{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:43:51Z","timestamp":1760647431857},"reference-count":39,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[1987,8,1]],"date-time":"1987-08-01T00:00:00Z","timestamp":554774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The present study was directed towards the characterization of cell-specific histogenetic markers for the various epithelial elements of the adult and the developing guinea pig submandibular salivary gland. We have employed immunofluorescent labelling using three cytokeratin monoclonal antibodies, for which the polypeptide specificities towards guinea pig cyto-keratins were determined. All the epithelial elements of the adult gland were positively labelled with two monoclonal antibodies, namely KG 8.13 (\u2018broad spectrum\u2019 anti-cytokeratin) and antibody KsB.18 (reactive with a simple cytokeratin-specific polypeptide of 49\u00d7 103Mr). Antibody KS8.58 (reactive with a guinea pig cytokeratin polypeptide of 50\u00d7103Mr) labelled the basal cells of the large ducts, as well as the myoepithelium. During development of the gland, the submandibular anlage and its primary and secondary branches with their terminal buds, were uniformly labelled with the three antibodies; however, the cytokeratin polypeptides reactive with antibody KS8.58, which were apparently expressed in all cells of the developing ducts, gradually disappear from most of the ductal cells, starting at about 6 weeks of gestation, and remain only in the basal or reserve cells of the large ducts and the myoepithelium. These observations support the notion that the basal cells retain at least some of the properties of the embryonic glandular epithelium and could be considered as pluripotent reserve cells which may function as progenitors for other epithelial elements in the salivary glands epithelia.<\/jats:p>","DOI":"10.1242\/dev.100.4.699","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:35:19Z","timestamp":1619397319000},"page":"699-711","source":"Crossref","is-referenced-by-count":7,"title":["Cytokeratin polypeptide expression during the histogenesis of guinea pig submandibular salivary gland"],"prefix":"10.1242","volume":"100","author":[{"given":"Gabriel","family":"Marshak","sequence":"first","affiliation":[{"name":"University and Hadassah Medical School, Jerusalem 1 Department of Otolaryngology, Kaplan Hospital, Rehovot, Israel, affiliated with the Hebrew"},{"name":"University and Hadassah Medical School, Jerusalem 1 Department of Otolaryngology, Kaplan Hospital, Rehovot, Israel, affiliated with the Hebrew"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orith","family":"Leitner","sequence":"additional","affiliation":[{"name":"2 Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Geiger","sequence":"additional","affiliation":[{"name":"2 Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1987,8,1]]},"reference":[{"key":"2023040617132026600_","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/BF00711866","article-title":"Intermediate filaments: A family of homologous structure","volume":"2","author":"Anderton","year":"1981","journal-title":"J. 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