{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:04:03Z","timestamp":1760385843619},"reference-count":57,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Previous studies have demonstrated the presence of type II collagen (in mature chickens predominantly a \u2018carti-lage-specific\u2019 collagen) in a variety of embryonic extra-cellular matrices that separate epithelia from mesen-chyme. In an immunohistochemical study using collagen type-specific monoclonal antibodies, we asked whether type IX collagen, another \u2018cartilage-specific\u2019 collagen, is coexpressed along with type II at such interfaces. We confirmed that, in the matrix underlying a variety of cranial ectodermal derivatives and along the ventro-lateral surfaces of neuroepithelia, type II collagen is codistributed with collagen types I and IV. Type IX collagen, however, was undetectable at those sites. We observed immunoreactivity for type IX collagen only within the notochordal sheath, where it first appeared at a later stage than did collagen types I and II. We also observed type II collagen (without type IX) beneath the dorsolateral ectoderm at stage 16; this correlates with the period during which limb ectoderm has been reported to induce the mesoderm to become chondro-genic. Finally, in older hind limbs we observed subepith-elial type II collagen that was not associated with subsequent chondrogenesis, but appeared to parallel the formation of feathers and scales in the developing limb. These observations suggest that the deposition of collagen types II and IX into interfacial matrices is regulated independently, and that induction of mesenchymal chondrogenesis by such matrices does not involve type IX collagen. Subepithelial type IX collagen deposition, on the other hand, correlates with the assembly of a thick multilaminar fibrillar matrix, as present in the notochordal sheath and, as shown previously, in the corneal primary stroma.<\/jats:p>","DOI":"10.1242\/dev.105.1.85","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T18:23:42Z","timestamp":1619202222000},"page":"85-95","source":"Crossref","is-referenced-by-count":50,"title":["Independent deposition of collagen types II and IX at epithelial\u2013mesenchymal interfaces"],"prefix":"10.1242","volume":"105","author":[{"given":"John M.","family":"Fitch","sequence":"first","affiliation":[{"name":"Tufts University School of Medicine 1 Department of Anatomy and Cellular Biology , , Dental Medicine and Veterinary Medicine, 136 Harrison Avenue, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Mentzer","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine 1 Department of Anatomy and Cellular Biology , , Dental Medicine and Veterinary Medicine, 136 Harrison Avenue, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Mayne","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham 2 Department of Cell Biology and Anatomy , , Birmingham, Alabama 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Linsenmayer","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine 1 Department of Anatomy and Cellular Biology , , Dental Medicine and Veterinary Medicine, 136 Harrison Avenue, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1989,1,1]]},"reference":[{"key":"2023050311114934000_DEVELOP_105_1_85C1","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0014-4835(61)80016-X","article-title":"Glycosaminoglycans in the developing corneal stroma","volume":"1","author":"Anseth","year":"1961","journal-title":"Expl Eye Res"},{"key":"2023050311114934000_DEVELOP_105_1_85C2","first-page":"383","article-title":"The development of the notochord in the chick embryo, studied by scanning and transmission electron microscopy","volume":"35","author":"Bancroft","year":"1976","journal-title":"J. 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