{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:29:31Z","timestamp":1787984971723,"version":"build-2784847793"},"reference-count":38,"publisher":"The Company of Biologists","issue":"11","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We have undertaken electron micrographic reconstruction of the Caenorhabditis elegans hermaphrodite uterus and determined the correspondence between cells defined by their lineage history and differentiated cell types. In this organ, many cells do not move during morphogenesis and the cell lineage may function to put cells where they are needed. Differentiated uterine cell types include the toroidal ut cells that make structural epithelium, and specialized utse and uv cells that make the connection between the uterus and the vulva. A cell fate decision in which the anchor cell (AC) induces adjacent ventral uterine intermediate precursor cells to adopt the \u03c0 fate, rather than the ground state \u03c1, has profound consequences for terminal differentiation: all \u03c0 progeny are directly involved in making the uterine-vulval connection whereas all \u03c1 progeny contribute to ut toroids or the uterine-spermathecal valve. In addition to specifying certain uterine cell fates, the AC also induces the vulva. Its multiple inductions thereby function to coordinate the connection of an internal to an external epithelium. The AC induces the \u03c0 cells and ultimately fuses with a subset of their progeny. This is an example of reciprocal cell-cell interaction that can be studied at single cell resolution. The AC is thus a transitory cell type that plays a pivotal role in organizing the morphogenesis of the uterine-vulval connection.<\/jats:p>","DOI":"10.1242\/dev.122.11.3617","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T19:01:14Z","timestamp":1619204474000},"page":"3617-3626","source":"Crossref","is-referenced-by-count":135,"title":["Morphogenesis of the <i>C. elegans<\/i> hermaphrodite uterus"],"prefix":"10.1242","volume":"122","author":[{"given":"Anna P.","family":"Newman","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute 1 , Division of Biology 156-29 , , Pasadena, CA 91125, USA"},{"name":"California Institute of Technology 1 , Division of Biology 156-29 , , Pasadena, CA 91125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"White","sequence":"additional","affiliation":[{"name":"2 MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Sternberg","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute 1 , Division of Biology 156-29 , , Pasadena, CA 91125, USA"},{"name":"California Institute of Technology 1 , Division of Biology 156-29 , , Pasadena, CA 91125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1996,11,1]]},"reference":[{"key":"2025021323522986000_DEVELOP_122_11_3617C1","first-page":"299","article-title":"The pharynx of Caenorhabditis elegans. 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