{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:54:19Z","timestamp":1791917659221,"version":"4.3.4"},"reference-count":106,"publisher":"The Company of Biologists","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The mammalian kidney, the metanephros, is a mesodermal organ classically regarded as arising from the intermediate mesoderm (IM). Indeed, both the ureteric bud (UB), which gives rise to the ureter and the collecting ducts, and the metanephric mesenchyme (MM), which forms the rest of the kidney, derive from the IM. Based on an understanding of the signalling molecules crucial for IM patterning and kidney morphogenesis, several studies have now generated UB or MM, or both, in vitro via the directed differentiation of human pluripotent stem cells. Although these results support the IM origin of the UB and the MM, they challenge the simplistic view of a common progenitor for these two populations, prompting a reanalysis of early patterning events within the IM. Here, we review our understanding of the origin of the UB and the MM in mouse, and discuss how this impacts on kidney regeneration strategies and furthers our understanding of human development.<\/jats:p>","DOI":"10.1242\/dev.104802","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T12:56:03Z","timestamp":1432644963000},"page":"1937-1947","source":"Crossref","is-referenced-by-count":127,"title":["The origin of the mammalian kidney: implications for recreating the kidney <i>in vitro<\/i>"],"prefix":"10.1242","volume":"142","author":[{"given":"Minoru","family":"Takasato","sequence":"first","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia"},{"name":"Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa H.","family":"Little","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia"},{"name":"Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608013991600_DEV104802C1","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1101\/gad.855001","article-title":"The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures","volume":"15","author":"Abu-Abed","year":"2001","journal-title":"Genes Dev."},{"key":"2021042608013991600_DEV104802C2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1242\/dev.118.2.477","article-title":"FGF signalling in the early specification of mesoderm in Xenopus","volume":"118","author":"Amaya","year":"1993","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C3","doi-asserted-by":"publisher","first-page":"e62479","DOI":"10.1371\/journal.pone.0062479","article-title":"TCreERT2, a transgenic mouse line for temporal control of Cre-mediated recombination in lineages emerging from the primitive streak or tail bud","volume":"8","author":"Anderson","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042608013991600_DEV104802C4","doi-asserted-by":"publisher","first-page":"4143","DOI":"10.1242\/dev.085258","article-title":"Analysis of nephric duct specification in the avian embryo","volume":"139","author":"Attia","year":"2012","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C5","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1002\/dvdy.20263","article-title":"Cell fate specification along the anterior-posterior axis of the intermediate mesoderm","volume":"232","author":"Barak","year":"2005","journal-title":"Dev. Dyn."},{"key":"2021042608013991600_DEV104802C6","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.devcel.2012.04.018","article-title":"FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man","volume":"22","author":"Barak","year":"2012","journal-title":"Dev. Cell"},{"key":"2021042608013991600_DEV104802C7","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nature09151","article-title":"A random cell motility gradient downstream of FGF controls elongation of an amniote embryo","volume":"466","author":"B\u00e9naz\u00e9raf","year":"2010","journal-title":"Nature"},{"key":"2021042608013991600_DEV104802C8","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s00467-011-1843-8","article-title":"Human nephron number: implications for health and disease","volume":"26","author":"Bertram","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"2021042608013991600_DEV104802C9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1006\/dbio.1997.8812","article-title":"Murine cerberus homologue mCer-1: a candidate anterior patterning molecule","volume":"194","author":"Biben","year":"1998","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C10","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ydbio.2012.08.017","article-title":"Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo","volume":"371","author":"Boulet","year":"2012","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1432-0436.2006.00149.x","article-title":"In vitro differentiation of murine embryonic stem cells toward a renal lineage","volume":"75","author":"Bruce","year":"2007","journal-title":"Differentiation"},{"key":"2021042608013991600_DEV104802C12","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.devcel.2005.05.016","article-title":"Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system","volume":"9","author":"Carroll","year":"2005","journal-title":"Dev. Cell"},{"key":"2021042608013991600_DEV104802C13","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1097\/01.ASN.0000136779.17837.8F","article-title":"Identifying the molecular phenotype of renal progenitor cells","volume":"15","author":"Challen","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021042608013991600_DEV104802C14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.devcel.2009.07.013","article-title":"Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis","volume":"17","author":"Chi","year":"2009","journal-title":"Dev. Cell"},{"key":"2021042608013991600_DEV104802C15","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S1534-5807(01)00017-X","article-title":"FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak","volume":"1","author":"Ciruna","year":"2001","journal-title":"Dev. Cell"},{"key":"2021042608013991600_DEV104802C16","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1242\/dev.124.14.2829","article-title":"Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak","volume":"124","author":"Ciruna","year":"1997","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C17","doi-asserted-by":"publisher","first-page":"7986","DOI":"10.1158\/1078-0432.CCR-05-1354","article-title":"Clear cell sarcoma of the kidney: up-regulation of neural markers with activation of the sonic hedgehog and Akt pathways","volume":"11","author":"Cutcliffe","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"2021042608013991600_DEV104802C18","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1182\/blood-2007-06-093609","article-title":"Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors","volume":"111","author":"Davis","year":"2008","journal-title":"Blood"},{"key":"2021042608013991600_DEV104802C19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0896-6273(03)00565-8","article-title":"Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension","volume":"40","author":"del Corral","year":"2003","journal-title":"Neuron"},{"key":"2021042608013991600_DEV104802C20","doi-asserted-by":"publisher","first-page":"11343","DOI":"10.1073\/pnas.0502933102","article-title":"Control of the segmentation process by graded MAPK\/ERK activation in the chick embryo","volume":"102","author":"Delfini","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608013991600_DEV104802C21","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1242\/dev.01897","article-title":"Developmental regulation of the Hox genes during axial morphogenesis in the mouse","volume":"132","author":"Deschamps","year":"2005","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C22","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1093\/emboj\/17.15.4213","article-title":"Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice","volume":"17","author":"Dono","year":"1998","journal-title":"EMBO J."},{"key":"2021042608013991600_DEV104802C23","doi-asserted-by":"publisher","first-page":"3731","DOI":"10.1242\/dev.037689","article-title":"FGF signalling: diverse roles during early vertebrate embryogenesis","volume":"137","author":"Dorey","year":"2010","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C24","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0092-8674(01)00437-8","article-title":"FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal hox gene activation","volume":"106","author":"Dubrulle","year":"2001","journal-title":"Cell"},{"key":"2021042608013991600_DEV104802C25","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.cell.2008.09.002","article-title":"Retinoic acid synthesis and signaling during early organogenesis","volume":"134","author":"Duester","year":"2008","journal-title":"Cell"},{"key":"2021042608013991600_DEV104802C26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1242\/dev.009266","article-title":"Wnt3a\/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation","volume":"135","author":"Dunty","year":"2008","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C27","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1242\/dev.093740","article-title":"A role for Vg1\/Nodal signaling in specification of the intermediate mesoderm","volume":"140","author":"Fleming","year":"2013","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C28","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1242\/dev.00573","article-title":"Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo","volume":"130","author":"Forlani","year":"2003","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C29","doi-asserted-by":"publisher","first-page":"8668","DOI":"10.1073\/pnas.151258098","article-title":"Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression","volume":"98","author":"Galceran","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608013991600_DEV104802C30","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1002\/dvdy.22640","article-title":"Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules","volume":"240","author":"Georgas","year":"2011","journal-title":"Dev. Dyn."},{"key":"2021042608013991600_DEV104802C31","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1242\/dev.120.9.2673","article-title":"Embryonic expression and cloning of the murine GATA-3 gene","volume":"120","author":"George","year":"1994","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1242\/dev.02184","article-title":"Pax2\/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney","volume":"133","author":"Grote","year":"2006","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C33","doi-asserted-by":"publisher","first-page":"e1000316","DOI":"10.1371\/journal.pgen.1000316","article-title":"Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction","volume":"4","author":"Grote","year":"2008","journal-title":"PLoS Genet."},{"key":"2021042608013991600_DEV104802C34","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.ydbio.2007.08.021","article-title":"Cessation of renal morphogenesis in mice","volume":"310","author":"Hartman","year":"2007","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C35","first-page":"777","article-title":"Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle","volume":"64","author":"Hinchliffe","year":"1991","journal-title":"Lab. Invest."},{"key":"2021042608013991600_DEV104802C36","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1006\/dbio.1999.9463","article-title":"Adhesive subdivisions intrinsic to the epithelial somites","volume":"215","author":"Horikawa","year":"1999","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C37","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1006\/dbio.2002.0863","article-title":"Patterning of the avian intermediate mesoderm by lateral plate and axial tissues","volume":"253","author":"James","year":"2003","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C38","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ydbio.2005.09.025","article-title":"Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent manner","volume":"288","author":"James","year":"2005","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C39","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/gcc.22149","article-title":"Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin","volume":"53","author":"Karlsson","year":"2014","journal-title":"Genes Chromosom. Cancer"},{"key":"2021042608013991600_DEV104802C40","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1242\/dev.057646","article-title":"Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development","volume":"138","author":"Karner","year":"2011","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C41","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1681\/ASN.2005050544","article-title":"Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia","volume":"16","author":"Kim","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021042608013991600_DEV104802C42","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1242\/dev.126.21.4691","article-title":"The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo","volume":"126","author":"Kinder","year":"1999","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C43","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1242\/dev.128.18.3623","article-title":"The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm","volume":"128","author":"Kinder","year":"2001","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C44","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1126\/science.1085753","article-title":"Organizing axes in time and space; 25 years of colinear tinkering","volume":"301","author":"Kmita","year":"2003","journal-title":"Science"},{"key":"2021042608013991600_DEV104802C45","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1242\/dev.01858","article-title":"Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development","volume":"132","author":"Kobayashi","year":"2005","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C46","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbrc.2005.08.136","article-title":"Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells","volume":"336","author":"Kobayashi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042608013991600_DEV104802C47","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/0092-8674(93)90515-R","article-title":"WT-1 is required for early kidney development","volume":"74","author":"Kreidberg","year":"1993","journal-title":"Cell"},{"key":"2021042608013991600_DEV104802C48","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1242\/dev.109.4.775","article-title":"Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivatives of transgenic mice","volume":"109","author":"Kress","year":"1990","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C49","doi-asserted-by":"publisher","first-page":"2972","DOI":"10.1242\/dev.112367","article-title":"Retinoic acid controls body axis extension by directly repressing Fgf8 transcription","volume":"141","author":"Kumar","year":"2014","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C50","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/ki.1995.223","article-title":"The GATA-3 gene is expressed during human kidney embryogenesis","volume":"47","author":"Labastie","year":"1995","journal-title":"Kidney Int."},{"key":"2021042608013991600_DEV104802C51","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1681\/ASN.2013080831","article-title":"Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers","volume":"25","author":"Lam","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021042608013991600_DEV104802C52","doi-asserted-by":"publisher","first-page":"a008300","DOI":"10.1101\/cshperspect.a008300","article-title":"Mammalian kidney development: principles, progress, and projections","volume":"4","author":"Little","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2021042608013991600_DEV104802C53","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.modgep.2007.03.002","article-title":"A high-resolution anatomical ontology of the developing murine genitourinary tract","volume":"7","author":"Little","year":"2007","journal-title":"Gene Expr. Patterns."},{"key":"2021042608013991600_DEV104802C54","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.bbrc.2010.02.111","article-title":"Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells","volume":"393","author":"Mae","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042608013991600_DEV104802C55","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/ncomms2378","article-title":"Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells","volume":"4","author":"Mae","year":"2013","journal-title":"Nat. Commun."},{"key":"2021042608013991600_DEV104802C56","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1101\/gad.1962910","article-title":"Brachyury establishes the embryonic mesodermal progenitor niche","volume":"24","author":"Martin","year":"2010","journal-title":"Genes Dev."},{"key":"2021042608013991600_DEV104802C57","first-page":"515","article-title":"Nephron number: variability is the rule. Causes and consequences","volume":"79","author":"Merlet-B\u00e9nichou","year":"1999","journal-title":"Lab Invest."},{"key":"2021042608013991600_DEV104802C58","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1016\/j.bbrc.2009.10.148","article-title":"Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro","volume":"390","author":"Morizane","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042608013991600_DEV104802C59","doi-asserted-by":"publisher","first-page":"4018","DOI":"10.1073\/pnas.1007417108","article-title":"FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis","volume":"108","author":"Naiche","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608013991600_DEV104802C60","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/ki.2012.442","article-title":"Human embryonic stem cells differentiate into functional renal proximal tubular-like cells","volume":"83","author":"Narayanan","year":"2013","journal-title":"Kidney Int."},{"key":"2021042608013991600_DEV104802C61","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/nprot.2008.42","article-title":"A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies","volume":"3","author":"Ng","year":"2008","journal-title":"Nat. Protoc."},{"key":"2021042608013991600_DEV104802C62","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/7788","article-title":"Embryonic retinoic acid synthesis is essential for early mouse post-implantation development","volume":"21","author":"Niederreither","year":"1999","journal-title":"Nat. Genet."},{"key":"2021042608013991600_DEV104802C63","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.bbrc.2011.12.071","article-title":"Stepwise renal lineage differentiation of mouse embryonic stem cells tracing in vivo development","volume":"417","author":"Nishikawa","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042608013991600_DEV104802C64","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1242\/dev.126.6.1103","article-title":"The surface ectoderm is essential for nephric duct formation in intermediate mesoderm","volume":"126","author":"Obara-Ishihara","year":"1999","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C65","doi-asserted-by":"publisher","first-page":"5672","DOI":"10.1073\/pnas.95.10.5672","article-title":"Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2","volume":"95","author":"Ortega","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608013991600_DEV104802C66","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/dvg.1020170104","article-title":"Regionalisation of cell fate and morphogenetic movement of the mesoderm during mouse gastrulation","volume":"17","author":"Parameswaran","year":"1995","journal-title":"Dev. Genet."},{"key":"2021042608013991600_DEV104802C67","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/S0959-437X(02)00319-2","article-title":"The GATA family (vertebrates and invertebrates)","volume":"12","author":"Patient","year":"2002","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2021042608013991600_DEV104802C68","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/dvdy.10474","article-title":"Atlas of Hox gene expression in the developing kidney","volume":"229","author":"Patterson","year":"2004","journal-title":"Dev. Dyn."},{"key":"2021042608013991600_DEV104802C69","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1242\/dev.035592","article-title":"Interplay between activin and Hox genes determines the formation of the kidney morphogenetic field","volume":"136","author":"Preger-Ben Noon","year":"2009","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C70","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1006\/dbio.1996.8443","article-title":"Developmental defects in mouse embryos lacking N-cadherin","volume":"181","author":"Radice","year":"1997","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C71","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1093\/abbs\/gmq046","article-title":"Differentiation of murine embryonic stem cells toward renal lineages by conditioned medium from ureteric bud cells in vitro","volume":"42","author":"Ren","year":"2010","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"2021042608013991600_DEV104802C72","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1101\/gad.5.8.1333","article-title":"Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis","volume":"5","author":"Rossant","year":"1991","journal-title":"Genes Dev."},{"key":"2021042608013991600_DEV104802C73","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ydbio.2011.09.011","article-title":"Nephron formation adopts a novel spatial topology at cessation of nephrogenesis","volume":"360","author":"Rumballe","year":"2011","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C74","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1242\/dev.124.7.1293","article-title":"Differential regulation of two sets of mesonephric tubules by WT-1","volume":"124","author":"Sainio","year":"1997","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C75","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.ydbio.2005.05.029","article-title":"Eya1 acts as a critical regulator for specifying the metanephric mesenchyme","volume":"284","author":"Sajithlal","year":"2005","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C76","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1101\/gad.851501","article-title":"The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo","volume":"15","author":"Sakai","year":"2001","journal-title":"Genes Dev."},{"key":"2021042608013991600_DEV104802C77","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511565083","volume-title":"Organogenesis of the Kidney","author":"Saxen","year":"1987"},{"key":"2021042608013991600_DEV104802C78","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0925-4773(99)00093-3","article-title":"Expression of Fgf4 during early development of the chick embryo","volume":"85","author":"Shamim","year":"1999","journal-title":"Mech. Dev."},{"key":"2021042608013991600_DEV104802C79","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0925-4773(99)00150-1","article-title":"Gata2 and Gata3: novel markers for early embryonic polarity and for non-neural ectoderm in the chick embryo","volume":"87","author":"Sheng","year":"1999","journal-title":"Mech. Dev."},{"key":"2021042608013991600_DEV104802C80","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.devcel.2014.02.017","article-title":"Global quantification of tissue dynamics in the developing mouse kidney","volume":"29","author":"Short","year":"2014","journal-title":"Dev. Cell"},{"key":"2021042608013991600_DEV104802C81","doi-asserted-by":"publisher","first-page":"e46453","DOI":"10.1371\/journal.pone.0046453","article-title":"The directed differentiation of human iPS cells into kidney podocytes","volume":"7","author":"Song","year":"2012","journal-title":"PLoS ONE"},{"key":"2021042608013991600_DEV104802C82","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1126\/science.1171468","article-title":"Epigenetic temporal control of mouse Hox genes in vivo","volume":"324","author":"Soshnikova","year":"2009","journal-title":"Science"},{"key":"2021042608013991600_DEV104802C83","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1681\/ASN.2004070584","article-title":"Integration of embryonic stem cells in metanephric kidney organ culture","volume":"16","author":"Steenhard","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021042608013991600_DEV104802C84","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1471-213X-8-63","article-title":"The migration of paraxial and lateral plate mesoderm cells emerging from the late primitive streak is controlled by different Wnt signals","volume":"8","author":"Sweetman","year":"2008","journal-title":"BMC Dev. Biol."},{"key":"2021042608013991600_DEV104802C85","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.stem.2013.11.010","article-title":"Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells","volume":"14","author":"Taguchi","year":"2014","journal-title":"Cell Stem Cell"},{"key":"2021042608013991600_DEV104802C86","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1101\/gad.8.2.174","article-title":"Wnt-3a regulates somite and tailbud formation in the mouse embryo","volume":"8","author":"Takada","year":"1994","journal-title":"Genes Dev."},{"key":"2021042608013991600_DEV104802C87","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"2021042608013991600_DEV104802C88","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/ncb2894","article-title":"Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney","volume":"16","author":"Takasato","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"2021042608013991600_DEV104802C89","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00467-013-2592-7","article-title":"Recreating kidney progenitors from pluripotent cells","volume":"29","author":"Takasato","year":"2014","journal-title":"Pediatr. Nephrol."},{"key":"2021042608013991600_DEV104802C90","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1242\/dev.127.23.5059","article-title":"Early myotome specification regulates PDGFA expression and axial skeleton development","volume":"127","author":"Tallquist","year":"2000","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C91","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"2021042608013991600_DEV104802C92","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/jmor.1051200203","article-title":"Morphogenesis and histochemistry of the developing mouse kidney","volume":"120","author":"Vetter","year":"1966","journal-title":"J. Morphol."},{"key":"2021042608013991600_DEV104802C93","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1681\/ASN.2006101078","article-title":"Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo","volume":"18","author":"Vigneau","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021042608013991600_DEV104802C94","doi-asserted-by":"publisher","first-page":"4033","DOI":"10.1242\/dev.009167","article-title":"FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis","volume":"134","author":"Wahl","year":"2007","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C95","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1101\/gad.993302","article-title":"Hox11 paralogous genes are essential for metanephric kidney induction","volume":"16","author":"Wellik","year":"2002","journal-title":"Genes Dev."},{"key":"2021042608013991600_DEV104802C96","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.ydbio.2005.07.016","article-title":"Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse","volume":"286","author":"Wijgerde","year":"2005","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C97","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-540-76341-3_1","article-title":"Embryology","volume-title":"Pediatric Nephrology","author":"Woolf","year":"2009"},{"key":"2021042608013991600_DEV104802C98","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1038\/ncb2872","article-title":"Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells","volume":"15","author":"Xia","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"2021042608013991600_DEV104802C99","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.devcel.2014.10.015","article-title":"Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis","volume":"31","author":"Xu","year":"2014","journal-title":"Dev. Cell"},{"key":"2021042608013991600_DEV104802C100","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1242\/dev.126.6.1211","article-title":"A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo","volume":"126","author":"Yamaguchi","year":"1999","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C101","doi-asserted-by":"publisher","first-page":"F52","DOI":"10.1152\/ajprenal.00001.2004","article-title":"Branching ducts similar to mesonephric ducts or ureteric buds in teratomas originating from mouse embryonic stem cells","volume":"290","author":"Yamamoto","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2021042608013991600_DEV104802C102","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S1534-5807(02)00256-3","article-title":"Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8","volume":"3","author":"Yang","year":"2002","journal-title":"Dev. Cell"},{"key":"2021042608013991600_DEV104802C103","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1242\/dev.023416","article-title":"PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression","volume":"135","author":"Yang","year":"2008","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C104","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1242\/dev.124.13.2561","article-title":"Induction of cardiac myogenesis in avian pregastrula epiblast: the role of the hypoblast and activin","volume":"124","author":"Yatskievych","year":"1997","journal-title":"Development"},{"key":"2021042608013991600_DEV104802C105","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1006\/dbio.1997.8502","article-title":"Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse","volume":"183","author":"Yoshikawa","year":"1997","journal-title":"Dev. Biol."},{"key":"2021042608013991600_DEV104802C106","doi-asserted-by":"publisher","first-page":"6807","DOI":"10.1093\/hmg\/ddu397","article-title":"Non-canonical Wnt5a\/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension","volume":"23","author":"Yun","year":"2014","journal-title":"Hum. Mol. Genet."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/142\/11\/1937\/1693259\/dev104802.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/142\/11\/1937\/1693259\/dev104802.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T12:38:09Z","timestamp":1619440689000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/142\/11\/1937\/46768\/The-origin-of-the-mammalian-kidney-implications"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,1]]},"references-count":106,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,6,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.104802","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6,1]]}}}