{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:45:57Z","timestamp":1771011957571,"version":"3.50.1"},"reference-count":35,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[1992,10,1]],"date-time":"1992-10-01T00:00:00Z","timestamp":717897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The murine Hox-3.5 gene has been mapped and linked genomically to a position 18 kb 3 of its most 5 locus neighbour, Hox-3.4, on chromosome 15. The sequence of the Hox-3.5 cDNA, together with the position of the gene within the locus, show it to be a paralogue of Hox-2.6, Hox-1.4 and Hox-4.2. The patterns of embryonic expression for the Hox-3.5 gene are examined in terms of three rules, proposed to relate a Hox gene\u2019s expression pattern to its position within the locus. The anterior boundaries of Hox-3.5 expression in the hind-brain and prevertebral column lie anterior to those of Hox-3.4 and all other, more 5-located Hox-3 genes. Within the hindbrain, the Hox-3.5 boundary is seen to lie posterior to that of its paralogue, Hox-2.6, by a distance equal to about the length of one rhombomere. Patterns of Hox-3.5 expression within the oesophagus and spinal cord, but not the testis, are similar to those of other Hox-3 genes, Hox-3.3 and Hox-3.4.<\/jats:p>","DOI":"10.1242\/dev.116.2.497","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T01:09:05Z","timestamp":1619399345000},"page":"497-506","source":"Crossref","is-referenced-by-count":40,"title":["Sequence and embryonic expression of the murine <i>Hox-3<\/i>.<i>5<\/i> gene"],"prefix":"10.1242","volume":"116","author":[{"given":"Ant\u00f3nio M. C.","family":"Geada","sequence":"first","affiliation":[{"name":"University of Manchester 1 Molecular Embryology Laboratory, Department of Cell and Structural Biology, Stopford Building , , Manchester, M13 9PT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Gaunt","sequence":"additional","affiliation":[{"name":"2 Department of Molecular Embryology, IAPGR, Babraham, Cambridge, CB2 4AT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May","family":"Azzawi","sequence":"additional","affiliation":[{"name":"University of Manchester 1 Molecular Embryology Laboratory, Department of Cell and Structural Biology, Stopford Building , , Manchester, M13 9PT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian M.","family":"Shimeld","sequence":"additional","affiliation":[{"name":"University of Manchester 1 Molecular Embryology Laboratory, Department of Cell and Structural Biology, Stopford Building , , Manchester, M13 9PT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Pearce","sequence":"additional","affiliation":[{"name":"2 Department of Molecular Embryology, IAPGR, Babraham, Cambridge, CB2 4AT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul T.","family":"Sharpe","sequence":"additional","affiliation":[{"name":"University of Manchester 1 Molecular Embryology Laboratory, Department of Cell and Structural Biology, Stopford Building , , Manchester, M13 9PT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1992,10,1]]},"reference":[{"key":"2024121722205334800_DEVELOP_116_2_497C1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/j.1460-2075.1988.tb02948.x","article-title":"Primary structure and developmental expression pattern of Hox-3.1, a member of the murine Hox-3 homeobox gene cluster","volume":"7","author":"Breier","year":"1988","journal-title":"EMBO J"},{"key":"2024121722205334800_DEVELOP_116_2_497C2","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1002\/j.1460-2075.1986.tb04585.x","article-title":"Genetic and cytogenic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7","volume":"5","author":"Bucan","year":"1986","journal-title":"EMBO J"},{"key":"2024121722205334800_DEVELOP_116_2_497C3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/350473a0","article-title":"Regionally restricted developmental defects resulting from target disruption of the mouse homeobox gene Hox-1.5","volume":"350","author":"Chisaka","year":"1991","journal-title":"Nature"},{"key":"2024121722205334800_DEVELOP_116_2_497C4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/355516a0","article-title":"Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6","volume":"355","author":"Chisaka","year":"1992","journal-title":"Nature"},{"key":"2024121722205334800_DEVELOP_116_2_497C5","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/0888-7543(90)90185-W","article-title":"An update of mouse and human HOX gene nomeclature","volume":"7","author":"Duboule","year":"1990","journal-title":"Genomics"},{"key":"2024121722205334800_DEVELOP_116_2_497C6","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/j.1460-2075.1989.tb03534.x","article-title":"The structural and functional organisation of the murine Hox gene family resembles that of the Drosophila homeotic genes","volume":"8","author":"Duboule","year":"1989","journal-title":"EMBO J"},{"key":"2024121722205334800_DEVELOP_116_2_497C7","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1073\/pnas.85.13.4760","article-title":"Hox-5.1 defines a homeobox-containing gene locus on the mouse chromosome 2","volume":"85","author":"Featherstone","year":"1988","journal-title":"Proc. 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