{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:01:29Z","timestamp":1789596089734,"version":"build-2803163510"},"reference-count":24,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The Abdominal B-related Hoxa-10 gene displays similar expression patterns in the differentiating forelimbs and hindlimbs of the mouse, with preferential expression around the humeral and femoral cartilages and more diffuse expression in distal regions. We found that a targeted disruption of Hoxa-10 has almost no effect in the forelimbs, while it affects the proximal hindlimb skeleton. The alterations were located along the dorsolateral side of the femur (labium laterale), with an enlargement and distal shift of the third trochanter, a misshapen lateral knee sesamoid, a supernumerary \u2018ligament\u2019 connecting these structures and an occasional duplication of the femoral trochlea. Some Hoxa-10\u2212\/\u2212 mutant mice developed severe degenerative alterations of the knee articulation upon ageing. Viable Hoxa-10\/Hoxd-11 double mutant mice were produced by genetic intercrosses. The compound mutation resulted in synergistic forelimb phenotypic alterations, consisting of: (i) an exacerbation of Hoxd-11\u2212\/\u2212 phenotypic traits in the carpal and digital region, e.g. more pronounced truncations of the ulna styloid, pyramidal and pisiform bones and of some metacarpal and phalangeal bones and (ii) marked alterations in a more proximal region which is nearly unaffected in Hoxd-11\u2212\/\u2212 single mutants; the entire radius and ulna were truncated and thickened, with deformations of the ulna proximal extremity. Thus, functional redundancy can occur even between non-paralogous Abdominal B-related Hox genes. The double Hoxa-10\/Hoxd-11 mutation also conferred full penetrance to the sacral and caudal vertebrae transforma-tions which are \u223d50% penetrant in Hoxd-11\u2212\/\u2212 single mutants, revealing that functional cooperation can also occur between non-paralogous Hox gene products in axial skeleton patterning.<\/jats:p>","DOI":"10.1242\/dev.122.2.449","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T02:31:59Z","timestamp":1619404319000},"page":"449-460","source":"Crossref","is-referenced-by-count":134,"title":["Functional cooperation between the non-paralogous genes <i>Hoxa-10<\/i> and <i>Hoxd-11<\/i> in the developing forelimb and axial skeleton"],"prefix":"10.1242","volume":"122","author":[{"given":"Bertrand","family":"Favier","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, CNRS\/INSERM\/ULP, Coll\u00e8ge de France, BP 163-67404 Illkirch-Cedex, CU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo M.","family":"Rijli","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, CNRS\/INSERM\/ULP, Coll\u00e8ge de France, BP 163-67404 Illkirch-Cedex, CU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fromental-Ramain","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, CNRS\/INSERM\/ULP, Coll\u00e8ge de France, BP 163-67404 Illkirch-Cedex, CU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Fraulob","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, CNRS\/INSERM\/ULP, Coll\u00e8ge de France, BP 163-67404 Illkirch-Cedex, CU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chambon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Doll\u00e9","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, CNRS\/INSERM\/ULP, Coll\u00e8ge de France, BP 163-67404 Illkirch-Cedex, CU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1996,2,1]]},"reference":[{"key":"2025021322190277800_DEVELOP_122_2_449C1","volume-title":"Anatomie Compar\u00e9e des Mammif\u00e8res Domestiques","author":"Barone","year":"1986"},{"key":"2025021322190277800_DEVELOP_122_2_449C2","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1242\/dev.120.8.2187","article-title":"Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of Hoxd-11","volume":"120","author":"Davis","year":"1994","journal-title":"Development"},{"key":"2025021322190277800_DEVELOP_122_2_449C3","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/375791a0","article-title":"Absence of radius and ulna in mice lacking Hoxa-11 and Hoxd-11","volume":"375","author":"Davis","year":"1995","journal-title":"Nature"},{"key":"2025021322190277800_DEVELOP_122_2_449C4","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/342767a0","article-title":"Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation","volume":"342","author":"Doll\u00e9","year":"1989","journal-title":"Nature"},{"key":"2025021322190277800_DEVELOP_122_2_449C5","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/0092-8674(93)90378-4","article-title":"Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs","volume":"75","author":"Doll\u00e9","year":"1993","journal-title":"Cell"},{"key":"2025021322190277800_DEVELOP_122_2_449C6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0959-437X(05)80072-3","article-title":"Patterning in the vertebrate limb","volume":"1","author":"Duboule","year":"1991","journal-title":"Curr. 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