{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:43:30Z","timestamp":1773290610561,"version":"3.50.1"},"reference-count":49,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The fate of parthenogenetic cells was investigated during development of fetal and early postnatal chimeras. On day 13 of embryonic development, considerable contribution of parthenogenetic cells was observed in all tissues of chimeric embryos, although selection against parthenogenetic cells seemed to start before day 13. Between days 13 and 15 of development, parthenogenetic cells came under severe selective pressure, which was most striking in tongue. The disappearance of parthenogenetic cells from tongue coincided with the beginning of myoblast fusion in this tissue. Severe selection against parthenogenetic cells was also observed in pancreas and liver, although in the latter, parthenogenetic cells were eliminated later than in skeletal muscle or pancreas. In other tissues, parthenogenetic cells may persist and participate to a considerable extent throughout the gestation period and beyond, although a significant decrease was observed in all tissues. Parthenogen-etic\u2194fertilized chimeras were significantly smaller than their non-chimeric littermates at all developmental stages. These results suggest that the absence of paternal chromosomes is largely incompatible with the maintenance of specific differentiated cell types. Furthermore, paternally derived genes seem to be involved in the regulation of proliferation of all cell types, as indicated by the drastic growth deceleration of parthenogen-etic\u2194fertilized chimeras and the overall decrease of parthenogenetic cells during fetal development. Chromosomal imprinting may have a role in maintaining a balance between cell growth and differentiation during embryonic development.<\/jats:p>\n               <jats:p>The major exception to the selective elimination of parthenogenetic cells appear to be the germ cells; viable offspring derived from parthenogenetic oocytes were detected, sometimes at a high frequency in litters of female parthenogenetic\u2194fertilized chimeras.<\/jats:p>","DOI":"10.1242\/dev.108.1.203","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:40:05Z","timestamp":1619397605000},"page":"203-211","source":"Crossref","is-referenced-by-count":90,"title":["Temporal and spatial selection against parthenogenetic cells during development of fetal chimeras"],"prefix":"10.1242","volume":"108","author":[{"given":"Reinald H.","family":"Fundele","sequence":"first","affiliation":[{"name":"AFRC Institute of Animal Physiology and Genetics Research 1 Department of Molecular Embryology , , Babraham, Cambridge CB2 4AT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Norris","sequence":"additional","affiliation":[{"name":"AFRC Institute of Animal Physiology and Genetics Research 1 Department of Molecular Embryology , , Babraham, Cambridge CB2 4AT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila C.","family":"Barton","sequence":"additional","affiliation":[{"name":"AFRC Institute of Animal Physiology and Genetics Research 1 Department of Molecular Embryology , , Babraham, Cambridge CB2 4AT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Fehlau","sequence":"additional","affiliation":[{"name":"Physikalische Biochemie und Zellbiologie der University 2 Institut fiir Physiologische Chemie , , Goethestr. 33, 8000 M\u00fcnchen 2, FRG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah K.","family":"Howlett","sequence":"additional","affiliation":[{"name":"AFRC Institute of Animal Physiology and Genetics Research 1 Department of Molecular Embryology , , Babraham, Cambridge CB2 4AT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter E.","family":"Mills","sequence":"additional","affiliation":[{"name":"AFRC Institute of Animal Physiology and Genetics Research 1 Department of Molecular Embryology , , Babraham, Cambridge CB2 4AT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Azim","family":"Surani","sequence":"additional","affiliation":[{"name":"AFRC Institute of Animal Physiology and Genetics Research 1 Department of Molecular Embryology , , Babraham, Cambridge CB2 4AT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1990,1,1]]},"reference":[{"key":"2023050311332700200_DEVELOP_108_1_203C1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0092-8674(88)90391-1","article-title":"Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons","volume":"53","author":"Alpert","year":"1988","journal-title":"Cell"},{"key":"2023050311332700200_DEVELOP_108_1_203C2","doi-asserted-by":"publisher","first-page":"6509","DOI":"10.1073\/pnas.83.17.6509","article-title":"Successful rescue of microsurgically produced homozygous uniparental mouse embryos via production of aggregation chimeras","volume":"83","author":"Anderegg","year":"1986","journal-title":"Proc. natn. Acad. Sci. U. S. A"},{"key":"2023050311332700200_DEVELOP_108_1_203C3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1471-0528.1982.tb04692.x","article-title":"Unmasking moles","volume":"89","author":"Bagshawe","year":"1982","journal-title":"Br. J. Obstet. Gynaecol"},{"key":"2023050311332700200_DEVELOP_108_1_203C4","first-page":"267","article-title":"Development of gynogenetic and parthenogenetic inner cell mass and trophectoderm tissues in reconstituted blastocysts in the mouse","volume":"90","author":"Barton","year":"1985","journal-title":"J. Embryol. exp. Morph"},{"key":"2023050311332700200_DEVELOP_108_1_203C5","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/311374a0","article-title":"Role of paternal and maternal genomes in mouse development","volume":"311","author":"Barton","year":"1984","journal-title":"Nature, Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C6","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0014-5793(80)81197-5","article-title":"Quantitative evaluation of electrophoretic allo- and isozyme patterns","volume":"115","author":"B\u00dbcher","year":"1980","journal-title":"FEBS Lett"},{"issue":"Supplement","key":"2023050311332700200_DEVELOP_108_1_203C7","first-page":"137","article-title":"Parental origin effects in mice","volume":"97","author":"Cattanach","year":"1986","journal-title":"J. Embryol. exp. Morph"},{"key":"2023050311332700200_DEVELOP_108_1_203C8","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/315496a0","article-title":"Differential activity of maternally and paternally derived chromosome regions in mice","volume":"315","author":"Cattanach","year":"1985","journal-title":"Nature. Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C9","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/305779a0","article-title":"Expression of recessive alleles by chromosomal mechanisms in retinoblastoma","volume":"305","author":"Cavenee","year":"1983","journal-title":"Nature. Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1242\/dev.104.1.175","article-title":"The developmental potential of parthenogenetically-derived cells in chimeric mouse embryos: Implications for action of imprinted genes","volume":"104","author":"Clarke","year":"1988","journal-title":"Development"},{"key":"2023050311332700200_DEVELOP_108_1_203C11","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/0012-1606(84)90156-8","article-title":"Mouse trisomy 16 as an animal model of human trisomy 21 (Down Syndrome): Production of viable trisomy 16\u2194-Hiiploid mouse chimeras","volume":"101","author":"Cox","year":"1984","journal-title":"Devi Biol"},{"key":"2023050311332700200_DEVELOP_108_1_203C12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/jez.1402260217","article-title":"Parthenogenetic activation of mouse oocytes in vitro with ethanol and benzyl alcohol","volume":"226","author":"Cuthbertson","year":"1983","journal-title":"J. exp. Zool"},{"key":"2023050311332700200_DEVELOP_108_1_203C13","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/339556a0","article-title":"Parental origin of mutations of the retinoblastoma gene","volume":"339","author":"Dryja","year":"1989","journal-title":"Nature, Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C14","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1073\/pnas.75.2.946","article-title":"Assignment of genes to regions of mouse chromosomes","volume":"75","author":"Eicher","year":"1978","journal-title":"Proc. natn. Acad. Sci. U. S. A"},{"key":"2023050311332700200_DEVELOP_108_1_203C15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/dvg.1020040303","article-title":"Production and properties of mouse trisomy 15\u2194-&gt;diploid chimeras","volume":"4","author":"Epstein","year":"1984","journal-title":"Devi Genet"},{"key":"2023050311332700200_DEVELOP_108_1_203C16","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1073\/pnas.79.14.4376","article-title":"Production of viable adult trisomy 17 &lt;-&gt; diploid mouse chimeras","volume":"79","author":"Epstein","year":"1982","journal-title":"Proc. natn. Acad. Sci. U. S. A"},{"key":"2023050311332700200_DEVELOP_108_1_203C17","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1677\/joe.0.0150374","article-title":"Induction of superovulation and pregnancy in mature mice by gonadrotrophins","volume":"15","author":"Fowler","year":"1957","journal-title":"J. Endocrin"},{"key":"2023050311332700200_DEVELOP_108_1_203C18","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/BF00848319","article-title":"Viability of trisomy 12 cells in mouse chimaeras","volume":"194","author":"F\u00fandele","year":"1985","journal-title":"Roux\u2019s Arch, devl Biol"},{"key":"2023050311332700200_DEVELOP_108_1_203C19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1242\/dev.106.1.29","article-title":"Systematic elimination of parthenogenetic cells in mouse chimeras","volume":"106","author":"F\u00fandele","year":"1989","journal-title":"Development"},{"key":"2023050311332700200_DEVELOP_108_1_203C20","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1242\/dev.101.4.915","article-title":"Nuclear cytoplasmic interactions following nuclear transplantation in mouse embryos","volume":"101","author":"Howlett","year":"1987","journal-title":"Development"},{"key":"2023050311332700200_DEVELOP_108_1_203C21","first-page":"387","article-title":"Development of parthenogenetic and fertilized mouse embryos in the uterus and in extra-uterine sites","volume-title":"J. Embryol. exp. Morph.","author":"Iles","year":"1975"},{"key":"2023050311332700200_DEVELOP_108_1_203C22","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/268633a0","article-title":"Androgenetic origins of hydatidiform moles","volume":"268","author":"Kajii","year":"1977","journal-title":"Nature, Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C23","first-page":"139","article-title":"The chromosome complement of single-pronuclear haploid mouse embryos following activation by alcohol","volume":"71","author":"Kaufman","year":"1982","journal-title":"J. Embryol. exp. Morph"},{"key":"2023050311332700200_DEVELOP_108_1_203C24","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/316330a0","article-title":"Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism","volume":"316","author":"Koufos","year":"1985","journal-title":"Nature, Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C25","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1432-0436.1984.tb01375.x","article-title":"Parental source of chromosome imprinting and its relevance for X chromosome inactivation","volume":"26","author":"Lyon","year":"1984","journal-title":"Differentiation"},{"key":"2023050311332700200_DEVELOP_108_1_203C26","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0092-8674(84)90313-1","article-title":"Completion of mouse embryogenesis requires both the maternal and paternal genomes","volume":"37","author":"McGrath","year":"1984","journal-title":"Cell"},{"key":"2023050311332700200_DEVELOP_108_1_203C27","article-title":"Hemopoietic cells","volume-title":"Frontiers of Biology","author":"Metcalf","year":"1971"},{"key":"2023050311332700200_DEVELOP_108_1_203C28","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1242\/dev.101.1.67","article-title":"Prenatal fate of parthenogenetic cells in mouse aggregation chimeras","volume":"101","author":"Nagy","year":"1987","journal-title":"Development"},{"key":"2023050311332700200_DEVELOP_108_1_203C29","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1242\/dev.106.2.321","article-title":"Systematic nonuniform distribution of parthenogenetic cells in adult mouse chimeras","volume":"106","author":"Nagy","year":"1989","journal-title":"Development"},{"key":"2023050311332700200_DEVELOP_108_1_203C30","first-page":"279","article-title":"Induction of triploidy in the mouse by cytochalasin B","volume":"34","author":"Niemierko","year":"1975","journal-title":"J. Embryol. exp. Morph"},{"key":"2023050311332700200_DEVELOP_108_1_203C31","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/j.1440-169X.1987.00373.x","article-title":"Pluripotency of homozygous-diploid mouse embryos in chimeras","volume":"29","author":"Otani","year":"1987","journal-title":"Develop. Growth Differ"},{"key":"2023050311332700200_DEVELOP_108_1_203C32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1242\/dev.105.1.115","article-title":"Postnatal development of parthenogenetic\u2194fertilized mouse aggregation chimeras","volume":"105","author":"Paldi","year":"1989","journal-title":"Development"},{"key":"2023050311332700200_DEVELOP_108_1_203C33","first-page":"297","article-title":"X-chromosome instability in pluripotential stem cell lines derived from parthenogenetic embryos","volume":"74","author":"Robertson","year":"1983","journal-title":"J. Embryol. exp. Morph"},{"key":"2023050311332700200_DEVELOP_108_1_203C34","first-page":"413","article-title":"Nonrandom loss of maternal chromosome 11 alleles in Wilm\u2019s tumors","volume":"40","author":"Schroeder","year":"1987","journal-title":"Am. J. Hum. Genet"},{"key":"2023050311332700200_DEVELOP_108_1_203C35","doi-asserted-by":"publisher","first-page":"5099","DOI":"10.1073\/pnas.72.12.5099","article-title":"Immunosurgery of mouse blastocyst","volume":"72","author":"Solter","year":"1975","journal-title":"Proc. natn. Acad. Sci. U. S. A"},{"key":"2023050311332700200_DEVELOP_108_1_203C36","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/276266a0","article-title":"Totipotent cells of parthenogenetic origin in a chimaeric mouse","volume":"276","author":"Stevens","year":"1978","journal-title":"Nature, Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C37","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/269515a0","article-title":"Viable chimaeras produced from normal and parthenogenetic mouse embryos","volume":"269","author":"Stevens","year":"1977","journal-title":"Nature, Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C38","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1242\/dev.103.1.171","article-title":"Influence of chromosomal determinants on development of androgenetic and parthenogenetic cells","volume":"103","author":"Surani","year":"1988","journal-title":"Development"},{"key":"2023050311332700200_DEVELOP_108_1_203C39","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/270601a0","article-title":"Development to term of chimaeras between diploid parthenogenetic and fertilized embryos","volume":"270","author":"Surani","year":"1977","journal-title":"Nature, Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C40","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/308548a0","article-title":"Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis","volume":"308","author":"Surani","year":"1984","journal-title":"Nature, Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C41","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/326395a0","article-title":"Influence of parental chromosomes on spatial specificity in androgenetic\u2194parthenogenetic chimaeras in the mouse","volume":"326","author":"Surani","year":"1987","journal-title":"Nature, Lond"},{"issue":"Supplement","key":"2023050311332700200_DEVELOP_108_1_203C42","first-page":"123","article-title":"Influence of germline modifications of homologous chromosomes on mouse development","volume":"97","author":"Surani","year":"1986","journal-title":"J. Embryol. exp. Morph"},{"key":"2023050311332700200_DEVELOP_108_1_203C43","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/256640a0","article-title":"Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse","volume":"256","author":"Tagaki","year":"1975","journal-title":"Nature, Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C44","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1101\/gad.2.10.1344","article-title":"The developmental fate of androgenetic, parthenogenetic, and gynogenetic cells in chimeric gastrulating mouse embryos","volume":"2","author":"Thomson","year":"1988","journal-title":"Genes & Development"},{"key":"2023050311332700200_DEVELOP_108_1_203C45","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/S0012-1606(89)80028-4","article-title":"Chimeras between parthenogenetic or androgenetic blastomeres and normal embryos: Allocation to the inner cell mass and trophectoderm","volume":"131","author":"Thomson","year":"1989","journal-title":"Devi Biol"},{"key":"2023050311332700200_DEVELOP_108_1_203C46","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/338156a0","article-title":"Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma","volume":"338","author":"Toguchida","year":"1989","journal-title":"Nature, Lond"},{"key":"2023050311332700200_DEVELOP_108_1_203C47","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/0012-1606(68)90073-0","article-title":"Ultrastructural studies of early morphogenesis and cytodifferentiation in the embryonic mammalian pancreas","volume":"17","author":"Wessels","year":"1968","journal-title":"Devi Biol"},{"key":"2023050311332700200_DEVELOP_108_1_203C48","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1071\/BI9691065","article-title":"Storage of two cell mouse embryos in vitro","volume":"22","author":"Whittingham","year":"1969","journal-title":"Aust. J. Biol. Sci"},{"key":"2023050311332700200_DEVELOP_108_1_203C49","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/340312a0","article-title":"Preferential germline mutation of the paternal allele in retinoblastoma","volume":"340","author":"Zhu","year":"1989","journal-title":"Nature, Lond"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/108\/1\/203\/2803183\/develop_108_1_203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/108\/1\/203\/2803183\/develop_108_1_203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T11:39:00Z","timestamp":1683113940000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/108\/1\/203\/36340\/Temporal-and-spatial-selection-against"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.108.1.203","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1,1]]}}}