{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:03:16Z","timestamp":1791133396907,"version":"4.1.0"},"reference-count":43,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[1991,11,1]],"date-time":"1991-11-01T00:00:00Z","timestamp":688953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>A genetically defined element of the fruitless (fru) locus in Drosophila melanogaster regulates the development of a male-specific muscle spanning the fifth abdominal segment in adult males, the \u2018muscle of Lawrence\u2019 (MOL). The region is defined by two cytological deletions, each with a breakpoint that co-maps with previously described mutant courtship phenotypes at cytogenetic interval 91B on the third chromosome. Flies that carry both of these deletions are viable, and males express abnormalities of courtship similar to those caused by the fru inversion breakpoint at 91B. In addition, these double-deletion males show the complete absence of the MOL, suggesting that they have little or no gene expression of a postulated MOL determinant; the musculature in the fifth abdominal segment of these mutants to indistinguishable from that of a normal female. Other mutant combinations that produce fruitless courtship phenotypes -including deletion and inversion breakpoints, and a marked transposon inserted at 91B -produce intermediate forms of the MOL. A new genetic variant, induced by imprecise excision of the marked transposon, is homozygous lethal and disrupts fru functions related to courtship and the MOL. The MOL is shown to be dispensable for fertility and is therefore not the causative factor of fru-induced behavioral sterility. These genetic variants and their phenotypic results are discussed with regard to a model for the organization of the fru locus.<\/jats:p>","DOI":"10.1242\/dev.113.3.879","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T18:24:09Z","timestamp":1619202249000},"page":"879-890","source":"Crossref","is-referenced-by-count":91,"title":["Elements of the <i>fruitless<\/i> locus regulate development of the muscle of Lawrence, a male-specific structure in the abdomen of <i>Drosophila melanogaster<\/i> adults"],"prefix":"10.1242","volume":"113","author":[{"given":"Donald A.","family":"Gailey","sequence":"first","affiliation":[{"name":"Brand\u00e9is University, Waltham 1 Department of Biology , , Massachusetts 02254, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of California at San Diego 2 Department of Biology , , La Jolla, California 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Hall","sequence":"additional","affiliation":[{"name":"Brand\u00e9is University, Waltham 1 Department of Biology , , Massachusetts 02254, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1991,11,1]]},"reference":[{"key":"2023050312422699400_DEVELOP_113_3_879C1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/340521a0","article-title":"Sex in flies: the splice of life","volume":"340","author":"Baker","year":"1989","journal-title":"Nature"},{"key":"2023050312422699400_DEVELOP_113_3_879C2","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1242\/dev.110.3.791","article-title":"The embryonic development of larval muscles in Drosophila","volume":"110","author":"Bate","year":"1990","journal-title":"Development"},{"key":"2023050312422699400_DEVELOP_113_3_879C3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/289079a0","article-title":"Defect in cyclic-AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster","volume":"289","author":"Byers","year":"1981","journal-title":"Nature"},{"key":"2023050312422699400_DEVELOP_113_3_879C4","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3109\/01677068609106856","article-title":"The pattern of early neuronal differentiation in Drosophila melanogaster","volume":"3","author":"Canal","year":"1986","journal-title":"J. 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