{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:29:17Z","timestamp":1791206957160,"version":"4.1.0"},"reference-count":31,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[1988,10,1]],"date-time":"1988-10-01T00:00:00Z","timestamp":591667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A single heat shock, given to 2-day-old chick embryos, can generate multiple but discrete somite and skeletal anomalies. Each of these anomalies is restricted to one, or at the most two, consecutive segments. The anomalies are separated from each other by a distance of 6\u20137 somites or vertebrae, or a multiple of this distance. These results argue against the \u2018clock and wavefront\u2019 model; while they support the idea of a cellular clock, they are not consistent with a single propagating wave gating cells destined to form each segment.<\/jats:p><jats:p>Heat shock also alters the size and number of segments, as well as the rostrocaudal proportions of the sclerotome. The results are consistent with the rostrocaudal fate of sclerotome cells being determined during segmentation. From our observations, we speculate on the implications for regionalization of the vertebral column.<\/jats:p>","DOI":"10.1242\/dev.104.2.331","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T18:23:00Z","timestamp":1619202180000},"page":"331-339","source":"Crossref","is-referenced-by-count":84,"title":["Heat shock causes repeated segmental anomalies in the chick embryo"],"prefix":"10.1242","volume":"104","author":[{"given":"D. R. N.","family":"Primmett","sequence":"first","affiliation":[{"name":"1 Department of Human Anatomy, South Parks Road, Oxford 0X1 3QX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. D.","family":"Stern","sequence":"additional","affiliation":[{"name":"1 Department of Human Anatomy, South Parks Road, Oxford 0X1 3QX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Keynes","sequence":"additional","affiliation":[{"name":"2 Department of Anatomy, Downing Street, Cambridge CB2 3 DY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1988,10,1]]},"reference":[{"key":"2023040617330145000_","first-page":"227","article-title":"The mechanism of somite segmentation in the chick embryo","volume":"51","author":"Bellairs","year":"1979","journal-title":"J. Embryol. exp. 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