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The EMX transcription factors are essential for early patterning of the cerebral cortex, but whether EMX1 mediates interhemispheric connectivity by controlling corpus callosum formation remains unclear. Here, we demonstrate that in mice on the C57Bl\/6 background EMX1 plays an essential role in the midline crossing of an axonal subpopulation of the corpus callosum derived from the anterior cingulate cortex. In the absence of EMX1, cingulate axons display reduced expression of the axon guidance receptor NRP1 and form aberrant axonal bundles within the rostral corpus callosum. EMX1 also functions as a transcriptional activator of Nrp1 expression in vitro, and overexpression of this protein in Emx1 knockout mice rescues the midline-crossing phenotype. These findings reveal a novel role for the EMX1 transcription factor in establishing cortical connectivity by regulating the interhemispheric wiring of a subpopulation of neurons within the mouse anterior cingulate cortex.<\/jats:p>","DOI":"10.1242\/dev.119909","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T12:42:47Z","timestamp":1446554567000},"page":"3746-3757","source":"Crossref","is-referenced-by-count":23,"title":["EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex"],"prefix":"10.1242","volume":"142","author":[{"given":"Jonathan W. 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