{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:22:49Z","timestamp":1792156969039,"version":"4.4.0"},"reference-count":39,"publisher":"The Company of Biologists","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,15]]},"abstract":"<jats:p>The organ of Corti consists of sensory hair cells (HCs) interdigitated with nonsensory supporting cells (SCs) to form a checkerboard-like cellular pattern. HCs are equipped with hair bundles on their apical surfaces. We previously reported that cell-adhesive nectins regulate the checkerboard-like cellular patterning of HCs and SCs in the mouse auditory epithelium. Nectin-1 and -3 are differentially expressed in normal HCs and SCs, respectively, and in Nectin-3-deficient mice a number of HCs are aberrantly attached to each other. We show here that these aberrantly attached HCs in Nectin-3-deficient mice, but not unattached ones, show disturbances of the orientation and morphology of the hair bundles and the positioning of the kinocilium, with additional abnormal localisation of cadherin-catenin complexes and the apical-basal polarity proteins Pals1 and Par-3. These results indicate that, owing to the loss of Nectin-3, hair cells contact each other inappropriately and form abnormal junctions, ultimately resulting in abnormal hair bundle orientation and morphology.<\/jats:p>","DOI":"10.1242\/dev.094995","type":"journal-article","created":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T12:23:04Z","timestamp":1388492584000},"page":"399-409","source":"Crossref","is-referenced-by-count":35,"title":["Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities"],"prefix":"10.1242","volume":"141","author":[{"given":"Terunobu","family":"Fukuda","sequence":"first","affiliation":[{"name":"Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."},{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanoko","family":"Kominami","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Tsu 514-8507, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideru","family":"Togashi","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Hirata","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Mizoguchi","sequence":"additional","affiliation":[{"name":"Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Tsu 514-8507, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Rikitake","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."},{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."},{"name":"Division of Signal Transduction, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Takai","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."},{"name":"Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0047, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042607484532700_R1","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1128\/MCB.01505-08","article-title":"Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins","volume":"29","author":"Adachi","year":"2009","journal-title":"Mol. 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