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Results show that SCs are required: (1) to maintain the differentiated phenotype of peritubular myoid cells (PTMCs) in prepubertal life; (2) to maintain the ALC progenitor population in the postnatal testis; and (3) for development of normal ALC numbers. Furthermore, our data show that fetal LCs function independently from SC, germ cell or PTMC support in the prepubertal testis. Together, these findings reveal that SCs remain essential regulators of testis development long after the period of sex determination. These findings have significant implications for our understanding of male reproductive disorders and wider androgen-related conditions affecting male health.<\/jats:p>","DOI":"10.1242\/dev.107029","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T11:28:34Z","timestamp":1399375714000},"page":"2139-2149","source":"Crossref","is-referenced-by-count":144,"title":["Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis"],"prefix":"10.1242","volume":"141","author":[{"given":"Diane","family":"Rebourcet","sequence":"first","affiliation":[{"name":"MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"O'Shaughnessy","sequence":"additional","affiliation":[{"name":"Institute of Biodiversity, Animal Health and Comparative 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