{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:06:56Z","timestamp":1791176816707,"version":"4.1.0"},"reference-count":77,"publisher":"The Company of Biologists","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The lin-2 gene is required for the induction of the Caenorhabditis elegans vulva. Vulval development is initiated by a signal from the anchor cell that is transduced by a receptor tyrosine kinase\/Ras pathway. We show that lin-2 acts in the vulval precursor cell P6.p, downstream of lin-3 EGF and upstream of let-60 ras, to allow expression of the 1\u00b0 cell fate. lin-2 encodes a protein of relative molecular mass 109,000 (LIN-2A) with regions of similar-ity to CaM kinase II and membrane-associated guanylate kinases. Mutant lin-2 transgenes designed to lack either protein kinase or guanylate kinase activity are functional, indicating that LIN-2A has a structural rather than an enzymatic role in vulval induction. Most or all identified membrane-associated guanylate kinases are components of cell junctions, including vertebrate tight junctions and arthropod septate junctions in epithelia. Thus, LIN-2A may be a component of the cell junctions of the epithelial vulval precursor cells that is required for signaling by the receptor tyrosine kinase LET-23. We propose that LIN-2A is required for the localization of one or more signal trans-duction proteins (such as LET-23) to either the basal membrane domain or the cell junctions, and that mislocal-ization of signal transduction proteins in lin-2 mutants interferes with vulval induction.<\/jats:p>","DOI":"10.1242\/dev.122.1.97","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T02:30:43Z","timestamp":1619404243000},"page":"97-111","source":"Crossref","is-referenced-by-count":172,"title":["The <i>C. elegans<\/i> vulval induction gene <i>lin-2<\/i> encodes a member of the MAGUK family of cell junction proteins"],"prefix":"10.1242","volume":"122","author":[{"given":"Roger","family":"Hoskins","sequence":"first","affiliation":[{"name":"Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex F.","family":"Hajnal","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey A.","family":"Harp","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1996,1,1]]},"reference":[{"key":"2025021322400564900_DEVELOP_122_1_97C1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0925-4773(92)90014-B","article-title":"Epithelial polarity and cell separation in the neoplastic l(1)dlg-1 mutant of Drosophila","volume":"37","author":"Abbott","year":"1992","journal-title":"Mech. 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