{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:16:12Z","timestamp":1760710572829},"reference-count":34,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The growth of optic axons towards experimentally rotated tecta has been studied. In stage 24\/25 embryos, a piece of the dorsal neural tube, containing the dorsal midbrain rudiment, was rotated through 180\u00b0. At later stages of development, the pathways of growing optic axons were investigated by labelling with either horseradish peroxidase or fluorescent dye. It is shown that retinal ganglion cell axons followed well-defined pathways, in spite of the abnormal structure of the brain, and were able to locate displaced tecta. This directed outgrowth of retinal axons in the optic tracts appears to be related either to the tectum or to some other component included in the graft operations. In tadpoles in which the midbrain rudiment was removed, optic axons still followed the normal course of the optic tract. This observation argues against long-range target attraction as being essential in guiding growing retinal axons towards the tectum. An alternative axon guidance mechanism, selective fasciculation, is discussed as a possible alternative to exaplain the directed axon outgrowth which occurs in both the normal and in these experimentally manipulated tadpoles.<\/jats:p>","DOI":"10.1242\/dev.108.1.147","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:40:00Z","timestamp":1619397600000},"page":"147-158","source":"Crossref","is-referenced-by-count":31,"title":["The directed growth of retinal axons towards surgically transposed tecta in <i>Xenopus;<\/i> an examination of homing behaviour by retinal ganglion cell axons"],"prefix":"10.1242","volume":"108","author":[{"given":"J. S. H.","family":"Taylor","sequence":"first","affiliation":[{"name":"University of Oxford Department of Human Anatomy , , South Parks Road, Oxford, 0X13QX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1990,1,1]]},"reference":[{"key":"2023050311335748000_DEVELOP_108_1_147C1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0306-4522(77)90074-4","article-title":"Technical considerations on the use of HRP as a neuronal marker","volume":"2","author":"Adams","year":"1977","journal-title":"Neurosci"},{"key":"2023050311335748000_DEVELOP_108_1_147C2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/0012-1606(84)90326-9","article-title":"Homotopic and heterotopic transplantations of quail tectal primordia in chick embryos: Organisation of the retinotectal projection in chimeric embryos","volume":"103","author":"Alvarado-Mallart","year":"1984","journal-title":"Devl Biol"},{"key":"2023050311335748000_DEVELOP_108_1_147C3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1098\/rspb.1978.0050","article-title":"Observations on the formation of brain and of nerve connections following embryonic manipulation of the amphibian neural tube","volume":"201","author":"Chung","year":"1978","journal-title":"Proc. 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