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A loss-of-function mutant in Kif20b, magoo, was found in a forward genetic screen. magoo has a small cerebral cortex, with reduced production of progenitors and neurons, but preserved layering. In contrast to other microcephalic mouse mutants, mitosis and cleavage furrows of cortical stem cells appear normal in magoo. However, apical midbodies show changes in number, shape and positioning relative to the apical membrane. Interestingly, the disruption of abscission does not appear to result in binucleate cells, but in apoptosis. Thus, Kif20b is required for proper midbody organization and abscission in polarized cortical stem cells and has a crucial role in the regulation of cerebral cortex growth.<\/jats:p>","DOI":"10.1242\/dev.093286","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T23:02:36Z","timestamp":1383174156000},"page":"4672-4682","source":"Crossref","is-referenced-by-count":65,"title":["The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size"],"prefix":"10.1242","volume":"140","author":[{"given":"Kerstin M.","family":"Janisch","sequence":"first","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vita M.","family":"Vock","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayushma","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Grimsley-Myers","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bareza A.","family":"Rasoul","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Neale","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Cupp","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Kinchen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Karel F.","family":"Liem","sequence":"additional","affiliation":[{"name":"Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelle D.","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042607240296700_R1","doi-asserted-by":"crossref","first-page":"27844","DOI":"10.1074\/jbc.M304522200","article-title":"M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis","volume":"278","author":"Abaza","year":"2003","journal-title":"J. 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