{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:35:08Z","timestamp":1791570908288,"version":"4.3.4"},"reference-count":75,"publisher":"The Company of Biologists","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:p>Tbx2 and Tbx3 are two highly related members of the T-box transcription factor gene family that regulate patterning and differentiation of a number of tissue rudiments in the mouse. Both genes are partially co-expressed in the ventral diencephalon and the infundibulum; however, a functional requirement in murine pituitary development has not been reported. Here, we show by genetic lineage tracing that Tbx2+ cells constitute the precursor population of the neurohypophysis. However, Tbx2 is dispensable for neurohypophysis development as revealed by normal formation of this organ in Tbx2-deficient mice. By contrast, loss of Tbx3 from the ventral diencephalon results in a failure to establish the Tbx2+ domain in this region, and a lack of evagination of the infundibulum and formation of the neurohypophysis. Rathke's pouch is severely hypoplastic, exhibits defects in dorsoventral patterning, and degenerates after E12.5. In Tbx3-deficient embryos, the ventral diencephalon is hyperproliferative and displays an abnormal cellular architecture, probably resulting from a failure to repress transcription of Shh. We further show that Tbx3 and Tbx2 repress Shh by sequestering the SRY box-containing transcription factor Sox2 away from a Shh forebrain enhancer (SBE2), thus preventing its activation. These data suggest that Tbx3 is required in the ventral diencephalon to establish a Shh\u2212 domain to allow formation of the infundibulum.<\/jats:p>","DOI":"10.1242\/dev.094524","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T11:23:03Z","timestamp":1368530583000},"page":"2299-2309","source":"Crossref","is-referenced-by-count":73,"title":["Inhibition of Sox2-dependent activation of <i>Shh<\/i> in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis"],"prefix":"10.1242","volume":"140","author":[{"given":"Mark-Oliver","family":"Trowe","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Basic Medical College, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Carina","family":"Weiss","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Christoffels","sequence":"additional","affiliation":[{"name":"Heart Failure Research Center, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine at the University of Pennsylvania, Department of Genetics, Philadelphia, PA 19103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kispert","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606454769600_R1","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1161\/CIRCRESAHA.108.192450","article-title":"The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle","volume":"104","author":"Aanhaanen","year":"2009","journal-title":"Circ. 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