{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:06:45Z","timestamp":1789376805720,"version":"build-2803163510"},"reference-count":37,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[1992,12,1]],"date-time":"1992-12-01T00:00:00Z","timestamp":723168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We found that E-cadherin (uvomorulin) is transiently expressed in restricted regions of the metencephalon, mesencephalon and diencephalon of mouse embryonic brain. This expression first occurred in parts of the mes-encephalon and diencephalon at around E9.5, and subsequently extended to the primordia of cerebellum, the dorsal midline of mesencephalon and some other regions of the embryonic brain. These E-cadherin expressions ceased by E15 except at the dorsal midline. Immuno-histological analyses showed that E-cadherin-positive cells are radially arranged in the neural tube and the E-cadherin-positive regions are sharply demarcated from E-cadherin-negative regions. Axons extending from some of the E-cadherin-positive regions also expressed this molecule. When embryonic brains were dissociated into single cells and cultured as monolayers, E-cadherin-positive cells formed clusters that were seg-regated from E-cadherin-negative cells. E9.5 brain fragments containing metencephalon and mesencephalon were isolated, explanted on Nuclepore filters and cul-tured in the absence or presence of antibodies to E-cad-herin. This antibody treatment removed most of the E-cadherin molecules from the explants and consequently affected their growth pattern. To analyze cellular events induced by the antibody treatment, we stained these explants with an antiserum to En whose distribution was found to overlap in part with that of E-cadherin and found that the pattern of En staining was altered by the anti-E-cadherin antibody treatment. These results suggest that the local and transient expression of E-cad-herin in embryonic brain is involved in regional pattern formation in this organ.<\/jats:p>","DOI":"10.1242\/dev.116.4.1011","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T01:12:49Z","timestamp":1619399569000},"page":"1011-1019","source":"Crossref","is-referenced-by-count":88,"title":["Local and transient expression of E-cadherin involved in mouse embryonic brain morphogenesis"],"prefix":"10.1242","volume":"116","author":[{"given":"Kenji","family":"Shimamura","sequence":"first","affiliation":[{"name":"Kyoto University, Kitashirakawa Department of Biophysics, Faculty of Science , , Sakyo-ku, Kyoto 606, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Takeichi","sequence":"additional","affiliation":[{"name":"Kyoto University, Kitashirakawa Department of Biophysics, Faculty of Science , , Sakyo-ku, Kyoto 606, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1992,12,1]]},"reference":[{"key":"2024121722362211200_DEVELOP_116_4_1011C1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1242\/dev.111.2.287","article-title":"Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum","volume":"111","author":"Davis","year":"1991","journal-title":"Development"},{"key":"2024121722362211200_DEVELOP_116_4_1011C2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1242\/dev.105.1.61","article-title":"A whole-mount immunocytochemical analysis of the expression of the intermediate filament protein vimentin in Xenopus","volume":"105","author":"Dent","year":"1989","journal-title":"Development"},{"key":"2024121722362211200_DEVELOP_116_4_1011C3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0896-6273(90)90108-R","article-title":"The effects of N-cadherin misexpression on morphogenesis in Xenopus embryos","volume":"4","author":"Detrick","year":"1990","journal-title":"Neuron"},{"key":"2024121722362211200_DEVELOP_116_4_1011C4","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/332604a0","article-title":"Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis","volume":"332","author":"DiNardo","year":"1988","journal-title":"Nature"},{"key":"2024121722362211200_DEVELOP_116_4_1011C5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1242\/dev.110.1.97","article-title":"Ectopic expression of N-cadherin perturbs histogenesis in Xenopus embryos","volume":"110","author":"Fujimori","year":"1990","journal-title":"Development"},{"key":"2024121722362211200_DEVELOP_116_4_1011C6","doi-asserted-by":"crossref","first-page":"8235","DOI":"10.1073\/pnas.83.21.8235","article-title":"Antibodies to liver cell adhesion molecule perturb inductive interactions and alter feather pattern and structure","volume":"83","author":"Gallin","year":"1986","journal-title":"Proc. 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