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Cad99C, the Drosophila ortholog of human Usher protocadherin PCDH15, is expressed in several embryonic tubular epithelial structures. Through loss-of-function and overexpression studies, we show that Cad99C is required to regulate cell rearrangement during salivary tube elongation. We further show that overexpression of either Cad99C or SAS causes a dramatic increase in apical membrane at the expense of other membrane domains, and that both proteins can do this independently of each other and independently of mislocalization of the apical determinant Crumbs (Crb). Overexpression of Cad99C or SAS results in similar, but distinct effects, suggesting both shared and unique roles for these proteins in conferring apical identity.<\/jats:p>","DOI":"10.1242\/dev.104166","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T05:13:08Z","timestamp":1397106788000},"page":"1950-1960","source":"Crossref","is-referenced-by-count":29,"title":["Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation"],"prefix":"10.1242","volume":"141","author":[{"given":"SeYeon","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2196, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Andrew","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2196, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021052723535689100_DEV104166C2","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/S0092-8674(00)81800-0","article-title":"A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function","volume":"87","author":"Baumgartner","year":"1996","journal-title":"Cell"},{"key":"2021052723535689100_DEV104166C3","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/35001108","article-title":"Localization of apical epithelial determinants by the basolateral PDZ protein Scribble","volume":"403","author":"Bilder","year":"2000","journal-title":"Nature"},{"key":"2021052723535689100_DEV104166C4","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1242\/jcs.01619","article-title":"Papillote and Piopio: drosophila ZP-domain proteins required for cell adhesion to the apical extracellular matrix and microtubule organization","volume":"118","author":"B\u00f6kel","year":"2005","journal-title":"J. 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