{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:32:26Z","timestamp":1790400746582,"version":"4.1.0"},"reference-count":25,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[1987,12,1]],"date-time":"1987-12-01T00:00:00Z","timestamp":565315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Female mice showing albino mosaicism due to an X-autosome translocation [Is(In7;X)Ct] have been studied in order to investigate the relationship between the distribution of melanin and the formation, early in development, of the abnormally small uncrossed retinofugal pathway characteristically found in all albino mammals. Earlier evidence indicates that cells normally bearing melanin play a role in producing the abnormality. In the mosaic mice, the albino gene is expressed in only about half of the cells due to random X-inactivation apd the patches of normal and albino cells are extremely small relative to total retinal size (&amp;lt;l\/50). We argued that if all the cells that would normally bear melanin play a role in producing the albino abnormality then the mosaic mice would have a pathway abnormality, about half the size of that in the albino mice. If, however, only a small patch of these cells plays a role, as has been proposed in earlier studies, then one would expect the size of the uncrossed pathway to be highly variable in the mosaic mice.<\/jats:p>\n               <jats:p>The size of the uncrossed pathway was assessed by placing horseradish peroxidase in the region of the optic tract and lateral geniculate nucleus unilaterally and then counting the number of retrogradely labelled retinal ganglion cells on the same side. The mosaic mice showed a highly variable uncrossed pathway. In some of the mosaic mice, it was the same size as in the albinos and, in others, it was the same size as in normally pigmented mice. Surprisingly, in a small number of mosaic mice, the uncrossed pathway was larger than normal. Whether this relatively rare occurrence of a supernormal uncrossed pathway is due to the higher gene dosage or to the translocation itself remains an open question.<\/jats:p>","DOI":"10.1242\/dev.101.4.857","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T18:13:29Z","timestamp":1619201609000},"page":"857-867","source":"Crossref","is-referenced-by-count":20,"title":["Abnormally high variability in the uncrossed retinofugal pathway of mice with albino mosaicism"],"prefix":"10.1242","volume":"101","author":[{"given":"R. W.","family":"Jeffery","sequence":"first","affiliation":[{"name":"1 Department of Human Anatomy, South Parks Road, Oxford 0X1 3QX. UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Jeffery","sequence":"additional","affiliation":[{"name":"1 Department of Human Anatomy, South Parks Road, Oxford 0X1 3QX. UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M.","family":"Cattanach","sequence":"additional","affiliation":[{"name":"2 MRC Radiobiology Unit, Chilton, Didcot 0X11 0RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1987,12,1]]},"reference":[{"key":"2023040617120941600_","first-page":"165","article-title":"A chemically-induced varigated-type position effect in the mouse","volume":"92","author":"Cattanach","year":"1961","journal-title":"X. Vererbungslehre"},{"key":"2023040617120941600_","first-page":"907","article-title":"Retinal projections in tyrosinase-negative albino cats","volume":"2","author":"Creel","year":"1982","journal-title":"J. Neurosa"},{"key":"2023040617120941600_","first-page":"430","article-title":"Asymmetric visual evoked potentials in human albinos: evidence for visual system anomalies","volume":"13","author":"Creel","year":"1974","journal-title":"Invest. 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