{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:39:13Z","timestamp":1754397553081},"reference-count":46,"publisher":"The Company of Biologists","issue":"Supplement","license":[{"start":{"date-parts":[[1987,3,1]],"date-time":"1987-03-01T00:00:00Z","timestamp":541555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Mice provide material for studies of Y-chromosomal and autosomal sequences involved in sex determination. Eicher and coworkers have identified four subregions in the mouse Y chromosome, one of which corresponds to the Sxr fragment. This fragment demonstrates that only a small portion of the Y is necessary for male sex determination. The mouse Y chromosome also shows variants: the BALB\/cWt Y chromosome, which causes nondisjunction of the Y in some germ cells leading to XO and XYY cells and resulting in many infertile true hermaphrodites; the YDom, a wild-type chromosome which can result in sex reversal on a C57BL\/6J background; and Y-chromosomal variants detected with Y-derived genomic DNA clones among inbred strains. Two different autosomal loci affecting sex differentiation have been identified in the mouse by Eicher and coworkers. The first of these has not been mapped to a particular chromosome and has been designated Tda-1 (Testis-determining autosomal-1). This is the locus in C57BL\/6J mice at which animals must be homozygous in order to develop as true hermaphrodites or sex-reversed animals in the presence of YDom. The other locus has been identified on proximal chromosome 17. This locus also caused hermaphrodites on the C57BL\/6J background and it is most easily interpreted as a locus deleted in 7hp. It is located in a region on chromosome 17 containing other genes or DNA sequences that may be related to sex determination. These include both the Hye (histocompatibility Y expression) locus that affects the amount of male-specific antigen detected by serological and cell-mediated assays and a concentration of Bkm sequences. Despite the Y and chromosomal 17 localizations of Bkm sequences, there is no evidence that transcripts from these are involved in sex determination: RNA hybridizing to sense and anti-sense Bkm clones can be detected in day-14 fetal gonads of both sexes.<\/jats:p>","DOI":"10.1242\/dev.101.supplement.25","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T18:22:19Z","timestamp":1619202139000},"page":"25-32","source":"Crossref","is-referenced-by-count":4,"title":["Sex determination in mice: Y and chromosome 17 interactions"],"prefix":"10.1242","volume":"101","author":[{"given":"Robert P.","family":"Erickson","sequence":"first","affiliation":[{"name":"University of Michigan Medical School Departments of Human Genetics and Pediatrics , , Ann Arbor, MI 48109-0618, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Durbin","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School Departments of Human Genetics and Pediatrics , , Ann Arbor, MI 48109-0618, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Tres","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine Department of Pediatrics , , Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1987,3,1]]},"reference":[{"key":"2023121420053371400_DEVELOP_101_S_25C1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-4684-3390-6_15","article-title":"Spontaneous sex mosaicism in BALB\/cWt","volume-title":"Symposium on Genetic Mosaics and Chimeras in Mammals","author":"Beamer","year":"1978"},{"key":"2023121420053371400_DEVELOP_101_S_25C2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/315070a0","article-title":"Most classical Mus musculus domesticus laboratory mouse strains carry a Mus musculus musculus Y chromosome","volume":"315","author":"Bishop","year":"1985","journal-title":"Nature. 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