{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:10:51Z","timestamp":1791335451969,"version":"4.3.1"},"reference-count":57,"publisher":"The Company of Biologists","issue":"10","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Mice were generated with targeted disruptions in the hoxb-1 gene. Two separate mutations were created: the first disrupts only the homeodomain and the second inactivates the first exon as well as the homeodomain. The phenotypes associated with these two mutant alleles are indistinguishable in surviving adult mice. The predominant defect in these mutant mice is a failure to form the somatic motor component of the VIIth (facial) nerve, possibly through a failure to specify these neurons. The phenotype of hoxb-1 mutant homozygotes closely resembles features of the clinical profile associated with humans suffering from Bell\u2019s Palsy or Moebius Syndrome. These animals should therefore provide a useful animal model for these human diseases.<\/jats:p>","DOI":"10.1242\/dev.122.10.3217","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T18:55:21Z","timestamp":1619204121000},"page":"3217-3228","source":"Crossref","is-referenced-by-count":248,"title":["Mice with targeted disruption of <i>Hoxb-1<\/i> fail to form the motor nucleus of the VIIth nerve"],"prefix":"10.1242","volume":"122","author":[{"given":"Judy M.","family":"Goddard,","sequence":"first","affiliation":[{"name":"University of Utah, School of Medicine Howard Hughes Medical Institute, Department of Human Genetics , , Salt Lake City, Utah 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Rossel","sequence":"additional","affiliation":[{"name":"University of Utah, School of Medicine Howard Hughes Medical Institute, Department of Human Genetics , , Salt Lake City, Utah 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy R.","family":"Manley","sequence":"additional","affiliation":[{"name":"University of Utah, School of Medicine Howard Hughes Medical Institute, Department of Human Genetics , , Salt Lake City, Utah 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario R.","family":"Capecchi","sequence":"additional","affiliation":[{"name":"University of Utah, School of Medicine Howard Hughes Medical Institute, Department of Human Genetics , , Salt Lake City, Utah 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"2025021323321816200_DEVELOP_122_10_3217C1","first-page":"1","article-title":"Development of the cranial nerve ganglia and related nuclei in the rat","volume-title":"Advances in Anatomy, Embryology and Cell Biology","author":"Altman","year":"1982"},{"key":"2025021323321816200_DEVELOP_122_10_3217C2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0378-1119(82)90023-3","article-title":"Nucleotide sequence and exact localization of the neomycin phosphotransferase gene from transposon Tn5","volume":"19","author":"Beck","year":"1982","journal-title":"Gene"},{"key":"2025021323321816200_DEVELOP_122_10_3217C3","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1006\/dbio.1996.0159","article-title":"Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations","volume":"177","author":"Boulet","year":"1996","journal-title":"Dev. 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