{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:26:03Z","timestamp":1785277563556,"version":"3.55.0"},"reference-count":33,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[1993,2,1]],"date-time":"1993-02-01T00:00:00Z","timestamp":728524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The cut locus is both necessary and sufficient to specify the identity of a class of sensory organs in Drosophila embryos. It is also expressed in and required for the development of a number of other embryonic tissues, such as the central nervous system, the Malpighian tubules and the tracheal system. We here describe the expression of cut in the precursors of adult sensory organs. We also show that cut is expressed in cells of the prospective wing margin and correlate the wing margin phenotype caused by two cut mutations with altered cut expression patterns. Finally, we observe cut-expressing cells in other adult tissues, including Malpighian tubules, muscles, the central nervous system and ovarian follicle cells.<\/jats:p>","DOI":"10.1242\/dev.117.2.441","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T01:13:40Z","timestamp":1619399620000},"page":"441-450","source":"Crossref","is-referenced-by-count":168,"title":["Postembryonic patterns of expression of <i>cut<\/i>, a locus regulating sensory organ identity in <i>Drosophila<\/i>"],"prefix":"10.1242","volume":"117","author":[{"given":"Karen","family":"Blochlinger","sequence":"first","affiliation":[{"name":"1 Hutchinson Cancer Research, 1124 Columbia Street,Seattle, Washington 98104, USA"},{"name":"University of California 2 Howard Hughes Medical Institute and the Departments of Physiology and Biochemistry , , San Francisco, California 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily Yeh","family":"Jan","sequence":"additional","affiliation":[{"name":"University of California 2 Howard Hughes Medical Institute and the Departments of Physiology and Biochemistry , , San Francisco, California 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh Nung","family":"Jan","sequence":"additional","affiliation":[{"name":"University of California 2 Howard Hughes Medical Institute and the Departments of Physiology and Biochemistry , , San Francisco, California 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1993,2,1]]},"reference":[{"key":"2024121722414011200_DEVELOP_117_2_441C1","first-page":"1","article-title":"Development of sensory systems in arthropods","volume":"IX","author":"Bate","year":"1978","journal-title":"In Handbook of Sensory Physiology"},{"key":"2024121722414011200_DEVELOP_117_2_441C2","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1242\/dev.113.1.79","article-title":"Cells with persistent twist expression are the embryonic precursors of adult muscles in Drosophila","volume":"113","author":"Bate","year":"1991","journal-title":"Development"},{"key":"2024121722414011200_DEVELOP_117_2_441C3","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1101\/gad.3.9.1288","article-title":"P-element mediated enhancer detection: a versatile method to study development in Drosophila","volume":"3","author":"Bellen","year":"1989","journal-title":"Genes Dev"},{"key":"2024121722414011200_DEVELOP_117_2_441C4","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.1016\/0925-4773(92)90033-G","article-title":"The development of normal and ectopic sensilla in the wings of hairy and Hairy wing mutants of Drosophila","volume":"38","author":"Blair","year":"1992","journal-title":"Mech. Dev"},{"key":"2024121722414011200_DEVELOP_117_2_441C5","first-page":"1","article-title":"The production of wing scalloping in Drosophila melanogaster","volume":"49","author":"Blanc","year":"1942","journal-title":"Univ. Calif. Publ. Zool"},{"key":"2024121722414011200_DEVELOP_117_2_441C6","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/333629a0","article-title":"Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila","volume":"333","author":"Blochlinger","year":"1988","journal-title":"Nature"},{"key":"2024121722414011200_DEVELOP_117_2_441C7","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1101\/gad.4.8.1322","article-title":"Patterns of expression of Cut, a protein required for external sensory organ development, in wild-type and cut mutant Drosophila embryos","volume":"4","author":"Blochlinger","year":"1990","journal-title":"Genes Dev"},{"key":"2024121722414011200_DEVELOP_117_2_441C8","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1101\/gad.5.7.1124","article-title":"Transformation of sensory organ identity by ectopic expression of Cut in Drosophila","volume":"5","author":"Blochlinger","year":"1991","journal-title":"Genes Dev"},{"key":"2024121722414011200_DEVELOP_117_2_441C9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0092-8674(87)90156-5","article-title":"Transformation of sensory organs by mutations of the cut locus of D. melanogaster","volume":"51","author":"Bodmer","year":"1987","journal-title":"Cell"},{"key":"2024121722414011200_DEVELOP_117_2_441C10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0896-6273(89)90112-8","article-title":"Neurogenesis of the peripheral nervous system in Drosophila embryos","volume":"3","author":"Bodmer","year":"1989","journal-title":"Neuron"},{"key":"2024121722414011200_DEVELOP_117_2_441C11","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/jez.1400840302","article-title":"The effect of puncture on the developing wing of several mutants of Drosophila melanogaster","volume":"84","author":"Braun","year":"1940","journal-title":"J. Exp. Zool"},{"key":"2024121722414011200_DEVELOP_117_2_441C12","first-page":"229","article-title":"Pattern formation in imaginal discs","volume-title":"In The Genetics and Biology of Drosophila","author":"Bryant","year":"1978"},{"key":"2024121722414011200_DEVELOP_117_2_441C13","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1101\/gad.5.6.996","article-title":"Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal disc","volume":"5","author":"Cubas","year":"1991","journal-title":"Genes Dev"},{"key":"2024121722414011200_DEVELOP_117_2_441C14","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/BF00383486","article-title":"Cellular degeneration in the production of some mutant phenotypes in Drosophila melanogaster","volume":"103","author":"Fristrom","year":"1969","journal-title":"Molec. Gen. Genetics"},{"key":"2024121722414011200_DEVELOP_117_2_441C15","first-page":"535","article-title":"Gen und Aussencharakter III","volume":"55","author":"Goldschmidt","year":"1935","journal-title":"Biol.Zentralbl"},{"key":"2024121722414011200_DEVELOP_117_2_441C16","doi-asserted-by":"publisher","DOI":"10.1242\/dev.107.2.389","article-title":"Development of adult sensilla on the wing and notum of Drosophila melanogaster","volume":"107","author":"Hartenstein","year":"1989","journal-title":"Development"},{"key":"2024121722414011200_DEVELOP_117_2_441C17","doi-asserted-by":"publisher","DOI":"10.1242\/dev.111.4.1087","article-title":"The emergence of sense organs in the wing disc of Drosophila","volume":"111","author":"Huang","year":"1991","journal-title":"Development"},{"key":"2024121722414011200_DEVELOP_117_2_441C18","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/0092-8674(85)90283-1","article-title":"Molecular organization of the cut locus of Drosophila melanogaster","volume":"42","author":"Jack","year":"1985","journal-title":"Cell"},{"key":"2024121722414011200_DEVELOP_117_2_441C19","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1242\/dev.113.3.735","article-title":"Expression of the cut locus in the Drosophila wing margin is required for cell type specification and is regulated by a distant enhancer","volume":"113","author":"Jack","year":"1991","journal-title":"Development"},{"key":"2024121722414011200_DEVELOP_117_2_441C20","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1523\/JNEUROSCI.05-09-02453.1985","article-title":"Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster","volume":"5","author":"Jan","year":"1985","journal-title":"J. Neurosci"},{"key":"2024121722414011200_DEVELOP_117_2_441C21","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/genetics\/92.2.485","article-title":"Analysis of the cut locus of Drosophila melanogaster","volume":"92","author":"Johnson","year":"1979","journal-title":"Genetics"},{"key":"2024121722414011200_DEVELOP_117_2_441C22","first-page":"120","volume-title":"The Genome of Drosophila melanogaster","author":"Lindsley","year":"1992"},{"key":"2024121722414011200_DEVELOP_117_2_441C23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1093\/genetics\/127.1.151","article-title":"Four distinct regulatory regions of the cut locus and their effect on cell type specification in Drosophila","volume":"127","author":"Liu","year":"1991","journal-title":"Genetics"},{"key":"2024121722414011200_DEVELOP_117_2_441C24","first-page":"141","article-title":"Oogenesis","volume-title":"In Genetics and Biology of Drosophila","author":"Mahowald","year":"1978"},{"key":"2024121722414011200_DEVELOP_117_2_441C25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/0012-1606(84)90082-4","article-title":"Neuron differentiation and axon growth in the developing wing of Drosophila melanogaster","volume":"104","author":"Murray","year":"1984","journal-title":"Dev. Biol"},{"key":"2024121722414011200_DEVELOP_117_2_441C26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00576805","article-title":"The ultrastructure of the developing leg of Drosophila melanogaster","volume":"166","author":"Poodry","year":"1970","journal-title":"Wilhelm Roux\u2019s Arch. EntwMech. Org"},{"key":"2024121722414011200_DEVELOP_117_2_441C27","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/0166-2236(89)90166-5","article-title":"A multifaceted approach to neural development","volume":"12","author":"Ready","year":"1989","journal-title":"Trends in Neurosci"},{"key":"2024121722414011200_DEVELOP_117_2_441C28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0092-8674(81)90008-8","article-title":"Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila","volume":"66","author":"Ruohola","year":"1991","journal-title":"Cell"},{"key":"2024121722414011200_DEVELOP_117_2_441C29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/BF00848431","article-title":"Developmental analysis of two wing scalloping mutants ct6 and BxJ of Drosophila melanogaster","volume":"178","author":"Santamaria","year":"1975","journal-title":"Wilhelm Roux\u2019s Arch. Dev. Biol"},{"key":"2024121722414011200_DEVELOP_117_2_441C30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/BF00573645","article-title":"Anlageplan, Determinationszustand und Transdeterminationsleistungen der mannlichen Vorderbeinscheibe von Drosophila melanogaster","volume":"160","author":"Schubiger","year":"1968","journal-title":"Wilhelm Roux Arch. EntwMech. Org"},{"key":"2024121722414011200_DEVELOP_117_2_441C31","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1101\/gad.5.6.984","article-title":"Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing","volume":"5","author":"Skeath","year":"1991","journal-title":"Genes Dev"},{"key":"2024121722414011200_DEVELOP_117_2_441C32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BF02982977","article-title":"The genetic control of wing development in Drosophila","volume":"41","author":"Waddington","year":"1940","journal-title":"J. Genetics"},{"key":"2024121722414011200_DEVELOP_117_2_441C33","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1007\/BF00848158","article-title":"Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. III. Zygotic loci on the X-chromosome and fourth chromosome","volume":"193","author":"Wieschaus","year":"1984","journal-title":"Wilhelm Roux\u2019s Arch. Dev. Biol"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/117\/2\/441\/3590320\/develop_117_2_441.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/117\/2\/441\/3590320\/develop_117_2_441.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T22:41:57Z","timestamp":1734475317000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/117\/2\/441\/37714\/Postembryonic-patterns-of-expression-of-cut-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2,1]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,2,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.117.2.441","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,2,1]]}}}