{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:56:25Z","timestamp":1760784985865},"reference-count":24,"publisher":"The Company of Biologists","issue":"Supplement","license":[{"start":{"date-parts":[[1990,4,1]],"date-time":"1990-04-01T00:00:00Z","timestamp":638928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Genetic imprinting in mice results in functional differences in the oocyte and spermatocyte genomes, as evidenced by both genetic and pronuclear transfer experiments. To gain insights into the molecular mechansims involved in the imprinting process, researchers have studied methylation phenotypes and expression of hemizygous transgenes associated with parental origin. In this report, we describe a transgenic mouse lineage in which expression of both the transgene and an endogenous gene at the insertion site are determined by the parent of origin. The mutation caused by transgene insertion shows variable expressivity and incomplete penetrance in addition to a modified dominant pattern of inheritance.<\/jats:p>","DOI":"10.1242\/dev.108.supplement.73","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:41:50Z","timestamp":1619397710000},"page":"73-79","source":"Crossref","is-referenced-by-count":21,"title":["A transgene insertional mutation at an imprinted locus in the mouse genome"],"prefix":"10.1242","volume":"108","author":[{"given":"Julie A.","family":"DeLoia","sequence":"first","affiliation":[{"name":"The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davor","family":"Solter","sequence":"additional","affiliation":[{"name":"The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1990,4,1]]},"reference":[{"key":"2024022601470011500_DEVELOP_108_S_73C1","first-page":"48","article-title":"Genetic Imprinting Map","volume":"84","author":"Beechey","year":"1989","journal-title":"Mouse News Letter"},{"key":"2024022601470011500_DEVELOP_108_S_73C2","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/0896-6273(89)90066-4","article-title":"Retinoids, homeobox genes and limb morphogenesis","volume":"2","author":"Brockes","year":"1989","journal-title":"Neuron"},{"issue":"Supplement","key":"2024022601470011500_DEVELOP_108_S_73C3","first-page":"137","article-title":"Parental origin effects in mice","volume":"97","author":"Cattanach","year":"1986","journal-title":"J. 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