{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:03:39Z","timestamp":1760551419294,"version":"3.30.2"},"reference-count":54,"publisher":"The Company of Biologists","issue":"10","license":[{"start":{"date-parts":[[1994,10,1]],"date-time":"1994-10-01T00:00:00Z","timestamp":780969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Pax 1 is a member of the paired-box containing gene family. Expression has previously been observed in the developing sclerotomes and later in the anlagen of the intervertebral discs. Analysis of Pax 1-deficient undulated mice revealed an important role for this gene in the development of the axial skeleton, in which Pax 1 apparently functions as a mediator of notochordal signals during sclerotome differentiation. Here we demonstrate that Pax 1 is also transiently expressed in the developing limb buds. A comparative phenotypic analysis of different undulated alleles shows that this expression is of functional significance. In mice that are mutant for the Pax 1 gene severe developmental abnormalities are found in the pectoral girdle. These include fusions of skeletal elements which would normally remain separate, and failures in the differentiation of blastemas into cartilaginous structures. Although Pax 1 is also expressed in the developing hindlimb buds and Wolffian ridge, no malformations could be detected in the corresponding regions of Pax 1 mutant mice. These findings show that, in addition to its role in the developing vertebral column, Pax 1 has an important function in the development of parts of the appendicular skeleton.<\/jats:p>","DOI":"10.1242\/dev.120.10.2773","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T01:31:46Z","timestamp":1619400706000},"page":"2773-2785","source":"Crossref","is-referenced-by-count":60,"title":["Expression and function of <i>Pax 1<\/i> during development of the pectoral girdle"],"prefix":"10.1242","volume":"120","author":[{"given":"Paula M.","family":"Timmons","sequence":"first","affiliation":[{"name":"1 Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Wallin","sequence":"additional","affiliation":[{"name":"2 Max Planck Institute of Immunobiology, Department of Developmental Biology, 79108 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W. J.","family":"Rigby","sequence":"additional","affiliation":[{"name":"1 Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudi","family":"Balling","sequence":"additional","affiliation":[{"name":"2 Max Planck Institute of Immunobiology, Department of Developmental Biology, 79108 Freiburg, Germany"},{"name":"3 Institut f\u00fcr S\u00e4ugetiergenetik, GSF-Forschungszentrum, 85758 Oberschlei\u00dfheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1994,10,1]]},"reference":[{"key":"2024121723464275900_DEVELOP_120_10_2773C1","first-page":"323","article-title":"Spatiotemporal distribution of a zone that controls antero-posterior polarity in the limb bud of the chick and other bird embryos","volume":"10","author":"Balcuns","year":"1970","journal-title":"Am Zool"},{"key":"2024121723464275900_DEVELOP_120_10_2773C2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/0092-8674(88)90039-6","article-title":"undulated, a mutation affecting the development of the mouse skeleton has a point mutation in the paired box of Pax-1","volume":"55","author":"Balling","year":"1988","journal-title":"Cell"},{"key":"2024121723464275900_DEVELOP_120_10_2773C3","first-page":"132","article-title":"Development of the skeletal system","volume-title":"Ciba Foundation Symposium","author":"Balling","year":"1992"},{"key":"2024121723464275900_DEVELOP_120_10_2773C4","first-page":"99","article-title":"Brachial muscles in the chick embryo. the fate of individual somites","volume":"77","author":"Beresford","year":"1983","journal-title":"J. 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