{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:27:28Z","timestamp":1791149248557,"version":"4.1.0"},"reference-count":59,"publisher":"The Company of Biologists","issue":"10","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Mature osteoclasts specifically express the purple, band 5 isozyme (Acp 5) of tartrate-resistant acid phosphatase, a binuclear metalloenzyme that can generate reactive oxygen species. The function of Acp 5 was investigated by targeted disruption of the gene in mice. Animals homozygous for the null Acp 5 allele had progressive foreshortening and deformity of the long bones and axial skeleton but apparently normal tooth eruption and skull plate development, indicating a r\u00f4le for Acp 5 in endochondral ossification. Histomorphometry and mineralization density analysis of backscattered electron imaging revealed widened and dis-organized epiphyseal growth plates with delayed mineralization of cartilage in 6- to 8-week-old mutant mice. The membrane bones of the skull showed increased density at all ages examined, indicating defective osteoclastic bone turnover. Increased mineralization density was observed in the long bones of older animals which showed modelling deformities at their extremities: heterozygotes and homozygous Acp 5 mutant mice had tissue that was more mineralized and occupied a greater proportion of the bone in all regions. Thus the findings reflect a mild osteopetrosis due to an intrinsic defect of osteoclastic modelling activity that was confirmed in the resorption pit assay in vitro. We conclude that this bifunctional metalloprotein of the osteoclast is required for normal mineralization of cartilage in developing bones; it also maintains integrity and turnover of the adult skeleton by a critical contribution to bone matrix resorption.<\/jats:p>","DOI":"10.1242\/dev.122.10.3151","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T02:33:26Z","timestamp":1619404406000},"page":"3151-3162","source":"Crossref","is-referenced-by-count":321,"title":["Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis"],"prefix":"10.1242","volume":"122","author":[{"given":"Alison R.","family":"Hayman","sequence":"first","affiliation":[{"name":"1 Department of Medicine, University of Cambridge, Level 5, Addenbrooke\u2019s Hospital, Cambridge CB2 2QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila J.","family":"Jones","sequence":"additional","affiliation":[{"name":"2 Department of Anatomy and Developmental Biology, University College, London, Gower Street, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Boyde","sequence":"additional","affiliation":[{"name":"2 Department of Anatomy and Developmental Biology, University College, London, Gower Street, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Foster","sequence":"additional","affiliation":[{"name":"3 Wellcome Trust\/Cancer Research Campaign Institute of Cancer and Developmental Biology and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Colledge","sequence":"additional","affiliation":[{"name":"3 Wellcome Trust\/Cancer Research Campaign Institute of Cancer and Developmental Biology and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B.","family":"Carlton","sequence":"additional","affiliation":[{"name":"3 Wellcome Trust\/Cancer Research Campaign Institute of Cancer and Developmental Biology and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Evans","sequence":"additional","affiliation":[{"name":"3 Wellcome Trust\/Cancer Research Campaign Institute of Cancer and Developmental Biology and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Cox","sequence":"additional","affiliation":[{"name":"1 Department of Medicine, University of Cambridge, Level 5, Addenbrooke\u2019s Hospital, Cambridge CB2 2QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"2025021323341095400_DEVELOP_122_10_3151C1","volume-title":"Cell Mediated Calcification and Matrix Vesicles","author":"Ali","year":"1986"},{"key":"2025021323341095400_DEVELOP_122_10_3151C2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0169-6009(08)80225-5","article-title":"Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel","volume":"22","author":"Boskey","year":"1993","journal-title":"Bone Miner"},{"key":"2025021323341095400_DEVELOP_122_10_3151C3","first-page":"1259","article-title":"Optical and scanning electron microscopy in the single osteoclast resorption assay","volume":"1985\/III","author":"Boyde","year":"1985","journal-title":"Scann. 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