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Results indicated notable PCP defects, including mis-oriented hair cell stereociliary bundles, in Bbs8 and Ift20 single mutants that are more severe than in other cilia gene knockouts. In addition, deletion of either Bbs8 or Ift20 results in disruptions in asymmetric accumulation of the core PCP molecule Vangl2 in cochlear cells, suggesting a role for Bbs8 and\/or Ift20, possibly upstream of core PCP asymmetry. Consistent with this, co-immunoprecipitation experiments indicate direct interactions of Bbs8 and Ift20 with Vangl2. We observed localization of Bbs and Ift proteins to filamentous actin as well as microtubules. This could implicate these molecules in selective trafficking of membrane proteins upstream of cytoskeletal reorganization, and identifies new roles for cilia-related proteins in cochlear PCP.<\/jats:p>","DOI":"10.1242\/dev.113696","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T12:36:17Z","timestamp":1421757377000},"page":"555-566","source":"Crossref","is-referenced-by-count":77,"title":["Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea"],"prefix":"10.1242","volume":"142","author":[{"given":"Helen L.","family":"May-Simera","sequence":"first","affiliation":[{"name":"Section on Developmental Neuroscience, Laboratory of Cochlear Development, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald S.","family":"Petralia","sequence":"additional","affiliation":[{"name":"Advanced Imaging 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