{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:00:23Z","timestamp":1791039623448,"version":"4.1.0"},"reference-count":41,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The let-23 receptor tyrosine kinase gene is required for vulval induction and larval survival in the nematode Caenorhabditis elegans. We carried out genetic mosaic analyses of the let-23 gene function by using the cloned let-23 and ncl-1 genes. The wild-type let-23 gene was required in a vulval precursor cell to adopt the 1\u00b0 vulval fate in animals carrying a let-23 vulvaless or lethal chromosomal mutation. In almost all the animals, vulval precursor cells adjacent to a 1\u00b0 fate cell were induced to the 2\u00b0 vulval fate regardless of the let-23 genotypes. These findings indicate that the vulval induction signal from an anchor cell induces a vulval precursor cell to adopt the 1\u00b0 fate through LET-23, and then a 1\u00b0 fate cell induces adjacent cells to adopt the 2\u00b0 fate, for which LET-23 is not required. Foci of lethality of the let-23 (mn23) mutation were found in ABal and ABplp lineages.<\/jats:p>","DOI":"10.1242\/dev.121.8.2655","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T22:27:33Z","timestamp":1619389653000},"page":"2655-2666","source":"Crossref","is-referenced-by-count":74,"title":["Mosaic analysis of the\n                    <i>let-23<\/i>\n                    gene function in vulval induction of\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1242","volume":"121","author":[{"given":"Makoto","family":"Koga","sequence":"first","affiliation":[{"name":"Kyushu University, Hakozaki Department of Biology, Faculty of Science , , Higashi-ku, Fukuoka 812-81, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Kyushu University, Hakozaki Department of Biology, Faculty of Science , , Higashi-ku, Fukuoka 812-81, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1995,8,1]]},"reference":[{"key":"2025011514551576400_DEVELOP_121_8_2655C1","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/348693a0","article-title":"The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily","volume":"348","author":"Aroian","year":"1990","journal-title":"Nature"},{"key":"2025011514551576400_DEVELOP_121_8_2655C2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/genetics\/128.2.251","article-title":"Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction","volume":"128","author":"Aroian","year":"1991","journal-title":"Genetics"},{"key":"2025011514551576400_DEVELOP_121_8_2655C3","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/348503a0","article-title":"The Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction","volume":"348","author":"Beitel","year":"1990","journal-title":"Nature"},{"key":"2025011514551576400_DEVELOP_121_8_2655C4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"2025011514551576400_DEVELOP_121_8_2655C5","first-page":"337","article-title":"The nervous system","volume-title":"The Nematode Caenorhabditis elegans","author":"Chalfie","year":"1988"},{"key":"2025011514551576400_DEVELOP_121_8_2655C6","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/356340a0","article-title":"C. elegans cell-signaling gene sem-5 encodes a protein with SH2 and SH3 domains","volume":"356","author":"Clark","year":"1992","journal-title":"Nature"},{"key":"2025011514551576400_DEVELOP_121_8_2655C7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/genetics\/110.1.17","article-title":"Identification and characterization of 22 genes that affect the vulval cell lineages of Caenorhabditis elegans","volume":"110","author":"Ferguson","year":"1985","journal-title":"Genetics"},{"key":"2025011514551576400_DEVELOP_121_8_2655C8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/326259a0","article-title":"A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans","volume":"326","author":"Ferguson","year":"1987","journal-title":"Nature"},{"key":"2025011514551576400_DEVELOP_121_8_2655C9","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1002\/j.1460-2075.1986.tb04550.x","article-title":"Integrative transformation of Caenorhabditis elegans","volume":"5","author":"Fire","year":"1986","journal-title":"EMBO J"},{"key":"2025011514551576400_DEVELOP_121_8_2655C10","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/0092-8674(83)90377-X","article-title":"The lin-12 locus specifies cell fates in Caenorhabditis elegans","volume":"34","author":"Greenwald","year":"1983","journal-title":"Cell"},{"key":"2025011514551576400_DEVELOP_121_8_2655C11","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1093\/genetics\/126.4.899","article-title":"The let-60 locus controls the switch between vulval and non-vulval cell types in C","volume":"126","author":"Han","year":"1990","journal-title":"elegans. 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