{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:10:19Z","timestamp":1791022219251,"version":"4.1.0"},"reference-count":35,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[1992,10,1]],"date-time":"1992-10-01T00:00:00Z","timestamp":717897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>A discovery that the protooncogene encoding the receptor tyrosine kinase, c-kit, is allelic with the Dominant white spotting (W) locus establishes that c-kit plays a functional role in the development of three cell lineages, melanocyte, germ cell, and hematopoietic cell which are defective in W mutant mice. Recent analyses of c-kit expression in various tissues of mouse, however, have demonstrated that c-kit is expressed in more diverse tissues which are phenotypically normal in W mutant mice. Thus, whether or not c-kit expressed outside the three known cell lineages plays a functional role is one of the important questions needing answering in order to fully elucidate the role of c-kit in the development of the mouse. Here, we report that some of the cells in smooth muscle layers of developing intestine express c-kit. Blockade of its function for a few days postnatally by an antagonistic anti-c-kit monoclonal antibody (mAb) results in a severe anomaly of gut movement, which in BALB\/c mice produces a lethal paralytic ileus. Physiological analysis indicates that the mechanisms required for the autonomic pacing of contraction in an isolated gut segment are defective in the anti-c-kit mAb-treated mice, W\/Wvmice and even W\/+ mice. These findings suggest that c-kit plays a crucial role in the development of a component of the pacemaker system that is required for the generation of autonomic gut motility.<\/jats:p>","DOI":"10.1242\/dev.116.2.369","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T01:08:38Z","timestamp":1619399318000},"page":"369-375","source":"Crossref","is-referenced-by-count":565,"title":["Requirement of <i>c-kit<\/i> for development of intestinal pacemaker system"],"prefix":"10.1242","volume":"116","author":[{"given":"Hitomi","family":"Maeda","sequence":"first","affiliation":[{"name":"Kumamoto University School of Medicine 1 Institute of Molecular Embryology and Genetics , , 2-2-1 Honjo, Kumamoto 860, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Kumamoto University School of Medicine 2 Department of Pharmacology , , 2-2-1 Honjo, Kumamoto 860, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Kumamoto University School of Medicine 1 Institute of Molecular Embryology and Genetics , , 2-2-1 Honjo, Kumamoto 860, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Kumamoto University School of Medicine 3 Department of Anatomy , , 2-2-1 Honjo, Kumamoto 860, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Nagoya University, School of Medicine, Nagoya, Japan 4 Department of Anatomy ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhide","family":"Nishi","sequence":"additional","affiliation":[{"name":"Kumamoto University School of Medicine 2 Department of Pharmacology , , 2-2-1 Honjo, Kumamoto 860, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Ichi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Kumamoto University School of Medicine 1 Institute of Molecular Embryology and Genetics , , 2-2-1 Honjo, Kumamoto 860, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1992,10,1]]},"reference":[{"key":"2024121722202361400_DEVELOP_116_2_369C1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/335088a0","article-title":"The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus","volume":"335","author":"Chabot","year":"1988","journal-title":"Nature"},{"key":"2024121722202361400_DEVELOP_116_2_369C2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0092-8674(90)90298-S","article-title":"Mast cell growth factor maps near the Steel locus on mouse chromosome 10 and is deleted in a number of Steel alleles","volume":"63","author":"Copeland","year":"1990","journal-title":"Cell"},{"key":"2024121722202361400_DEVELOP_116_2_369C3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00303144","article-title":"Morphogenesis of the special circular muscle layer and the interstitial cells of Cajal related to the plexus muscularis profundus of mouse intestinal muscle coat","volume":"169","author":"Faussone-Pellegrini","year":"1984","journal-title":"Anat. Embryol"},{"key":"2024121722202361400_DEVELOP_116_2_369C4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/genetics\/97.2.337","article-title":"Analysis of pleiotropism at the dominat white spotting (W) locus of the house mouse: A description of ten new W alleles","volume":"97","author":"Geissler","year":"1981","journal-title":"Genetics"},{"key":"2024121722202361400_DEVELOP_116_2_369C5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(88)90020-7","article-title":"The dominant white spotting (W) locus of the mouse encodes the c-kit protooncogene","volume":"55","author":"Geissler","year":"1988","journal-title":"Cell"},{"key":"2024121722202361400_DEVELOP_116_2_369C6","doi-asserted-by":"crossref","first-page":"8696","DOI":"10.1073\/pnas.88.19.8696","article-title":"Mutation of the KIT (mast\/stem cell growth factor receptor) protooncogene in human piebaldism","volume":"88","author":"Giebel","year":"1991","journal-title":"Proc.Natl.Acad.Sci. USA"},{"key":"2024121722202361400_DEVELOP_116_2_369C7","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/nar\/19.6.1267","article-title":"Exon skipping by mutation of an authentic splice site of c-kit gene in W\/W mouse","volume":"19","author":"Hayashi","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"2024121722202361400_DEVELOP_116_2_369C8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0092-8674(90)90303-V","article-title":"The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus","volume":"63","author":"Huang","year":"1990","journal-title":"Cell"},{"key":"2024121722202361400_DEVELOP_116_2_369C9","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1002\/j.1460-2075.1991.tb07782.x","article-title":"Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development","volume":"10","author":"Keshet","year":"1991","journal-title":"EMBO J"},{"key":"2024121722202361400_DEVELOP_116_2_369C10","first-page":"103","article-title":"The structure of the autonomic end apparatus in the guinea-pig small intestine and the problem of the interstitial cells of Cajal","volume":"38","author":"Kobayashi","year":"1990","journal-title":"Acta. Med. Biol"},{"key":"2024121722202361400_DEVELOP_116_2_369C11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/oxfordjournals.jhered.a107457","article-title":"Association of megacolon with two recessive spotting genes in the mouse","volume":"57","author":"Lane","year":"1966","journal-title":"J. Hered"},{"key":"2024121722202361400_DEVELOP_116_2_369C12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/oxfordjournals.jhered.a109980","article-title":"Association of megacolon with a new dominant spotting gene (Dom) in the mouse","volume":"75","author":"Lane","year":"1984","journal-title":"J. Hered"},{"key":"2024121722202361400_DEVELOP_116_2_369C13","first-page":"103","article-title":"Spontaneous electrical activity of interstitial cell of Cajal isolated from canine proximal colon","volume":"86","author":"Langton","year":"1990","journal-title":"Proc.Natl.Acad.Sci. USA"},{"key":"2024121722202361400_DEVELOP_116_2_369C14","first-page":"397","article-title":"Le reactif au tetraoxyde de osmiumiodure du zinc","volume":"70","author":"Maillet","year":"1963","journal-title":"Z. Mikrosk. Anat. Forsch"},{"key":"2024121722202361400_DEVELOP_116_2_369C15","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1242\/dev.110.4.1057","article-title":"Gonadal expression of c-kit encoded at the W locus of the mouse","volume":"110","author":"Manova","year":"1990","journal-title":"Development"},{"key":"2024121722202361400_DEVELOP_116_2_369C16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/347667a0","article-title":"Embryonic expression of a haematopoietic growth factor encoded by Sl locus and the ligand for c-kit","volume":"347","author":"Matsui","year":"1990","journal-title":"Nature"},{"key":"2024121722202361400_DEVELOP_116_2_369C17","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1242\/dev.113.4.1207","article-title":"Contiguous patterns of c-kit and steel expression: analysis of mutation at the W and Sl loci","volume":"113","author":"Motro","year":"1991","journal-title":"Development"},{"key":"2024121722202361400_DEVELOP_116_2_369C18","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1002\/j.1460-2075.1991.tb07744.x","article-title":"In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development","volume":"10","author":"Nishikawa","year":"1991","journal-title":"EMBO J"},{"key":"2024121722202361400_DEVELOP_116_2_369C19","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1002\/j.1460-2075.1990.tb08305.x","article-title":"Molecular bases of dominant negative and loss of function mutation at the murine c-kit\/white spotting locus: W37, Wv, W41 and W","volume":"9","author":"Nocka","year":"1990","journal-title":"EMBO J"},{"key":"2024121722202361400_DEVELOP_116_2_369C20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1084\/jem.174.1.63","article-title":"Expression and function of c-kit in hemopoietic progenitor cells","volume":"174","author":"Ogawa","year":"1991","journal-title":"J.Exp.Med"},{"key":"2024121722202361400_DEVELOP_116_2_369C21","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1242\/dev.109.4.911","article-title":"Developmental expression of c-kit, a proto-oncogene encoded by the W locus","volume":"109","author":"Orr-Urtreger","year":"1990","journal-title":"Development"},{"key":"2024121722202361400_DEVELOP_116_2_369C22","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1182\/blood.V78.6.1403.1403","article-title":"Isolation of c-kit receptor expressing cells from bone marrow, peripheral blood, and fetal liver: Functional properties and composite antigenic profile","volume":"78","author":"Papayannopoulou","year":"1991","journal-title":"Blood"},{"key":"2024121722202361400_DEVELOP_116_2_369C23","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/j.1460-2075.1988.tb02907.x","article-title":"Primary structure of c-kit : relationship with the CSF-1\/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C-terminus","volume":"7","author":"Qui","year":"1988","journal-title":"EMBO J"},{"key":"2024121722202361400_DEVELOP_116_2_369C24","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1101\/gad.4.3.390","article-title":"W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit transmembrane receptor","volume":"4","author":"Reith","year":"1990","journal-title":"Genes Dev"},{"key":"2024121722202361400_DEVELOP_116_2_369C25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0065-2660(08)60549-0","article-title":"Hereditary anemias of the mouse: a review for geneticists","volume":"20","author":"Russell","year":"1979","journal-title":"Adv. Genetics"},{"key":"2024121722202361400_DEVELOP_116_2_369C26","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/283662a0","article-title":"Spontaneous stomach ulcer in genetically mast-cell depleted W\/Wv mice","volume":"283","author":"Shimada","year":"1980","journal-title":"Nature"},{"key":"2024121722202361400_DEVELOP_116_2_369C27","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/978-1-4612-6164-3_10","article-title":"White-spotting, patch and rump-white","volume-title":"In The coat colors of mice: A model for gene action and interaction","author":"Silvers","year":"1979"},{"key":"2024121722202361400_DEVELOP_116_2_369C28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/eji.1830090410","article-title":"Mac-1: a macrophage differentiation antigen indentified by monoclonal antibody","volume":"9","author":"Springer","year":"1979","journal-title":"Eur.J.Immunol"},{"key":"2024121722202361400_DEVELOP_116_2_369C29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1126\/science.1688471","article-title":"The dominant W42spotting phenotype results from a missense mutation in the c-kit kinase receptor","volume":"247","author":"Tan","year":"1990","journal-title":"Science"},{"key":"2024121722202361400_DEVELOP_116_2_369C30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-68417-3_1","article-title":"Interstitial cells of Cajal: intestinal pacemaker cells?","volume":"71","author":"Thuneberg","year":"1982","journal-title":"Adv. Anat. Embryol. Cell. Biol"},{"key":"2024121722202361400_DEVELOP_116_2_369C31","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1002\/j.1460-2075.1987.tb02655.x","article-title":"Human proto-oncogene c-kit : a new cell surface receptor tyrosine kinase for an unidentified ligand","volume":"6","author":"Yarden","year":"1987","journal-title":"EMBO J"},{"key":"2024121722202361400_DEVELOP_116_2_369C32","first-page":"3806","article-title":"Necessity of bile for and lack of inhibitory effect of retinoid on development of forestomach papillomas in nontreated mutant mice of the W\/Wv genotype","volume":"42","author":"Yokoyama","year":"1982","journal-title":"Cancer Res"},{"key":"2024121722202361400_DEVELOP_116_2_369C33","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1242\/dev.113.2.689","article-title":"Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function","volume":"113","author":"Yoshinaga","year":"1991","journal-title":"Development"},{"key":"2024121722202361400_DEVELOP_116_2_369C34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/BF02890225","article-title":"Biologic characterization of human bone tumors","volume":"53","author":"Voller","year":"1987","journal-title":"Virchow Arch. B"},{"key":"2024121722202361400_DEVELOP_116_2_369C35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0092-8674(90)90302-U","article-title":"Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor","volume":"63","author":"Zsebo","year":"1990","journal-title":"Cell"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/116\/2\/369\/3588896\/develop_116_2_369.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/116\/2\/369\/3588896\/develop_116_2_369.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T22:20:39Z","timestamp":1734474039000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/116\/2\/369\/37595\/Requirement-of-c-kit-for-development-of-intestinal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10,1]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,10,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.116.2.369","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10,1]]}}}