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Labelling was also seen over E3 primordium of the trigeminal ganglion (V) and in the placodal thickening of the petrosal (IX) and nodose (X) ganglionic primordia. In the E5 embryo, all cranial sensory ganglia (V, VII, VIII, IX, X) expressed NGF-R mRNA although at varying levels with higher levels in the ganglia of the Vth, IXth and Xth cranial nerves than in ganglia of the VIIth and the VIIIth nerves. Within ganglia of the Vth, IXth and Xth cranial nerves, levels of NGF-R mRNA were higher in regions containing placode-derived neurons, than in regions with neural-crest-derived neurons. The placode-derived nodose ganglion (X) expressed NGF-R mRNA at all stages of development. In the E15 embryo and later in development, two thirds of the large neuron-like cells expressed high levels of NGF-R mRNA. Our results show that expression of NGF-R mRNA, in peripheral neurons, is not restricted to cells of neural crest origin. We also show a transient expression of NGF-R mRNA early in development in a wide range of non-neuronal differentiating cells. The high level of NGF-R mRNA in early differentiating tissues suggest that the NGF-R plays a wider role during development than previously anticipated.<\/jats:p>","DOI":"10.1242\/dev.108.4.693","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:48:17Z","timestamp":1619398097000},"page":"693-704","source":"Crossref","is-referenced-by-count":56,"title":["Expression of nerve growth factor receptor mRNA during early development of the chicken embryo: emphasis on cranial ganglia"],"prefix":"10.1242","volume":"108","author":[{"given":"Finn","family":"Hallb\u00f6\u00f6k","sequence":"first","affiliation":[{"name":"1 Department of Medical Chemistry II, Laboratory of Molecular Neurobiology, Karolinska Institute, Box 60400, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Ayer-Leli\u00e8vre","sequence":"additional","affiliation":[{"name":"2 Department of Histology and Neurobiology, Karolinska Institute, Box 60400, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted","family":"Ebendal","sequence":"additional","affiliation":[{"name":"Uppsala University 3 Department of Developmental Biology, Biomedical Center , , Box 587, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e4kan","family":"Persson","sequence":"additional","affiliation":[{"name":"1 Department of Medical Chemistry II, Laboratory of Molecular Neurobiology, Karolinska Institute, Box 60400, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1990,4,1]]},"reference":[{"key":"2023050311413511100_DEVELOP_108_4_693C1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0012-1606(82)90349-9","article-title":"The early development of cranial sensory ganglia and the potentialities of their component cells studied in Quail-Chick chimeras","volume":"94","author":"Ayer-Leli\u00e8vre","year":"1982","journal-title":"Devl Biol"},{"key":"2023050311413511100_DEVELOP_108_4_693C2","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1073\/pnas.70.9.2519","article-title":"Binding of nerve growth factor in superior cervical ganglia","volume":"79","author":"Banerjee","year":"1973","journal-title":"Proc. natn. 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