{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:43:46Z","timestamp":1791236626496,"version":"4.1.0"},"reference-count":81,"publisher":"The Company of Biologists","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,15]]},"abstract":"<jats:p>We previously identified a Drosophila maternal effect-lethal mutant named \u2018no poles\u2019 (nopo). Embryos from nopo females undergo mitotic arrest with barrel-shaped, acentrosomal spindles during the rapid cycles of syncytial embryogenesis because of activation of a Chk2-mediated DNA checkpoint. NOPO is the Drosophila homolog of human TNF receptor associated factor (TRAF)-interacting protein (TRIP), which has been implicated in TNF signaling. NOPO and TRIP contain RING domains closely resembling those of known E3 ubiquitin ligases. We herein sought to elucidate the mechanism by which TRIP\/NOPO promotes genomic stability by performing a yeast two-hybrid screen to identify potential substrates\/interactors. We identified members of the Y-family of DNA polymerases that facilitate replicative bypass of damaged DNA (translesion synthesis) as TRIP interactors. We show that TRIP and NOPO co-immunoprecipitate with human and Drosophila Pol\u03b7, respectively, from cultured cells. We generated a null mutation in Drosophila Pol\u03b7 (dPol\u03b7) and found that dPol\u03b7-derived embryos have increased sensitivity to ultraviolet irradiation and exhibit nopo-like mitotic spindle defects. dPol\u03b7 and nopo interact genetically in that overexpression of dPol\u03b7 in hypomorphic nopo-derived embryos suppresses nopo phenotypes. We observed enhanced ubiquitylation of Pol\u03b7 by TRIP and NOPO E3 ligases in human cells and Drosophila embryos, respectively, and show that TRIP promotes hPol\u03b7 localization to nuclear foci in human cells. We present a model in which TRIP\/NOPO ubiquitylates Pol\u03b7 to positively regulate its activity in translesion synthesis.<\/jats:p>","DOI":"10.1242\/dev.101196","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T04:37:20Z","timestamp":1392871040000},"page":"1332-1341","source":"Crossref","is-referenced-by-count":29,"title":["TRIP\/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase \u03b7"],"prefix":"10.1242","volume":"141","author":[{"given":"Heather A.","family":"Wallace","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U-4225 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA."},{"name":"Department of Genetics and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Merkle","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U-4225 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U-4225 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taloa G.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U-4225 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U-4225 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Genetics and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U-4225 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042607591370400_R1","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/S0960-9822(02)01165-X","article-title":"Activation of a meiotic checkpoint during Drosophila oogenesis regulates the translation of Gurken through Chk2\/Mnk","volume":"12","author":"Abdu","year":"2002","journal-title":"Curr. 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Cell Biol."},{"key":"2021042607591370400_R5","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.dnarep.2010.09.011","article-title":"The ubiquitous role of ubiquitin in the DNA damage response","volume":"9","author":"Al-Hakim","year":"2010","journal-title":"DNA Repair (Amst.)"},{"key":"2021042607591370400_R6","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1083\/jcb.200502113","article-title":"Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A","volume":"170","author":"Andersen","year":"2005","journal-title":"J. Cell Biol."},{"key":"2021042607591370400_R7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bbrc.2007.05.149","article-title":"TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase","volume":"359","author":"Besse","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042607591370400_R8","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.molcel.2009.12.039","article-title":"Regulation of translesion synthesis DNA polymerase eta by monoubiquitination","volume":"37","author":"Bienko","year":"2010","journal-title":"Mol. Cell"},{"key":"2021042607591370400_R9","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1128\/MCB.24.3.1219-1231.2004","article-title":"Drosophila melanogaster MNK\/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage","volume":"24","author":"Brodsky","year":"2004","journal-title":"Mol. Cell. 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Life Sci."},{"key":"2021042607591370400_R16","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1242\/dev.127.22.4763","article-title":"PAN GU: a protein kinase that inhibits S phase and promotes mitosis in early Drosophila development","volume":"127","author":"Fenger","year":"2000","journal-title":"Development"},{"key":"2021042607591370400_R17","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1242\/dev.120.8.2131","article-title":"The Drosophila maternal-effect mutation grapes causes a metaphase arrest at nuclear cycle 13","volume":"120","author":"Fogarty","year":"1994","journal-title":"Development"},{"key":"2021042607591370400_R18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nsmb.1776","article-title":"Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange","volume":"17","author":"Freudenthal","year":"2010","journal-title":"Nat. Struct. Mol. 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USA"},{"key":"2021042607591370400_R39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-0854.2010.01126.x","article-title":"The multiple facets of ubiquitination in the regulation of notch signaling pathway","volume":"12","author":"Le Bras","year":"2011","journal-title":"Traffic"},{"key":"2021042607591370400_R40","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1084\/jem.185.7.1275","article-title":"TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation","volume":"185","author":"Lee","year":"1997","journal-title":"J. Exp. Med."},{"key":"2021042607591370400_R41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.febslet.2004.11.029","article-title":"Replication of damaged DNA by translesion synthesis in human cells","volume":"579","author":"Lehmann","year":"2005","journal-title":"FEBS Lett."},{"key":"2021042607591370400_R42","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.dnarep.2007.02.003","article-title":"Translesion synthesis: Y-family polymerases and the polymerase switch","volume":"6","author":"Lehmann","year":"2007","journal-title":"DNA Repair (Amst.)"},{"key":"2021042607591370400_R43","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/genetics\/163.3.973","article-title":"The Drosophila chk2 gene loki is essential for embryonic DNA double-strand-break checkpoints induced in S phase or G2","volume":"163","author":"Masrouha","year":"2003","journal-title":"Genetics"},{"key":"2021042607591370400_R44","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/21447","article-title":"The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta","volume":"399","author":"Masutani","year":"1999","journal-title":"Nature"},{"key":"2021042607591370400_R45","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature02352","article-title":"Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity","volume":"428","author":"McCulloch","year":"2004","journal-title":"Nature"},{"key":"2021042607591370400_R46","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/genetics\/147.4.1557","article-title":"The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism","volume":"147","author":"McDonald","year":"1997","journal-title":"Genetics"},{"key":"2021042607591370400_R47","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1242\/dev.027599","article-title":"no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila","volume":"136","author":"Merkle","year":"2009","journal-title":"Development"},{"key":"2021042607591370400_R48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1128\/MCB.18.1.19","article-title":"Novel IkappaB alpha proteolytic pathway in WEHI231 immature B cells","volume":"18","author":"Miyamoto","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"2021042607591370400_R49","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1093\/nar\/gkh903","article-title":"REV1 accumulates in DNA damage-induced nuclear foci in human cells and is implicated in mutagenesis by benzo[a]pyrenediolepoxide","volume":"32","author":"Mukhopadhyay","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2021042607591370400_R50","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2443.2006.00938.x","article-title":"Analyses of ultraviolet-induced focus formation of hREV1 protein","volume":"11","author":"Murakumo","year":"2006","journal-title":"Genes Cells"},{"key":"2021042607591370400_R51","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0896-6273(93)90182-Q","article-title":"The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes","volume":"11","author":"Muralidhar","year":"1993","journal-title":"Neuron"},{"key":"2021042607591370400_R52","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ceb.2007.02.014","article-title":"Ubiquitin proteasome system (UPS): what can chromatin do for you?","volume":"19","author":"O\u2019Connell","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"2021042607591370400_R53","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1016\/j.cub.2003.12.022","article-title":"Embryonic cleavage cycles: how is a mouse like a fly?","volume":"14","author":"O\u2019Farrell","year":"2004","journal-title":"Curr. Biol."},{"key":"2021042607591370400_R54","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1242\/jcs.01603","article-title":"Localisation of human Y-family DNA polymerase kappa: relationship to PCNA foci","volume":"118","author":"Ogi","year":"2005","journal-title":"J. Cell Sci."},{"key":"2021042607591370400_R55","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1523\/JNEUROSCI.14-05-03166.1994","article-title":"bendless, a Drosophila gene affecting neuronal connectivity, encodes a ubiquitin-conjugating enzyme homolog","volume":"14","author":"Oh","year":"1994","journal-title":"J. Neurosci."},{"key":"2021042607591370400_R56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1247\/csf.31.29","article-title":"Deficiency of the Caenorhabditis elegans DNA polymerase eta homologue increases sensitivity to UV radiation during germ-line development","volume":"31","author":"Ohkumo","year":"2006","journal-title":"Cell Struct. Funct."},{"key":"2021042607591370400_R57","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.bbrc.2007.09.103","article-title":"Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene","volume":"363","author":"Park","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042607591370400_R58","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1096\/fasebj.11.13.9367341","article-title":"Targeting of substrates to the 26S proteasome","volume":"11","author":"Pickart","year":"1997","journal-title":"FASEB J."},{"key":"2021042607591370400_R59","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1084\/jem.20031187","article-title":"The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor","volume":"198","author":"Regamey","year":"2003","journal-title":"J. Exp. Med."},{"key":"2021042607591370400_R60","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1128\/MCB.00115-09","article-title":"Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication","volume":"29","author":"Rey","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"2021042607591370400_R61","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1242\/jcs.016626","article-title":"The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo","volume":"120","author":"Rickmyre","year":"2007","journal-title":"J. Cell Sci."},{"key":"2021042607591370400_R62","doi-asserted-by":"crossref","first-page":"e1002800","DOI":"10.1371\/journal.pgen.1002800","article-title":"A broad requirement for TLS polymerases \u03b7 and \u03ba, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis","volume":"8","author":"Roerink","year":"2012","journal-title":"PLoS Genet."},{"key":"2021042607591370400_R63","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0925-4773(98)00157-9","article-title":"Gal4 in the Drosophila female germline","volume":"78","author":"R\u00f8rth","year":"1998","journal-title":"Mech. 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Biol."},{"key":"2021042607591370400_R74","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0092-8674(03)00202-2","article-title":"Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity","volume":"113","author":"Takada","year":"2003","journal-title":"Cell"},{"key":"2021042607591370400_R75","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(94)90502-9","article-title":"Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain","volume":"78","author":"Treier","year":"1994","journal-title":"Cell"},{"key":"2021042607591370400_R76","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1038\/sj.emboj.7600383","article-title":"Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination","volume":"23","author":"Watanabe","year":"2004","journal-title":"EMBO J."},{"key":"2021042607591370400_R77","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1128\/MMBR.00034-08","article-title":"Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance","volume":"73","author":"Waters","year":"2009","journal-title":"Microbiol. 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