{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:09:58Z","timestamp":1789510198266,"version":"build-2803163510"},"reference-count":42,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[1990,2,1]],"date-time":"1990-02-01T00:00:00Z","timestamp":633830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Studies on eyelid opening and incisor eruption in 216 neonatal Tabby (Ta)-bearlng mice and wildtype controls (35 Ta\/Y, 62 +\/Y, 30 Ta\/Ta, 57 Ta\/+ and 32 +\/+) showed that in animals hemizygous and homozygous for Ta, the timing of eyelid opening and incisor eruption was significantly delayed (P&amp;lt;0.05). It was also observed that once open, the eyes of mutant pups do not remain open for long but soon close again for several days before reopening. An iterative eyes open-eyes closed process seems to continue beyond puberty. Studies In 25 epidermal growth factor (EGF)-treated mutants and 23 saline-treated controls showed that neonatal EGF injections (4\u03bcg g-1 body weight per day) reversed the delayed timing of eyelid opening and incisor eruption in hemizy gote and homozygote Tabby mice. However, both mutant and wildtype EGF-treated mice also showed the eyes open-eyes closed cycle, whereas untreated nonmutant mice did not. Because Tabby appears to be genetically homologous to the gene for human X-linked hypohidrotic ectodermal dysplasia, these results may have potential clinical significance. The eyes open-eyes closed cycle may involve cycling levels of EGF receptor; since the gene for this receptor shows homology with an oncogene, this system may be useful in studies on genetic control of oncogene function.<\/jats:p>","DOI":"10.1242\/dev.108.2.349","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:40:22Z","timestamp":1619397622000},"page":"349-355","source":"Crossref","is-referenced-by-count":9,"title":["Effect of the X-linked gene <i>Tabby<\/i> (<i>Ta<\/i>) on eyelid opening and incisor eruption in neonatal mice is opposite to that of epidermal growth factor"],"prefix":"10.1242","volume":"108","author":[{"given":"Joachim","family":"Kapalanga","sequence":"first","affiliation":[{"name":"University of Guelph School of Human Biology , , Guelph, Ontario, Canada NIG 2W1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan R.","family":"Blecher","sequence":"additional","affiliation":[{"name":"University of Guelph School of Human Biology , , Guelph, Ontario, Canada NIG 2W1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1990,2,1]]},"reference":[{"key":"2023050311350516800_DEVELOP_108_2_349C1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/0012-1606(84)90007-1","article-title":"The ontogeny of epidermal growth factor receptors during mouse development","volume":"103","author":"Adamson","year":"1984","journal-title":"Devi Biol."},{"key":"2023050311350516800_DEVELOP_108_2_349C2","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/0012-1606(82)90392-X","article-title":"Down regulation of epidermal growth factor receptors in mouse embryos","volume":"90","author":"Adamson","year":"1982","journal-title":"Devi Biol."},{"key":"2023050311350516800_DEVELOP_108_2_349C3","first-page":"17A","article-title":"Possible homology of ectodermal dysplasia and Tabby, and possible role of EGF","volume":"202","author":"Blecher","year":"1982","journal-title":"Anat. Rec."},{"key":"2023050311350516800_DEVELOP_108_2_349C4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/ar.1092070104","article-title":"Pleotropic effect of tabby gene on epidermal growth factorcontaining ceils of mouse submandibular gland","volume":"207","author":"Blecher","year":"1983","journal-title":"Anat. Rec."},{"key":"2023050311350516800_DEVELOP_108_2_349C5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/BF01002997","article-title":"Histochemical studies on genetical control of hormonal enzyme inducibility in the mouse III. \u03b2-Glucuronidase distribution pattern of epididymis in different genotypes","volume":"11","author":"Blecher","year":"1979","journal-title":"Histochem. J."},{"key":"2023050311350516800_DEVELOP_108_2_349C6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0304-4165(74)90052-X","article-title":"The biological assay of epidermal growth factor in neonatal mice","volume":"354","author":"Blosse","year":"1974","journal-title":"Biochim. biophys. Acta."},{"key":"2023050311350516800_DEVELOP_108_2_349C7","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1210\/endo-95-3-776","article-title":"Epidermal growth factor: Effects of androgens and adrenergic agents","volume":"95","author":"Bynny","year":"1974","journal-title":"Endocrinology"},{"key":"2023050311350516800_DEVELOP_108_2_349C8","doi-asserted-by":"publisher","first-page":"8374","DOI":"10.1073\/pnas.82.24.8374","article-title":"Epidermal growth factor regulates the expression of its own receptor","volume":"82","author":"Clark","year":"1985","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"2023050311350516800_DEVELOP_108_2_349C9","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1016\/S0021-9258(19)83739-0","article-title":"Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal","volume":"237","author":"Cohen","year":"1962","journal-title":"J. biol. Chem."},{"key":"2023050311350516800_DEVELOP_108_2_349C10","first-page":"1105","article-title":"Epidermal growth factor-induced stimulation of epidermal growth factor receptor synthesis in human cytotrophoblasts and A431 carcinoma cells","volume":"48","author":"Depalo","year":"1988","journal-title":"Cancer Res."},{"key":"2023050311350516800_DEVELOP_108_2_349C11","first-page":"574","article-title":"A method for numbering laboratory animals using the binary number system","volume":"18","author":"Dubin","year":"1968","journal-title":"Lab. Anim. Care"},{"key":"2023050311350516800_DEVELOP_108_2_349C12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1071\/BI9590312","article-title":"The development and growth of vibrissae in the house mouse with particular reference to the time of action of the Tabby (Ta) and Ragged genes","volume":"12","author":"Dun","year":"1959","journal-title":"Aust. J. biol. Sci."},{"key":"2023050311350516800_DEVELOP_108_2_349C13","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1083\/jcb.98.6.2148","article-title":"Receptor-mediated endocytosis of EGF by hepatocytes in perfused rat liver: Ligand and receptor dynamics","volume":"98","author":"Dunn","year":"1984","journal-title":"J. Cell. Biol."},{"key":"2023050311350516800_DEVELOP_108_2_349C14","doi-asserted-by":"publisher","first-page":"4777","DOI":"10.1016\/S0021-9258(19)89171-8","article-title":"Epidermal growth factor stimulates EGF-receptor synthesis","volume":"261","author":"Earp","year":"1986","journal-title":"J. biol. Chem."},{"key":"2023050311350516800_DEVELOP_108_2_349C15","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/169664b0","article-title":"A totally sex-linked gene in the house mouse","volume":"169","author":"Falconer","year":"1952","journal-title":"Nature, Lond."},{"key":"2023050311350516800_DEVELOP_108_2_349C16","first-page":"210","article-title":"Total sex-linkage in the house mouse. Z","volume":"85","author":"Falconer","year":"1953","journal-title":"indukt. Abstammungs-Vererbungsl."},{"key":"2023050311350516800_DEVELOP_108_2_349C17","volume-title":"Design and Analysis of Experiments in Animal and Medical Sciences.","author":"Gill","year":"1978"},{"key":"2023050311350516800_DEVELOP_108_2_349C18","volume-title":"The Genetics of the Mouse.","author":"Gruneberg","year":"1943"},{"key":"2023050311350516800_DEVELOP_108_2_349C19","first-page":"145","article-title":"The molars of the tabby mouse, and a test of the\u2019single active X-chromosome\u2019 hypothesis","volume":"22","author":"Gruneberg","year":"1966","journal-title":"J. Embryol. exp. Morph."},{"key":"2023050311350516800_DEVELOP_108_2_349C20","first-page":"1","article-title":"The glandular aspects of the tabby syndrome in the mouse","volume":"25","author":"Gruneberg","year":"1971","journal-title":"J. Embryol. exp. Morph."},{"key":"2023050311350516800_DEVELOP_108_2_349C21","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0092-8674(84)90006-0","article-title":"Kinetics of transit of transferrin and EGF through clathrin-coated membranes","volume":"39","author":"Hannover","year":"1984","journal-title":"Cell"},{"key":"2023050311350516800_DEVELOP_108_2_349C22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/BF00318505","article-title":"Eyelid growth and fusion in fetal mice. A scanning electron microscope study","volume":"164","author":"Harris","year":"1982","journal-title":"Anat. Embryol."},{"key":"2023050311350516800_DEVELOP_108_2_349C23","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0003-9969(82)90162-5","article-title":"Reverse hormonedependent sex difference in molar tooth mass in pubertal mice","volume":"27","author":"Heller","year":"1982","journal-title":"Arch, oral Biol."},{"key":"2023050311350516800_DEVELOP_108_2_349C24","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1203\/00006450-198605000-00017","article-title":"Treatment of the neonatal rat with epidermal growth factor: Differences in time and organ response","volume":"20","author":"Hoath","year":"1986","journal-title":"Pediat. Res."},{"key":"2023050311350516800_DEVELOP_108_2_349C25","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1016\/0024-3205(83)90364-8","article-title":"Differential hormonal response of epidermal growth factor concentration in the developing mouse: Synergism of triidothyromine and dexamethasone in epidermal maturation","volume":"32","author":"Hoath","year":"1983","journal-title":"Life Sci."},{"key":"2023050311350516800_DEVELOP_108_2_349C26","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/oxfordjournals.jhered.a107584","article-title":"Some observations on the skin and hair of tabby mice","volume":"58","author":"Kindred","year":"1967","journal-title":"J. Hered."},{"key":"2023050311350516800_DEVELOP_108_2_349C27","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3109\/01485018108987357","article-title":"Histochemical studied on genetical control of hormonal enzyme inducibility in the mouse. IV. Cellular localization of androgen sensitive non-specific esterase in the epididymis","volume":"6","author":"Kirkeby","year":"1981","journal-title":"Arch. Androl."},{"key":"2023050311350516800_DEVELOP_108_2_349C28","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.1016\/S0021-9258(17)35635-1","article-title":"EGF stimulates the synthesis of its own receptor in a human breast cancer cell line","volume":"261","author":"Kudlow","year":"1986","journal-title":"J. biol. Chem."},{"key":"2023050311350516800_DEVELOP_108_2_349C29","first-page":"679","article-title":"Toe clipping procedure for individual identification of rodents","volume":"29","author":"Kumar","year":"1979","journal-title":"Lab. Anim. Sci."},{"key":"2023050311350516800_DEVELOP_108_2_349C30","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/S0003-2697(79)80153-0","article-title":"Radio receptor assay for epidermal growth factor","volume":"93","author":"Ladda","year":"1979","journal-title":"Analyt. Biochem."},{"key":"2023050311350516800_DEVELOP_108_2_349C31","first-page":"215","article-title":"The periodontal ligament and physiological tooth movements","volume-title":"The Periodontal Ligament in Health and Disease","author":"Moxham","year":"1982"},{"key":"2023050311350516800_DEVELOP_108_2_349C32","article-title":"Eruption-A review","volume-title":"The Mechanisms of Tooth Support.","author":"Ness","year":"1967"},{"key":"2023050311350516800_DEVELOP_108_2_349C33","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/ar.1091680109","article-title":"The perinatal development of the mouse eye","volume":"168","author":"Pei","year":"1970","journal-title":"Anat. Rec."},{"key":"2023050311350516800_DEVELOP_108_2_349C34","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/0012-1606(87)90204-1","article-title":"Onset of endogenous synthesis of epidermal growth factor in neonatal mice","volume":"119","author":"Popuker","year":"1987","journal-title":"Devi Biol."},{"key":"2023050311350516800_DEVELOP_108_2_349C35","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0012-1606(87)90156-4","article-title":"Epidermal growth factor-induced precocious incisor eruption is associated with decreased tooth size","volume":"121","author":"Rhodes","year":"1987","journal-title":"Devi Biol."},{"key":"2023050311350516800_DEVELOP_108_2_349C36","volume-title":"The Mouse: Its Reproduction and Development. Minneapolis: Burgess Publishing Company","author":"Rugh","year":"1968"},{"key":"2023050311350516800_DEVELOP_108_2_349C37","first-page":"243","article-title":"Demonstration of a considerable amount of mouse epidermal growth factor in aqueous humor","volume":"17","author":"Shinoda","year":"1988","journal-title":"Biochem. Int."},{"key":"2023050311350516800_DEVELOP_108_2_349C38","first-page":"181","article-title":"Aspects of the tabby-crinkled-downless syndrome. I. The development of tabby teeth","volume":"22","author":"Sofaer","year":"1969","journal-title":"J. Embryol. exp. Morph."},{"key":"2023050311350516800_DEVELOP_108_2_349C39","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/313745a0","article-title":"Autocrine growth factors and cancer","volume":"313","author":"Sporn","year":"1985","journal-title":"Nature, Lond. Lond"},{"key":"2023050311350516800_DEVELOP_108_2_349C40","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0003-9969(80)90153-3","article-title":"Histomorphological effects of epidermal growth factor on skin and oral mucosa in neonatal mice","volume":"25","author":"Steidler","year":"1980","journal-title":"Arch. Oral. Biol."},{"key":"2023050311350516800_DEVELOP_108_2_349C41","volume-title":"The House Mouse.","author":"Theiler","year":"1972"},{"key":"2023050311350516800_DEVELOP_108_2_349C42","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/0012-1606(87)90506-9","article-title":"The effect of epidermal growth factor on neonatal incisor differentiation in the mouse","volume":"124","author":"Topham","year":"1987","journal-title":"Devi Biol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/108\/2\/349\/2803640\/develop_108_2_349.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/108\/2\/349\/2803640\/develop_108_2_349.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T11:44:06Z","timestamp":1683114246000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/108\/2\/349\/36383\/Effect-of-the-X-linked-gene-Tabby-Ta-on-eyelid"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2,1]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,2,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.108.2.349","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2,1]]}}}