{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:35:21Z","timestamp":1767857721720,"version":"3.49.0"},"reference-count":45,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[1987,10,1]],"date-time":"1987-10-01T00:00:00Z","timestamp":560044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>When spontaneously ovulating LT\/Sv female mice are mated with fertile males, between one third and one half of the zygotes analysed at the first cleavage mitosis are found to be triploid. This is due to the fact that LT\/Sv females ovulate both primary and secondary oocytes, all of which are capable of being fertilized. Fertilization of the former group results in the production of digynic triploid conceptuses, while their diploid littermates result from the fertilization of normal secondary oocytes. The present study was therefore carried out in order to investigate the \u2018spontaneous\u2019 level of triploidy in these mice, and to provide insight into the developmental fate of the LT\/Sv triploid embryos, as previous studies had indicated that in this species triploids invariably fail to develop beyond the early postimplantation period. This study revealed that when autopsies were carried out on the 7th and 8th days of gestation, it was generally difficult to distinguish between the kary-ologically normal diploids and the digynic triploid conceptuses when only morphological criteria were used. However, by the 10th day of gestation, the triploid conceptuses could usually be readily distinguished from their diploid littermates by their smaller size and (occasionally) by their disorganized or abnormal morphological appearance.<\/jats:p>","DOI":"10.1242\/dev.101.2.383","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:36:22Z","timestamp":1619397382000},"page":"383-391","source":"Crossref","is-referenced-by-count":23,"title":["The postimplantation development of spontaneous digynic triploid embryos in LT\/Sv strain mice"],"prefix":"10.1242","volume":"101","author":[{"given":"M. H.","family":"Kaufman","sequence":"first","affiliation":[{"name":"University Medical School Department of Anatomy , , Teviot Place, Edinburgh, EH8 9AG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Speirs","sequence":"additional","affiliation":[{"name":"University Medical School Department of Anatomy , , Teviot Place, Edinburgh, EH8 9AG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1987,10,1]]},"reference":[{"key":"2023040617144555100_","first-page":"229","article-title":"Spontaneous polyploidy in laboratory mice, embryological and cytogenetic analysis","volume":"7","author":"Baranov","year":"1976","journal-title":"Ontogenez"},{"key":"2023040617144555100_","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0045-6039(84)90074-5","article-title":"Control of meiosis by somatic cells in mice, inheritance of the meiosis I error \u2018diploidy\u2019 and nondisjunction in sensitive NMRI\/Han oocytes ovulated from chimaeras","volume":"15","author":"Bartels","year":"1984","journal-title":"Cell Differ"},{"key":"2023040617144555100_","volume-title":"Parthenogenesis and Polyploidy in Mammalian Development","author":"Beatty","year":"1957"},{"key":"2023040617144555100_","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1469-1809.1978.tb01897.x","article-title":"The origin of human triploidy, integration of qualitative and quantitative evidence","volume":"41","author":"Beatty","year":"1978","journal-title":"Ann. 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