus","volume":"195","author":"Hattiangady","year":"2005","journal-title":"Exp. Neurol."},{"key":"2021042607190649700_R67","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1007\/s11064-007-9341-x","article-title":"What's behind the decline? The role of white matter in brain aging","volume":"32","author":"Hinman","year":"2007","journal-title":"Neurochem. Res."},{"key":"2021042607190649700_R68","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1153058","article-title":"Comment on \u201cmagnetic resonance spectroscopy identifies neural progenitor cells in the live human brain\u201d","volume":"321","author":"Hoch","year":"2008","journal-title":"Science"},{"key":"2021042607190649700_R69","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1523\/JNEUROSCI.20-06-02218.2000","article-title":"Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord","volume":"20","author":"Horner","year":"2000","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R70","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nn.2702","article-title":"Retinoid X receptor gamma signaling accelerates CNS remyelination","volume":"14","author":"Huang","year":"2011","journal-title":"Nat. Neurosci."},{"key":"2021042607190649700_R71","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.semcdb.2012.04.003","article-title":"Oxidative stress and adult neurogenesis\u2014effects of radiation and superoxide dismutase deficiency","volume":"23","author":"Huang","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"2021042607190649700_R72","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tips.2010.02.003","article-title":"Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases","volume":"31","author":"Imai","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"2021042607190649700_R73","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1153997","article-title":"Comment on \u201cMagnetic resonance spectroscopy identifies neural progenitor cells in the live human brain\u201d","volume":"321","author":"Jansen","year":"2008","journal-title":"Science"},{"key":"2021042607190649700_R74","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature09603","article-title":"Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice","volume":"469","author":"Jaskelioff","year":"2011","journal-title":"Nature"},{"key":"2021042607190649700_R75","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1101\/lm.1172609","article-title":"Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats","volume":"16","author":"Jessberger","year":"2009","journal-title":"Learn. Mem."},{"key":"2021042607190649700_R76","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1073\/pnas.2634794100","article-title":"Increased hippocampal neurogenesis in Alzheimer's disease","volume":"101","author":"Jin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042607190649700_R77","doi-asserted-by":"crossref","first-page":"18189","DOI":"10.1073\/pnas.0506375102","article-title":"FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease","volume":"102","author":"Jin","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042607190649700_R78","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/cne.22527","article-title":"Decline in adult neurogenesis during aging follows a topographic pattern in the mouse hippocampus","volume":"519","author":"Jinno","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"2021042607190649700_R79","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1006\/excr.1999.4678","article-title":"Neural stem cells in the adult human brain","volume":"253","author":"Johansson","year":"1999","journal-title":"Exp. Cell Res."},{"key":"2021042607190649700_R80","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature11861","article-title":"mTOR is a key modulator of ageing and age-related disease","volume":"493","author":"Johnson","year":"2013","journal-title":"Nature"},{"key":"2021042607190649700_R81","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jchemneu.2008.12.009","article-title":"The cellular composition and morphological organization of the rostral migratory stream in the adult human brain","volume":"37","author":"Kam","year":"2009","journal-title":"J. Chem. Neuroanat."},{"key":"2021042607190649700_R82","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.neuron.2010.09.009","article-title":"NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration","volume":"68","author":"Kang","year":"2010","journal-title":"Neuron"},{"key":"2021042607190649700_R83","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.887941","article-title":"Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs","volume":"197","author":"Kaplan","year":"1977","journal-title":"Science"},{"key":"2021042607190649700_R84","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nn2060","article-title":"Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter","volume":"11","author":"K\u00e1rad\u00f3ttir","year":"2008","journal-title":"Nat. Neurosci."},{"key":"2021042607190649700_R85","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrn3319","article-title":"New neurons for \u2018survival of the fittest\u2019","volume":"13","author":"Kempermann","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042607190649700_R86","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/386493a0","article-title":"More hippocampal neurons in adult mice living in an enriched environment","volume":"386","author":"Kempermann","year":"1997","journal-title":"Nature"},{"key":"2021042607190649700_R87","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1523\/JNEUROSCI.18-09-03206.1998","article-title":"Experience-induced neurogenesis in the senescent dentate gyrus","volume":"18","author":"Kempermann","year":"1998","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R88","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ana.10262","article-title":"Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment","volume":"52","author":"Kempermann","year":"2002","journal-title":"Ann. Neurol."},{"key":"2021042607190649700_R89","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.tins.2004.05.013","article-title":"Milestones of neuronal development in the adult hippocampus","volume":"27","author":"Kempermann","year":"2004","journal-title":"Trends Neurosci."},{"key":"2021042607190649700_R90","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature08980","article-title":"The genetics of ageing","volume":"464","author":"Kenyon","year":"2010","journal-title":"Nature"},{"key":"2021042607190649700_R91","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.bbr.2011.07.012","article-title":"Time-dependent involvement of adult-born dentate granule cells in behavior","volume":"227","author":"Kim","year":"2012","journal-title":"Behav. Brain Res."},{"key":"2021042607190649700_R92","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/cercor\/4.6.576","article-title":"In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain","volume":"4","author":"Kirschenbaum","year":"1994","journal-title":"Cereb. Cortex"},{"key":"2021042607190649700_R93","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.cell.2009.10.020","article-title":"Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory","volume":"139","author":"Kitamura","year":"2009","journal-title":"Cell"},{"key":"2021042607190649700_R94","doi-asserted-by":"crossref","first-page":"e8809","DOI":"10.1371\/journal.pone.0008809","article-title":"Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years","volume":"5","author":"Knoth","year":"2010","journal-title":"PLoS ONE"},{"key":"2021042607190649700_R95","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.bbi.2011.10.006","article-title":"Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice","volume":"26","author":"Kohman","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"2021042607190649700_R96","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/nn.3163","article-title":"Cross-talk between neural stem cells and immune cells: the key to better brain repair?","volume":"15","author":"Kokaia","year":"2012","journal-title":"Nat. Neurosci."},{"key":"2021042607190649700_R97","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1126\/science.289.5485.1754","article-title":"Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells","volume":"289","author":"Kondo","year":"2000","journal-title":"Science"},{"key":"2021042607190649700_R98","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1523\/JNEUROSCI.2615-05.2006","article-title":"Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation","volume":"26","author":"Kotter","year":"2006","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R99","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf expression is a biomarker of aging","volume":"114","author":"Krishnamurthy","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2021042607190649700_R100","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.neurobiolaging.2005.09.016","article-title":"Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus","volume":"27","author":"Kronenberg","year":"2006","journal-title":"Neurobiol. 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Neurosci."},{"key":"2021042607190649700_R103","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1523\/JNEUROSCI.17-15-05820.1997","article-title":"Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain","volume":"17","author":"Kuhn","year":"1997","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R104","doi-asserted-by":"crossref","first-page":"e409","DOI":"10.1371\/journal.pbio.0040409","article-title":"Functional convergence of neurons generated in the developing and adult hippocampus","volume":"4","author":"Laplagne","year":"2006","journal-title":"PLoS Biol."},{"key":"2021042607190649700_R105","doi-asserted-by":"crossref","first-page":"e26812","DOI":"10.1371\/journal.pone.0026812","article-title":"Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice","volume":"6","author":"Latimer","year":"2011","journal-title":"PLoS ONE"},{"key":"2021042607190649700_R106","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tins.2010.09.006","article-title":"Is adult neurogenesis essential for olfaction?","volume":"34","author":"Lazarini","year":"2011","journal-title":"Trends Neurosci."},{"key":"2021042607190649700_R107","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.stem.2010.11.028","article-title":"Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K\/Akt-dependant manner","volume":"8","author":"Le Belle","year":"2011","journal-title":"Cell Stem Cell"},{"key":"2021042607190649700_R108","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1385\/JMN:15:2:99","article-title":"Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats","volume":"15","author":"Lee","year":"2000","journal-title":"J. Mol. Neurosci."},{"key":"2021042607190649700_R109","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1046\/j.1471-4159.2002.01085.x","article-title":"Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice","volume":"82","author":"Lee","year":"2002","journal-title":"J. Neurochem."},{"key":"2021042607190649700_R110","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.0022-3042.2001.00747.x","article-title":"Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice","volume":"80","author":"Lee","year":"2002","journal-title":"J. Neurochem."},{"key":"2021042607190649700_R111","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/jnr.20831","article-title":"Interferon-gamma is up-regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity","volume":"83","author":"Lee","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"2021042607190649700_R112","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature11314","article-title":"Oligodendroglia metabolically support axons and contribute to neurodegeneration","volume":"487","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"2021042607190649700_R113","doi-asserted-by":"crossref","first-page":"17169","DOI":"10.1073\/pnas.0708228104","article-title":"Diminished adult neurogenesis in the marmoset brain precedes old age","volume":"104","author":"Leuner","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042607190649700_R114","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0896-6273(93)90311-E","article-title":"Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain","volume":"10","author":"Levison","year":"1993","journal-title":"Neuron"},{"key":"2021042607190649700_R115","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1371\/journal.pbio.0050035","article-title":"Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function","volume":"5","author":"Li","year":"2007","journal-title":"PLoS Biol."},{"key":"2021042607190649700_R116","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0306-4522(01)00378-5","article-title":"Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis","volume":"107","author":"Lichtenwalner","year":"2001","journal-title":"Neuroscience"},{"key":"2021042607190649700_R117","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/nn.3263","article-title":"Impaired adult myelination in the prefrontal cortex of socially isolated mice","volume":"15","author":"Liu","year":"2012","journal-title":"Nat. Neurosci."},{"key":"2021042607190649700_R118","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.8178174","article-title":"Long-distance neuronal migration in the adult mammalian brain","volume":"264","author":"Lois","year":"1994","journal-title":"Science"},{"key":"2021042607190649700_R119","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1080\/13803395.2011.595397","article-title":"Age-related slowing in cognitive processing speed is associated with myelin integrity in a very healthy elderly sample","volume":"33","author":"Lu","year":"2011","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"2021042607190649700_R120","first-page":"382","article-title":"Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors","volume":"43","author":"Ludwin","year":"1980","journal-title":"Lab. Invest."},{"key":"2021042607190649700_R121","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.stem.2010.03.017","article-title":"Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging","volume":"6","author":"Lugert","year":"2010","journal-title":"Cell Stem Cell"},{"key":"2021042607190649700_R122","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0896-6273(93)90281-U","article-title":"Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone","volume":"11","author":"Luskin","year":"1993","journal-title":"Neuron"},{"key":"2021042607190649700_R123","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1126\/science.1220845","article-title":"A critical period for social experience-dependent oligodendrocyte maturation and myelination","volume":"337","author":"Makinodan","year":"2012","journal-title":"Science"},{"key":"2021042607190649700_R124","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1126\/science.1147851","article-title":"Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain","volume":"318","author":"Manganas","year":"2007","journal-title":"Science"},{"key":"2021042607190649700_R125","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2217\/fnl.10.33","article-title":"Insights into neurogenesis and aging: potential therapy for degenerative disease?","volume":"5","author":"Marr","year":"2010","journal-title":"Future Neurol."},{"key":"2021042607190649700_R126","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrn1908","article-title":"The therapeutic potential of neural stem cells","volume":"7","author":"Martino","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042607190649700_R127","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0002-9440(10)63726-1","article-title":"Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions","volume":"164","author":"Mason","year":"2004","journal-title":"Am. J. Pathol."},{"key":"2021042607190649700_R128","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1113\/jphysiol.2011.217919","article-title":"Brain glycogen supercompensation following exhaustive exercise","volume":"590","author":"Matsui","year":"2012","journal-title":"J. Physiol."},{"key":"2021042607190649700_R129","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neulet.2005.05.022","article-title":"Dynamics of neurogenesis in the dentate gyrus of adult rats","volume":"385","author":"McDonald","year":"2005","journal-title":"Neurosci. Lett."},{"key":"2021042607190649700_R130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/bmj.317.7151.111","article-title":"Demographic and epidemiological determinants of healthcare costs in Netherlands: cost of illness study","volume":"317","author":"Meerding","year":"1998","journal-title":"BMJ"},{"key":"2021042607190649700_R131","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1523\/JNEUROSCI.1299-06.2006","article-title":"Origin of oligodendrocytes in the subventricular zone of the adult brain","volume":"26","author":"Menn","year":"2006","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R132","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/cne.10616","article-title":"Hippocampal cell genesis does not correlate with spatial learning ability in aged rats","volume":"459","author":"Merrill","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"2021042607190649700_R133","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"2021042607190649700_R134","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1523\/JNEUROSCI.4065-07.2008","article-title":"Retinoid hyposignaling contributes to aging-related decline in hippocampal function in short-term\/working memory organization and long-term declarative memory encoding in mice","volume":"28","author":"Mingaud","year":"2008","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2007.02.001","article-title":"Foxo3a is essential for maintenance of the hematopoietic stem cell pool","volume":"1","author":"Miyamoto","year":"2007","journal-title":"Cell Stem Cell"},{"key":"2021042607190649700_R136","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature05091","article-title":"Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing","volume":"443","author":"Molofsky","year":"2006","journal-title":"Nature"},{"key":"2021042607190649700_R137","doi-asserted-by":"crossref","first-page":"e5320","DOI":"10.1371\/journal.pone.0005320","article-title":"Reliable activation of immature neurons in the adult hippocampus","volume":"4","author":"Mongiat","year":"2009","journal-title":"PLoS ONE"},{"key":"2021042607190649700_R138","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neurobiolaging.2005.02.014","article-title":"Lifelong corticosterone level determines age-related decline in neurogenesis and memory","volume":"27","author":"Montaron","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"2021042607190649700_R139","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainres.2011.12.049","article-title":"Stress, neurotransmitters, corticosterone and body-brain integration","volume":"1476","author":"Mora","year":"2012","journal-title":"Brain Res."},{"key":"2021042607190649700_R140","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1113\/jphysiol.2008.154807","article-title":"Newborn granule cells in the ageing dentate gyrus","volume":"586","author":"Morgenstern","year":"2008","journal-title":"J. Physiol."},{"key":"2021042607190649700_R141","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1046\/j.1460-9568.1999.00873.x","article-title":"Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination","volume":"11","author":"Nait-Oumesmar","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"2021042607190649700_R142","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cell.2012.01.046","article-title":"Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion","volume":"149","author":"Nakashiba","year":"2012","journal-title":"Cell"},{"key":"2021042607190649700_R143","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.neuro.30.051606.094309","article-title":"Axon-glial signaling and the glial support of axon function","volume":"31","author":"Nave","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"2021042607190649700_R144","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nm837","article-title":"Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain","volume":"9","author":"Nunes","year":"2003","journal-title":"Nat. Med."},{"key":"2021042607190649700_R145","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/cne.21268","article-title":"Decreased neurogenesis in aged rats results from loss of granule cell precursors without lengthening of the cell cycle","volume":"501","author":"Olariu","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"2021042607190649700_R146","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cell.2006.12.029","article-title":"FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis","volume":"128","author":"Paik","year":"2007","journal-title":"Cell"},{"key":"2021042607190649700_R147","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.stem.2009.09.013","article-title":"FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis","volume":"5","author":"Paik","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2021042607190649700_R148","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/(SICI)1096-9861(19970728)384:2<312::AID-CNE10>3.0.CO;2-K","article-title":"Neocortical neuron number in humans: effect of sex and age","volume":"384","author":"Pakkenberg","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"2021042607190649700_R149","doi-asserted-by":"crossref","first-page":"15012","DOI":"10.1523\/JNEUROSCI.2248-12.2012","article-title":"Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain","volume":"32","author":"Paliouras","year":"2012","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R150","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1523\/JNEUROSCI.19-19-08487.1999","article-title":"Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS","volume":"19","author":"Palmer","year":"1999","journal-title":"J. Neurosci."},{"key":"2021042607190649700_R151","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/ana.10393","article-title":"Rat forebrain neurogenesis and striatal neuron replacement after focal stroke","volume":"52","author":"Parent","year":"2002","journal-title":"Ann. Neurol."},{"key":"2021042607190649700_R152","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1749-6632.2011.06089.x","article-title":"Neurogenic contributions made by dietary regulation to hippocampal neurogenesis","volume":"1229","author":"Park","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2021042607190649700_R153","doi-asserted-by":"crossref","first-page":"42588","DOI":"10.1074\/jbc.M112.406413","article-title":"Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis","volume":"287","author":"Park","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2021042607190649700_R154","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainres.2008.11.086","article-title":"Intra-hippocampal administration of the VEGF receptor blocker PTK787\/ZK222584 impairs long-term memory","volume":"1256","author":"Pati","year":"2009","journal-title":"Brain Res."},{"key":"2021042607190649700_R155","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.neurobiolaging.2007.04.013","article-title":"Neocortical glial cell numbers in human brains","volume":"29","author":"Pelvig","year":"2008","journal-title":"Neurobiol. 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(Wien)"},{"key":"2021042607190649700_R169","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.neuron.2011.05.013","article-title":"NG2-glia as multipotent neural stem cells: fact or fantasy?","volume":"70","author":"Richardson","year":"2011","journal-title":"Neuron"},{"key":"2021042607190649700_R170","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nn.2220","article-title":"PDGFRA\/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice","volume":"11","author":"Rivers","year":"2008","journal-title":"Nat. Neurosci."},{"key":"2021042607190649700_R171","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrn2978","article-title":"The stem cell potential of glia: lessons from reactive gliosis","volume":"12","author":"Robel","year":"2011","journal-title":"Nat. Rev. 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Neurosci."},{"key":"2021042607190649700_R189","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/glia.21156","article-title":"Progenitors in the adult cerebral cortex: cell cycle properties and regulation by physiological stimuli and injury","volume":"59","author":"Simon","year":"2011","journal-title":"Glia"},{"key":"2021042607190649700_R190","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrn3085","article-title":"A pathophysiological framework of hippocampal dysfunction in ageing and disease","volume":"12","author":"Small","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042607190649700_R191","doi-asserted-by":"crossref","first-page":"10032","DOI":"10.1073\/pnas.170209797","article-title":"Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell","volume":"97","author":"Smith","year":"2000","journal-title":"Proc. Natl. Acad. Sci. 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Res."},{"key":"2021042607190649700_R195","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neuroscience.2004.04.061","article-title":"Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington's disease","volume":"127","author":"Tattersfield","year":"2004","journal-title":"Neuroscience"},{"key":"2021042607190649700_R196","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nn.2156","article-title":"Neurons born in the adult dentate gyrus form functional synapses with target cells","volume":"11","author":"Toni","year":"2008","journal-title":"Nat. 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