{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:53:53Z","timestamp":1791064433364,"version":"4.1.0"},"reference-count":36,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[1990,8,1]],"date-time":"1990-08-01T00:00:00Z","timestamp":649468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have identified a glycoprotein (BEN) of 95 \u2013100 \u00d7103Mr using a monoclonal antibody. This protein is transiently expressed at the cell surface of the peripherally projecting neurons, i.e. motoneurons of the spinal cord and cranial nuclei, sensory neurons of the dorsal root and cranial sensory ganglia and sympathetic, parasympathetic and enteric neurons. In vitro cultures of dorsal root and sympathetic ganglia have shown that BEN is expressed on neurons but not on glial cells. On motor and sensory neurons, BEN first appears at the level of the cell body just after withdrawal from the cell cycle. Soon afterwards, expression of the antigen extends to the elongating axon. After a few days, BEN is no longer expressed by the motor and sensory neurons, disappearing first from the cell body and then progressively from the fibres. The loss of expression is concomitant with the onset of intense proliferation of satellite and Schwann cells. This modulated expression within the nervous sytem is unlike that of any surface glycoprotein so far described in vertebrates. Preliminary biochemical analysis indicates that, although it bears the adhesion-associated epitope HNK-1, BEN does not share characteristics with any previously described axonal glycoprotein. Consequently, we speculate that this glycoprotein might be a novel molecule implicated in selective adhesion phenomena, such as axonal fasciculation.<\/jats:p>","DOI":"10.1242\/dev.109.4.743","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T09:17:13Z","timestamp":1619255833000},"page":"743-752","source":"Crossref","is-referenced-by-count":89,"title":["A widely distributed antigen developmentally regulated in the nervous system"],"prefix":"10.1242","volume":"109","author":[{"given":"Olivier","family":"Pourqui\u00e9","sequence":"first","affiliation":[{"name":"Institut d\u2019embryologie cellulaire et mol\u00e9culaire du CNRS et du Coll\u00e8ge de France , 49 bis avenue de la Belle Gabnelle, 94 736 Nogent sur Marne, Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Coltey","sequence":"additional","affiliation":[{"name":"Institut d\u2019embryologie cellulaire et mol\u00e9culaire du CNRS et du Coll\u00e8ge de France , 49 bis avenue de la Belle Gabnelle, 94 736 Nogent sur Marne, Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-L\u00e9on","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institut d\u2019embryologie cellulaire et mol\u00e9culaire du CNRS et du Coll\u00e8ge de France , 49 bis avenue de la Belle Gabnelle, 94 736 Nogent sur Marne, Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Le Douarin","sequence":"additional","affiliation":[{"name":"Institut d\u2019embryologie cellulaire et mol\u00e9culaire du CNRS et du Coll\u00e8ge de France , 49 bis avenue de la Belle Gabnelle, 94 736 Nogent sur Marne, Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1990,8,1]]},"reference":[{"key":"2023050311021649900_DEVELOP_109_4_743C1","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.4049\/jimmunol.127.3.1024","article-title":"A differentiation antigen of human NK cells identified by a monoclonal antibody (HNK-1)","volume":"127","author":"Abo","year":"1981","journal-title":"J. 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