{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:18:59Z","timestamp":1789773539593,"version":"4.0.1"},"reference-count":50,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1991,1,9]],"date-time":"1991-01-09T00:00:00Z","timestamp":663379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,1,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The expression of three different members of the gap junction multigene family, ax (Cx43), ft (Cx32), and p2 (Cx26), was analysed in the rat implantation chamber (a structural unit containing fetal, extraembryonic and maternal components within the pregnant uterus) during mid-and late stages of gestation as well as in the delivering, post-partum and non-pregnant uterus. A differential, spatiotemporal and cell-type-specific regulation of gap junctional coexpression was observed for Pi and p2 \u2022 \u2033 a \u2033 epithelia examined (visceral, luminal and glandular), as well as for a, and ft in decidual cells and keratinocytes of the fetal epidermis, aj antigen was detected in the mesometrial stroma, mesometrial myometrium, connective tissue, mesothelia of the amnion and visceral yolk sac and in the allantoic mesodermal layer throughout gestation. In addition, expression of at in the placental basal zone and trophoblast giant cells coincided with the differentiation of these cells, fi expression was observed prominently in the chorionic villi of the placental labyrinth. The presence of Pi and P2 in the visceral epithelium (visceral yolk sac=the primary route for embryonic nourishment prior to the formation of the chorioallantoic placenta) and p2 in the chorionic villi (placental barrier=the major fetomaternai exchange route) suggests that gap junctions have an important role in fetomaternai communication.<\/jats:p>","DOI":"10.1242\/dev.113.1.165","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T18:25:04Z","timestamp":1619202304000},"page":"135-181","source":"Crossref","is-referenced-by-count":59,"title":["Spatiotemporal expression of three gap junction gene products involved in fetomaternai communication during rat pregnancy"],"prefix":"10.1242","volume":"113","author":[{"given":"Boris","family":"Risek","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norton B.","family":"Gilula","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1991,1,9]]},"reference":[{"key":"2024022604120505600_DEVELOP_113_1_165C1","first-page":"167","article-title":"The connexins, a family of related gap junction proteins","volume-title":"In Gap Junctions","author":"Beyer","year":"1988"},{"key":"2024022604120505600_DEVELOP_113_1_165C2","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1083\/jcb.105.6.2621","article-title":"Molecular cloning of cDNA for connexin43, a gap junction protein from rat heart","volume":"105","author":"Beyer","year":"1987","journal-title":"J. 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