{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:35:10Z","timestamp":1789846510194,"version":"4.0.1"},"reference-count":56,"publisher":"The Company of Biologists","issue":"10","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Low passage cultured dermal papilla cells from adult rats stimulate complete hair follicle neogenesis when re-implanted into heterotypic skin. In contrast, cultured sheath cells are non-inductive despite sharing other behav-ioural characteristics (a common lineage and in situ proximity) with papilla cells. However, since sheath cells can behave inductively in amputated follicles after regen-erating the papilla, this poses the question of what influ-ences the sheath to papilla cell transition? During recipro-cal tissue interactions specific epidermal cues are crucial to skin appendage development, and while in vivo assays to date have focussed on dermal interactive influence, our aim was to investigate epidermal potential. We have previously observed that hair follicle epidermal cells display excep-tional interactive behaviour when combined with follicle dermal cells in vitro. Thus in the present study, hair follicle germinative, outer root sheath or skin basal epidermal cells were separately combined with each of three non-inductive dermal cell types (high passage papilla, low passage sheath or fibroblast) and then implanted into small ear skin wounds. The sheath\/germinative and papilla\/germinative cell implants repeatedly induced giant vibrissa-type follicles and fibres. In complete contrast, any single cell type and all other forms of recombination were consistently non-inductive. Hence, the adult germinative epidermal cells enable non-inductive adult dermal cells to stimulate hair follicle neogenesis, effectively, by altering their \u2018status\u2019, causing the sheath cells to \u2018specialise\u2019 and the \u2018aged\u2019 papilla cells to \u2018rejuvenate\u2019.<\/jats:p>","DOI":"10.1242\/dev.122.10.3085","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T02:31:44Z","timestamp":1619404304000},"page":"3085-3094","source":"Crossref","is-referenced-by-count":78,"title":["Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells"],"prefix":"10.1242","volume":"122","author":[{"given":"Amanda J.","family":"Reynolds","sequence":"first","affiliation":[{"name":"University of Durham, South Road Department of Biological Sciences , , Durham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin A. 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