{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:00:37Z","timestamp":1790283637444,"version":"4.1.0"},"reference-count":14,"publisher":"The Company of Biologists","issue":"Supplement","license":[{"start":{"date-parts":[[1988,9,1]],"date-time":"1988-09-01T00:00:00Z","timestamp":589075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Craniofacial malformations have been recorded since time immemorial. While observational studies have assisted in the recognition of syndromes, little light has been shed on the causal mechanisms which interfere with craniofacial development. Animal studies in which malformations occur spontaneously or have been induced by teratogenic agents have permitted step-by-step investigation of such common deformities as cleft lip and palate. The role of the ectomesenchymal cells of the neural crest and the possible phenomenon of disorganized spontaneous cell death are described in relation to lip clefts. The factors associated with isolated cleft palate, Pierre Robin syndrome and submucous clefts are described by reference to animal models.<\/jats:p>\n               <jats:p>The haemorrhagic accident preceding the onset of craniofacial microsomia is discussed as is the distinctly different phenomenon of disturbance to the migration or differentiation of neural crest cells in the pathogenesis of Treacher Collins syndrome. The more severe anomalies of the calvarium such as plagiocephaly, Crouzon and Apert syndrome still defy explanation, in the absence of an appropriate animal system to study; some thoughts on the likely mechanism of abnormal sutural fusions are discussed.<\/jats:p>","DOI":"10.1242\/dev.103.supplement.207","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:38:11Z","timestamp":1619397491000},"page":"207-212","source":"Crossref","is-referenced-by-count":96,"title":["The aetiology and pathogenesis of craniofacial deformity"],"prefix":"10.1242","volume":"103","author":[{"given":"David","family":"Posw1llo","sequence":"first","affiliation":[{"name":"Guy\u2019s and St. Thomas\u2019 Hospitals Department of Oral and Maxillofacial Surgery, Guy\u2019s Tower (floor 24) , , London Bridge, London SEI 9RT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1988,9,1]]},"reference":[{"key":"2023121420260182500_DEVELOP_103_S_207C1","article-title":"Blebs and hematomas in the lips of CL\/Fr and A\/J mice","volume-title":"J. 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Rec"},{"key":"2023121420260182500_DEVELOP_103_S_207C13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/tera.1420010106","article-title":"Pathogenesis ofcleft lip and its relation to embryonic face shape in A\/J and C57B1 mice","volume":"1","author":"Trasler","year":"1968","journal-title":"Teratology"},{"key":"2023121420260182500_DEVELOP_103_S_207C14","first-page":"351","article-title":"The early development of the nasal cavity and upper lip in the human embryo","volume":"94","author":"Warbrick","year":"1960","journal-title":"J. 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