{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:20:16Z","timestamp":1790194816907,"version":"4.1.0"},"reference-count":64,"publisher":"The Company of Biologists","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>FGF-3 has been implicated in the development of the hindbrain and otocyst in vertebrate embryos. Since the chicken embryo offers a favourable system in which to study the development of these structures, we have isolated and characterised cDNAs for chicken Fgf-3 and determined its pattern of expression in chick embryos from stage 3 (primitive streak) to stage 25 (early organogenesis). Within the developing cranial neural tube, Fgf-3 exhibits dynamic spatial and temporal expression. During extension of the head process, RNA is detected in the midline of the developing neural plate. In neurulating embryos, transcripts are observed initially in rhombomeres 4 and 5 of the hindbrain and later, in rhombomere 6. During hindbrain development, expression is lost from these rhombomeres, but becomes restricted to rhombomere boundaries, providing an intracellular marker which distinguishes a population of cells within boundary regions. Fgf-3 expression is elevated in ventral and medial boundary regions and is greatly reduced in dorsal parts. Studies of regenerating rhombomere boundaries show that Fgf-3 expression is induced in reforming boundaries when evennumbered rhombomere tissue is grafted next to odd, but not when like is juxtaposed to like. Fgf-3 disappears from boundary regions just prior to the loss of the morphological boundaries suggesting a boundary-associated function.<\/jats:p>\n               <jats:p>Other sites of expression have also been identified. At early stages of development Fgf-3 is expressed in the epiblast and mesendoderm of the primitive streak, in mesoderm lateral to the streak and in Hensen\u2019s node. In older embryos transcripts are detected in the endoderm of the pharyngeal pouches, the ectoderm of the second and third pharyngeal arches and the stomodeum. Expression was also detected in the segmental plate and in the posterior half of the three most-recently generated somites.<\/jats:p>","DOI":"10.1242\/dev.121.5.1399","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T02:20:08Z","timestamp":1619403608000},"page":"1399-1410","source":"Crossref","is-referenced-by-count":147,"title":["Multiple roles for FGF-3 during cranial neural development in the chicken"],"prefix":"10.1242","volume":"121","author":[{"given":"Radma","family":"Mahmood","sequence":"first","affiliation":[{"name":"MRC Brain Development Programme 1 , Division of Anatomy and Cell Biology, UMDS Guy\u2019s and St. Thomas\u2019 Hospitals, Guy\u2019s Campus, London SE1 9RT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Viral Carcinogenesis Laboratory 2 , Imperial Cancer Research Fund, Lincoln\u2019s Inn Fields, London WC2A 3PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Guthrie","sequence":"additional","affiliation":[{"name":"MRC Brain Development Programme 1 , Division of Anatomy and Cell Biology, UMDS Guy\u2019s and St. Thomas\u2019 Hospitals, Guy\u2019s Campus, London SE1 9RT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Dickson","sequence":"additional","affiliation":[{"name":"Viral Carcinogenesis Laboratory 2 , Imperial Cancer Research Fund, Lincoln\u2019s Inn Fields, London WC2A 3PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivor","family":"Mason","sequence":"additional","affiliation":[{"name":"MRC Brain Development Programme 1 , Division of Anatomy and Cell Biology, UMDS Guy\u2019s and St. Thomas\u2019 Hospitals, Guy\u2019s Campus, London SE1 9RT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1995,5,1]]},"reference":[{"key":"2025011513570353700_DEVELOP_121_5_1399C1","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/343662a0","article-title":"Subcelluar fate of the Int-2 oncoprotein is determined by choice of initiation codon","volume":"343","author":"Acland","year":"1990","journal-title":"Nature"},{"key":"2025011513570353700_DEVELOP_121_5_1399C2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/cne.900390103","article-title":"The development of the neural folds and cranial ganglia of the rat","volume":"39","author":"Adelman","year":"1925","journal-title":"J. Comp. Neurol"},{"key":"2025011513570353700_DEVELOP_121_5_1399C3","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1002\/neu.480241007","article-title":"Fate and potentialities of the avian mesencephalic\/metencephalic neuroepithelium","volume":"24","author":"Alvarado-Mallart","year":"1993","journal-title":"J. Neurobiol"},{"key":"2025011513570353700_DEVELOP_121_5_1399C4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/ar.1092280311","article-title":"Shaping, invagination and closure of the chick embryo otic vesicle","volume":"228","author":"Alvarez","year":"1990","journal-title":"Anat. Rec"},{"key":"2025011513570353700_DEVELOP_121_5_1399C5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/B978-1-4832-3142-6.50010-0","article-title":"Development in birds","volume-title":"Birds and Comparative Physiology of Birds","author":"Bellairs","year":"1960"},{"key":"2025011513570353700_DEVELOP_121_5_1399C6","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1242\/dev.120.6.1347","article-title":"Violation of cell lineage restriction compartments in the chick hindbrain","volume":"120","author":"Birgbauer","year":"1994","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C7","first-page":"429","article-title":"Sequence organisation of the human int-2 gene and its expression in teratocarcinoma cells","volume":"4","author":"Brookes","year":"1989","journal-title":"Oncogene"},{"key":"2025011513570353700_DEVELOP_121_5_1399C8","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/294092a0","article-title":"Introduction of a rabbit \u03b2-globin gene into the mouse germ line","volume":"294","author":"Costantini","year":"1981","journal-title":"Nature"},{"key":"2025011513570353700_DEVELOP_121_5_1399C9","first-page":"4896","article-title":"Detection and characterisation of the fibroblast-growth factor-related INT-2","volume":"9","author":"Dixon","year":"1989","journal-title":"Mol. Cell. Biol"},{"key":"2025011513570353700_DEVELOP_121_5_1399C10","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/0092-8674(93)90627-3","article-title":"Sonic hedgehog, a member of a family of putative signalling molecules, is implicated in the regulation of CNS polarity","volume":"75","author":"Echelard","year":"1993","journal-title":"Cell"},{"key":"2025011513570353700_DEVELOP_121_5_1399C11","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/344431a0","article-title":"Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions","volume":"344","author":"Fraser","year":"1990","journal-title":"Nature"},{"key":"2025011513570353700_DEVELOP_121_5_1399C12","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1242\/dev.117.3.925","article-title":"Altered rhombomere-specific expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr)","volume":"117","author":"Frohman","year":"1993","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/1044-5765(92)90020-3","article-title":"Patterning the rostrocaudal axis of the hindbrain","volume":"4","author":"Graham","year":"1992","journal-title":"Sem. Neurosci"},{"key":"2025011513570353700_DEVELOP_121_5_1399C14","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1242\/dev.119.1.233","article-title":"Even-numbered rhombomeres control the elimination of neural crest cells from odd-numbered rhombomeres in the chick hindbrain","volume":"119","author":"Graham","year":"1993","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C15","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/372684a0","article-title":"The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest","volume":"372","author":"Graham","year":"1994","journal-title":"Nature"},{"key":"2025011513570353700_DEVELOP_121_5_1399C16","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/BF02980506","article-title":"Die Rhombomeren und ihre Nervenbeziehungen","volume":"83","author":"Gr\u00e4per","year":"1913","journal-title":"Arch. Mikrosk. Anat"},{"key":"2025011513570353700_DEVELOP_121_5_1399C17","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1242\/dev.112.1.221","article-title":"Formation and regeneration of rhombomere boundaries in the developing chick hindbrain","volume":"112","author":"Guthrie","year":"1991","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C18","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1002\/neu.480220709","article-title":"Patterns of cell division and interkinetic nuclear migration in the chick embryo hindbrain","volume":"22","author":"Guthrie","year":"1991","journal-title":"J. Neurobiol"},{"key":"2025011513570353700_DEVELOP_121_5_1399C19","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1242\/dev.114.3.663","article-title":"Motor neuron pathfinding following rhombomere reversals in the chick embryo hindbrain","volume":"114","author":"Guthrie","year":"1992","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C20","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1242\/dev.118.2.527","article-title":"Selective dispersal of avian rhombomere boundary cells in orthotopic and heterotopic grafts","volume":"118","author":"Guthrie","year":"1993","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J. Morphol"},{"key":"2025011513570353700_DEVELOP_121_5_1399C22","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/aja.1001980402","article-title":"Cellular morphology and extracellular space at rhombomere boundaries in the chick embryo hindbrain","volume":"198","author":"Heyman","year":"1993","journal-title":"Dev. Dynamics"},{"key":"2025011513570353700_DEVELOP_121_5_1399C23","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1242\/dev.119.4.1147","article-title":"Cwnt-8C: a novel wnt gene with a potential role in primitive streak formation and hindbrain organisation","volume":"119","author":"Hume","year":"1993","journal-title":"Development"},{"issue":"Suppl","key":"2025011513570353700_DEVELOP_121_5_1399C24","first-page":"185","article-title":"The function and mechanism of convergent extension during gastrulation of Xenopus laevis J","volume":"89","author":"Keller","year":"1985","journal-title":"Embryol. Exp. Morph"},{"key":"2025011513570353700_DEVELOP_121_5_1399C25","first-page":"5929","article-title":"The int-2\/Fgf-3 oncogene product is secreted and associates with extracellular matrix: implications for cell transformation","volume":"11","author":"Kiefer","year":"1991","journal-title":"Mol. Cell. Biol"},{"key":"2025011513570353700_DEVELOP_121_5_1399C26","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.1002\/j.1460-2075.1993.tb06100.x","article-title":"FGF-3 from Xenopus laevis","volume":"12","author":"Kiefer","year":"1993","journal-title":"EMBO J"},{"key":"2025011513570353700_DEVELOP_121_5_1399C27","first-page":"5781","article-title":"Retention of fibroblast growth factor 3 in the Golgi complex may regulate its export from cells","volume":"13","author":"Kiefer","year":"1993","journal-title":"Mol. Cell. Biol"},{"key":"2025011513570353700_DEVELOP_121_5_1399C28","doi-asserted-by":"publisher","first-page":"4126","DOI":"10.1002\/j.1460-2075.1994.tb06730.x","article-title":"Competition between nuclear localisation and secretory signals determines the subcellular fate of a single CUG-initiated form of FGF-3","volume":"13","author":"Kiefer","year":"1994","journal-title":"EMBO J"},{"key":"2025011513570353700_DEVELOP_121_5_1399C29","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/jez.1401970205","article-title":"Changes in the shape of the developing vertebrate nervous system analysed experimentally, mathematically and by computer simulation","volume":"197","author":"Jacobson","year":"1976","journal-title":"J. Exp. Zool"},{"key":"2025011513570353700_DEVELOP_121_5_1399C30","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1242\/dev.109.3.613","article-title":"Patterning of chick brain vesicles as revealed by peanut agglutinin and cholinesterases","volume":"109","author":"Layer","year":"1990","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0166-2236(90)90144-Y","article-title":"The cellular basis of segmentation in the developing hindbrain","volume":"13","author":"Lumsden","year":"1990","journal-title":"Trends Neurosci"},{"key":"2025011513570353700_DEVELOP_121_5_1399C32","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/337424a0","article-title":"Segmental patterns of neuronal development in the chick hindbrain","volume":"337","author":"Lumsden","year":"1989","journal-title":"Nature"},{"key":"2025011513570353700_DEVELOP_121_5_1399C33","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1242\/dev.113.4.1281","article-title":"Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo","volume":"113","author":"Lumsden","year":"1991","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1242\/dev.117.1.13","article-title":"Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear","volume":"117","author":"Mansour","year":"1993","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C35","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/j.1460-9568.1989.tb00362.x","article-title":"Rostral cerebellum originates from the caudal portion of the so-called \u2018mesencephalic\u2019 vesicle: a study using chick\/quail chimeras","volume":"1","author":"Martinez","year":"1989","journal-title":"Eur. J. Neurosci"},{"key":"2025011513570353700_DEVELOP_121_5_1399C36","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1242\/dev.116.4.1069","article-title":"Reduced junctional permiability at interrhombomeric boundaries","volume":"116","author":"Martinez","year":"1992","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C37","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/0092-8674(94)90520-7","article-title":"The ins and outs of fibroblast growth factors","volume":"78","author":"Mason","year":"1994","journal-title":"Cell"},{"key":"2025011513570353700_DEVELOP_121_5_1399C38","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1242\/dev.120.8.2199","article-title":"The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres","volume":"120","author":"McKay","year":"1994","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C39","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/ar.1091910405","article-title":"Development of the chick otic placode","volume":"191","author":"Meier","year":"1978","journal-title":"Anat. Rec"},{"key":"2025011513570353700_DEVELOP_121_5_1399C40","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/j.1460-2075.1986.tb04304.x","article-title":"Sequence, topography and protein coding potential of mouse int-2 : a putative oncogene activated by mouse mammary tumour virus","volume":"5","author":"Moore","year":"1986","journal-title":"EMBO J"},{"key":"2025011513570353700_DEVELOP_121_5_1399C41","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1242\/dev.116.4.1137","article-title":"A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm","volume":"116","author":"Nieto","year":"1992","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C42","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1126\/science.7513443","article-title":"Control of cell behaviour during vertebrate development by Slug, a zinc finger gene","volume":"264","author":"Nieto","year":"1994","journal-title":"Science"},{"key":"2025011513570353700_DEVELOP_121_5_1399C43","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1242\/dev.114.3.755","article-title":"Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse","volume":"114","author":"Niswander","year":"1992","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C44","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/371609a0","article-title":"A positive feedback loop coordinates growth and patterning in the vertebrate limb","volume":"371","author":"Niswander","year":"1994","journal-title":"Nature"},{"key":"2025011513570353700_DEVELOP_121_5_1399C45","first-page":"121","article-title":"Interactions and fates of avian craniofacial mesenchyme","volume-title":"Development","author":"Noden","year":"1988"},{"key":"2025011513570353700_DEVELOP_121_5_1399C46","first-page":"1","article-title":"The development of craniofacial blood vessels","volume":"14","author":"Noden","year":"1991","journal-title":"The Development of the Vascular System"},{"key":"2025011513570353700_DEVELOP_121_5_1399C47","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1242\/dev.106.1.79","article-title":"Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF","volume":"106","author":"Paterno","year":"1989","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C48","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1242\/dev.120.4.911","article-title":"Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest","volume":"120","author":"Prince","year":"1994","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C49","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/353561a0","article-title":"The int-2 protooncogene is responsible for induction of the inner ear","volume":"353","author":"Represa","year":"1991","journal-title":"Nature"},{"key":"2025011513570353700_DEVELOP_121_5_1399C50","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","article-title":"Sonic hedgehog mediates the polarising activity of the ZPA","volume":"75","author":"Riddle","year":"1993","journal-title":"Cell"},{"key":"2025011513570353700_DEVELOP_121_5_1399C51","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1242\/dev.116.1.81","article-title":"Pintallavis, a gene expressed in the organiser midline cells of frog embryos: involvement in the development of the neural axis","volume":"116","author":"Ruiz i Altaba","year":"1992","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C52","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1242\/dev.118.1.47","article-title":"Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo","volume":"118","author":"Sasaki","year":"1993","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C53","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1242\/dev.109.2.243","article-title":"Mechanisms of neurulation: traditional viewpoint and recent advances","volume":"109","author":"Schoenwolf","year":"1990","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C54","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1242\/dev.120.7.1777","article-title":"Rhombomere rotation reveals that multiple mechanisms contribute to the segmental pattern of hindbrain neural crest migration","volume":"120","author":"Sechrist","year":"1994","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C55","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1242\/dev.112.2.615","article-title":"Fate mapping and lineage analysis of Hensen\u2019s node in the chick embryo","volume":"112","author":"Selleck","year":"1991","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C56","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0960-9822(94)00027-8","article-title":"Inducing factors in Xenopus early embryos","volume":"4","author":"Slack","year":"1994","journal-title":"Curr. Biol"},{"key":"2025011513570353700_DEVELOP_121_5_1399C57","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1242\/dev.115.3.695","article-title":"Developmental expression of the Xenopus int-2 (FGF-3) gene: activation by meseodermal and neural induction","volume":"115","author":"Tannahill","year":"1992","journal-title":"Development"},{"key":"2025011513570353700_DEVELOP_121_5_1399C58","first-page":"1","article-title":"The segmentation of the primitive neural tube in chick embryos (Gallus domesticus)","volume":"41","author":"Vaage","year":"1969","journal-title":"Adv. Anat. Embryol. Cell Biol"},{"key":"2025011513570353700_DEVELOP_121_5_1399C59","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/j.1749-6632.1991.tb19580.x","article-title":"Tissue interactions and growth factors that control development of the inner ear","volume":"630","author":"Van de Water","year":"1991","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"2025011513570353700_DEVELOP_121_5_1399C60","doi-asserted-by":"publisher","first-page":"4683","DOI":"10.1093\/nar\/14.11.4683","article-title":"A new method for predicting signal sequence cleavage sites","volume":"14","author":"von Heijne","year":"1986","journal-title":"Nucl. Acids Res"},{"key":"2025011513570353700_DEVELOP_121_5_1399C61","volume-title":"In: In situ hybridisation: A Practical Approach","author":"Wilkinson","year":"1992"},{"key":"2025011513570353700_DEVELOP_121_5_1399C62","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/bies.950150802","article-title":"Molecular mechanisms of segmental patterning in the vertebrate hindbrain and neural crest","volume":"15","author":"Wilkinson","year":"1993","journal-title":"BioEssays"},{"key":"2025011513570353700_DEVELOP_121_5_1399C63","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1002\/j.1460-2075.1988.tb02864.x","article-title":"Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse","volume":"7","author":"Wilkinson","year":"1988","journal-title":"EMBO J"},{"key":"2025011513570353700_DEVELOP_121_5_1399C64","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1242\/dev.105.1.131","article-title":"Expression of FGFrelated proto-oncogene int-2 suggests multiple roles in development","volume":"105","author":"Wilkinson","year":"1989","journal-title":"Development"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/121\/5\/1399\/3118873\/develop_121_5_1399.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/121\/5\/1399\/3118873\/develop_121_5_1399.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T13:57:37Z","timestamp":1736949457000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/121\/5\/1399\/38701\/Multiple-roles-for-FGF-3-during-cranial-neural"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,1]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.121.5.1399","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,1]]}}}