{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:07:28Z","timestamp":1791216448792,"version":"4.1.0"},"reference-count":69,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[1996,4,1]],"date-time":"1996-04-01T00:00:00Z","timestamp":828316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>A key event in the development of the mammalian cerebral cortex is the generation of neuronal populations during embryonic life. Previous studies have revealed many details of cortical neuron development including cell birthdates, migration patterns and lineage relationships. Programmed cell death is a potentially important mechanism that could alter the numbers and types of developing cortical cells during these early embryonic phases. While programmed cell death has been documented in other parts of the embryonic central nervous system, its operation has not been previously reported in the embryonic cortex because of the lack of cell death markers and the difficulty in following the entire population of cortical cells. Here, we have investigated the spatial and temporal distribution of dying cells in the embryonic cortex using an in situ end- labelling technique called \u2018ISEL+\u2019 that identifies fragmented nuclear DNA in dying cells with increased sensitivity. The period encompassing murine cerebral cortical neurogenesis was examined, from embryonic days 10 through 18. Dying cells were rare at embryonic day 10, but by embryonic day 14, 70% of cortical cells were found to be dying. This number declined to 50% by embryonic day 18, and few dying cells were observed in the adult cerebral cortex. Surprisingly, while dying cells were observed throughout the cerebral cortical wall, the majority were found within zones of cell proliferation rather than in regions of postmitotic neurons. These observations suggest that multiple mechanisms may regulate programmed cell death in the developing cortex. Moreover, embryonic cell death could be an important factor enabling the selection of appropriate cortical cells before they complete their differentiation in postnatal life.<\/jats:p>","DOI":"10.1242\/dev.122.4.1165","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T02:38:08Z","timestamp":1619404688000},"page":"1165-1174","source":"Crossref","is-referenced-by-count":453,"title":["Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex"],"prefix":"10.1242","volume":"122","author":[{"given":"Anne J.","family":"Blaschke","sequence":"first","affiliation":[{"name":"University of California 1 Biology Graduate Program, The Department of Pharmacology, School of Medicine , , San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Staley","sequence":"additional","affiliation":[{"name":"University of California 1 Biology Graduate Program, The Department of Pharmacology, School of Medicine , , San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerold","family":"Chun","sequence":"additional","affiliation":[{"name":"University of California 2 Neurosciences and Biomedical Sciences Graduate Program, The Department of Pharmacology, School of Medicine , , San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1996,4,1]]},"reference":[{"key":"2025021322431801500_DEVELOP_122_4_1165C1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1242\/dev.117.1.29","article-title":"Programmed cell death during Drosophila embryogenesis","volume":"117","author":"Abrams","year":"1993","journal-title":"Development"},{"key":"2025021322431801500_DEVELOP_122_4_1165C2","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1242\/dev.110.3.713","article-title":"Cellular migration patterns in the developing mouse cerebral cortex","volume":"110","author":"Austin","year":"1990","journal-title":"Development"},{"key":"2025021322431801500_DEVELOP_122_4_1165C3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0092-8674(92)90531-G","article-title":"Cell death and control of cell survival in the oligodendrocyte lineage","volume":"70","author":"Barres","year":"1992","journal-title":"Cell"},{"key":"2025021322431801500_DEVELOP_122_4_1165C4","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/0014-4886(90)90062-W","article-title":"Development of layer I and the subplate in the rat neocortex","volume":"107","author":"Bayer","year":"1990","journal-title":"Exp. Neurol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C5","volume-title":"Neocortical Development","author":"Bayer","year":"1991"},{"key":"2025021322431801500_DEVELOP_122_4_1165C6","first-page":"691","article-title":"The migration of neuroblasts in the developing cerebral cortex","volume":"99","author":"Berry","year":"1965","journal-title":"J. Anat"},{"key":"2025021322431801500_DEVELOP_122_4_1165C7","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/ar.1091660214","article-title":"Embryonic vertebrate central nervous system: revised terminology","volume":"166","author":"Committee","year":"1970","journal-title":"Anat. Rec"},{"key":"2025021322431801500_DEVELOP_122_4_1165C8","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/370220a0","article-title":"p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes","volume":"370","author":"Caelles","year":"1994","journal-title":"Nature"},{"key":"2025021322431801500_DEVELOP_122_4_1165C9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0165-3806(82)90141-9","article-title":"Neocortical histogenesis in normal and reeler mice: a developmental study based upon [3H]thymidine autoradiography","volume":"4","author":"Caviness","year":"1982","journal-title":"Dev. Brain Res"},{"key":"2025021322431801500_DEVELOP_122_4_1165C10","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0166-2236(95)93933-O","article-title":"Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model","volume":"18","author":"Caviness","year":"1995","journal-title":"Trends Neurosci"},{"key":"2025021322431801500_DEVELOP_122_4_1165C11","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0092-8674(91)90220-S","article-title":"The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system","volume":"64","author":"Chun","year":"1991","journal-title":"Cell"},{"key":"2025021322431801500_DEVELOP_122_4_1165C12","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/cne.902820407","article-title":"Interstitial cells of the adult neocortical white matter are the remnant of the early generated subplate neuron population","volume":"282","author":"Chun","year":"1989","journal-title":"J. Comp. Neurol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/cne.901670202","article-title":"The time of origin and the pattern of survival of neurons in the isthmo-optic nucleus of the chick","volume":"167","author":"Clarke","year":"1976","journal-title":"J. Comp. Neurol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C14","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1126\/science.6474175","article-title":"Regressive events in neurogenesis","volume":"225","author":"Cowan","year":"1984","journal-title":"Science"},{"key":"2025021322431801500_DEVELOP_122_4_1165C15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0165-3806(85)90238-X","article-title":"Changes in the numbers of optic nerve fibers during late prenatal and postnatal development in the albino rat","volume":"19","author":"Crespo","year":"1985","journal-title":"Dev. Brain Res"},{"key":"2025021322431801500_DEVELOP_122_4_1165C16","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0165-3806(81)90032-8","article-title":"Naturally occurring neuron death in the ganglion cell layer of the neonatal rat: morphology and evidence for regional correspondence with neuron death in superior colliculus","volume":"2","author":"Cunningham","year":"1982","journal-title":"Dev. Brain Res"},{"key":"2025021322431801500_DEVELOP_122_4_1165C17","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0022-510X(79)90115-1","article-title":"Gliogenesis and ependymogenesis during embryonic development of the rat. An autoradiographic study","volume":"43","author":"Das","year":"1979","journal-title":"J. Neur. Sci"},{"key":"2025021322431801500_DEVELOP_122_4_1165C18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/372263a0","article-title":"A self-renewing multipotential stem cell in embryonic rat cerebral cortex","volume":"372","author":"Davis","year":"1994","journal-title":"Nature"},{"key":"2025021322431801500_DEVELOP_122_4_1165C19","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/0306-4522(90)90027-2","article-title":"Cajal-Retzius cell ontogenesis and death in mouse brain visualized with horseradish peroxidase and electron mircroscopy","volume":"36","author":"Derer","year":"1990","journal-title":"Neuroscience"},{"key":"2025021322431801500_DEVELOP_122_4_1165C20","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1073\/pnas.87.7.2579","article-title":"Kinetics of mature T-cell development in the thymus","volume":"87","author":"Egerton","year":"1990","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025021322431801500_DEVELOP_122_4_1165C21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0301-0082(92)90029-E","article-title":"Cell Death and Removal in the Cerebral Cortex During Development","volume":"39","author":"Ferrer","year":"1992","journal-title":"Prog. Neurobiol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C22","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1126\/science.6828866","article-title":"Local differences in the amount of early cell death in neocortex predict adult local specializations","volume":"219","author":"Finlay","year":"1983","journal-title":"Science"},{"key":"2025021322431801500_DEVELOP_122_4_1165C23","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/jmor.1051290303","article-title":"Differentiation and degeneration in the motor horn of the foetal mouse","volume":"129","author":"Flanagan","year":"1969","journal-title":"J. Morph"},{"key":"2025021322431801500_DEVELOP_122_4_1165C24","volume-title":"DNA Repair","author":"Friedberg","year":"1985"},{"key":"2025021322431801500_DEVELOP_122_4_1165C25","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1083\/jcb.119.3.493","article-title":"Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation","volume":"119","author":"Gavrieli","year":"1992","journal-title":"J. Cell Biol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C26","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/cne.901600408","article-title":"Cell death in the development of the lateral motor column of the chick embryo","volume":"160","author":"Hamburger","year":"1975","journal-title":"J. Comp. Neurol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C27","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/jez.1401110308","article-title":"Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions","volume":"111","author":"Hamburger","year":"1949","journal-title":"J. Exp. Zool"},{"key":"2025021322431801500_DEVELOP_122_4_1165C28","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1365-2990.1983.tb00116.x","article-title":"Neuronal death in the development and aging of the cerebral cortex of the mouse","volume":"9","author":"Heumann","year":"1983","journal-title":"Neuropath. Appl. Neurobiol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C29","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1002\/ar.1091600311","article-title":"Cell migrations to the isocortex in the rat","volume":"160","author":"Hicks","year":"1968","journal-title":"Anat. Rec"},{"key":"2025021322431801500_DEVELOP_122_4_1165C30","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/cne.903450305","article-title":"Programmed cell death during the earliest stages of spinal cord development in the chick embryo: a possible means of early phenotypic selection","volume":"343","author":"Homma","year":"1994","journal-title":"J. Comp. Neurol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C31","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/cne.902630407","article-title":"Cellular degeneration and synaptogenesis in the developing retina of the rat","volume":"263","author":"Horsburgh","year":"1987","journal-title":"J. Comp. Neurol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C32","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/cne.902970309","article-title":"Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain","volume":"297","author":"Kostovic","year":"1990","journal-title":"J. Comp. Neurol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C33","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0165-3806(82)90014-1","article-title":"Loss of axons from the optic nerve of the rat during early postnatal development","volume":"255","author":"Lam","year":"1982","journal-title":"Brain Res"},{"key":"2025021322431801500_DEVELOP_122_4_1165C34","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1113\/jphysiol.1974.sp010681","article-title":"Synaptic transmission and cell death during normal ganglionic development","volume":"241","author":"Landmesser","year":"1974","journal-title":"J. Physiol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C35","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0361-9230(85)90064-4","article-title":"Developmental genetics of the retina: evidence that the pearl mutation in the mouse affects the time course of natural cell death in the ganglion cell layer","volume":"60","author":"Linden","year":"1985","journal-title":"Exp. Brain Res"},{"key":"2025021322431801500_DEVELOP_122_4_1165C36","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/0896-6273(88)90163-8","article-title":"Cell lineage in the cerebral cortex of the mouse studied in vivo and in vitro with a recombinant retrovirus","volume":"1","author":"Luskin","year":"1988","journal-title":"Neuron"},{"key":"2025021322431801500_DEVELOP_122_4_1165C37","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1084\/jem.123.3.559","article-title":"Autoradiographic analysis of lymphopoiesis and lymphocyte migration in mice bearing multiple thymus grafts","volume":"123","author":"Matsuyama","year":"1966","journal-title":"J. Exp. Med"},{"key":"2025021322431801500_DEVELOP_122_4_1165C38","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1002\/cne.902020404","article-title":"Neuronal and neuroglial responses following retinal lesions in the neonatal rats","volume":"202","author":"Miller","year":"1981","journal-title":"J. Comp. Neurol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C39","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/glia.440040205","article-title":"Ontogeny of radial and other astroglial cells in murine cerebral cortex","volume":"4","author":"Mission","year":"1991","journal-title":"Glia"},{"key":"2025021322431801500_DEVELOP_122_4_1165C40","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0166-2236(85)90175-4","article-title":"Naturally occurring cell death during neural development","volume":"8","author":"Oppenheim","year":"1985","journal-title":"Trends Neurosci"},{"key":"2025021322431801500_DEVELOP_122_4_1165C41","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev.ne.14.030191.002321","article-title":"Cell death during development of the nervous system","volume":"14","author":"Oppenheim","year":"1991","journal-title":"Ann. Rev. Neurosci"},{"key":"2025021322431801500_DEVELOP_122_4_1165C42","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/cercor\/1.6.463","article-title":"Separate progenitor cells give rise to pyramidal and nonpyramidal neurons in the rat telencephalon","volume":"1","author":"Parnavelas","year":"1991","journal-title":"Cereb. Cort"},{"key":"2025021322431801500_DEVELOP_122_4_1165C43","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/cne.902190309","article-title":"Postnatal changes in retinal ganglion cell and optic axon populations in the pigmented rat","volume":"219","author":"Perry","year":"1983","journal-title":"J. Comp. Neurol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C44","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/0165-3806(82)90013-X","article-title":"The loss of ganglion cells in the developing retina of the rat","volume":"255","author":"Potts","year":"1982","journal-title":"Brain Res"},{"key":"2025021322431801500_DEVELOP_122_4_1165C45","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/316721a0","article-title":"Regressive events in the postnatal development of association projections in the visual cortex","volume":"316","author":"Price","year":"1985","journal-title":"Nature"},{"key":"2025021322431801500_DEVELOP_122_4_1165C46","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1242\/dev.104.3.473","article-title":"Cell lineage in the rat cerebral cortex: a study using retroviral-mediated gene transfer","volume":"104","author":"Price","year":"1988","journal-title":"Development"},{"key":"2025021322431801500_DEVELOP_122_4_1165C47","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1126\/science.8235590","article-title":"Programmed cell death and the control of cell survival: lessons from the nervous system","volume":"262","author":"Raff","year":"1993","journal-title":"Science"},{"key":"2025021322431801500_DEVELOP_122_4_1165C48","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/261467a0","article-title":"Prenatal genesis of connections subserving ocular dominance in the rhesus monkey","volume":"261","author":"Rakic","year":"1976","journal-title":"Nature"},{"key":"2025021322431801500_DEVELOP_122_4_1165C49","first-page":"245","article-title":"Prenatal development of the visual system in rhesus monkey","volume":"278","author":"Rakic","year":"1977","journal-title":"Phil. Trans. R. Soc. Lond"},{"key":"2025021322431801500_DEVELOP_122_4_1165C50","article-title":"Cell culture methods and induction of differentiation of embryonal carcinoma cell lines","volume-title":"In Teratocarcinoma and Embryonic Stem Cells: A Practical Approach","author":"Rudnicki","year":"1987"},{"key":"2025021322431801500_DEVELOP_122_4_1165C51","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1126\/science.154.3749.604","article-title":"Death in embryonic systems","volume":"154","author":"Saunders","year":"1966","journal-title":"Science"},{"key":"2025021322431801500_DEVELOP_122_4_1165C52","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4615-6619-9_2","volume-title":"The role of the subplate in the development of the mammalian telencephalon","author":"Shatz","year":"1988"},{"key":"2025021322431801500_DEVELOP_122_4_1165C53","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/cne.901960208","article-title":"The genesis of efferent connections from the visual cortex of the fetal rhesus monkey","volume":"196","author":"Shatz","year":"1981","journal-title":"J. Comp. Neurol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C54","first-page":"3","article-title":"The generation and fate of thymocytes","volume":"2","author":"Shortman","year":"1990","journal-title":"Sem. Immunol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C55","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/372100a0","article-title":"T-cell apoptosis detected in situ during positive and negative selection in the thymus","volume":"372","author":"Surh","year":"1994","journal-title":"Nature"},{"key":"2025021322431801500_DEVELOP_122_4_1165C56","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1523\/JNEUROSCI.13-02-00820.1993","article-title":"Cell cycle parameters and patterns of nuclear movement in the neocortical proliferative zone of the fetal mouse","volume":"13","author":"Takahashi","year":"1993","journal-title":"J. Neurosci"},{"key":"2025021322431801500_DEVELOP_122_4_1165C57","doi-asserted-by":"publisher","first-page":"6046","DOI":"10.1523\/JNEUROSCI.15-09-06046.1995","article-title":"The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall","volume":"15","author":"Takahashi","year":"1995","journal-title":"J. Neurosci"},{"key":"2025021322431801500_DEVELOP_122_4_1165C58","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1126\/science.3137660","article-title":"Clonally related cortical cells show several migration patterns","volume":"241","author":"Walsh","year":"1988","journal-title":"Science"},{"key":"2025021322431801500_DEVELOP_122_4_1165C59","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1126\/science.8171319","article-title":"Genetic control of programmed cell death in Drosophila","volume":"264","author":"White","year":"1994","journal-title":"Science"},{"key":"2025021322431801500_DEVELOP_122_4_1165C60","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/41.1.7678025","article-title":"A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA","volume":"41","author":"Wijsman","year":"1993","journal-title":"J. Histochem. Cytochem"},{"key":"2025021322431801500_DEVELOP_122_4_1165C61","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/0092-8674(93)90457-2","article-title":"Molecular regulation of apoptosis: genetic controls on cell death","volume":"74","author":"Williams","year":"1993","journal-title":"Cell"},{"key":"2025021322431801500_DEVELOP_122_4_1165C62","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1146\/annurev.ne.11.030188.002231","article-title":"The control of neuron number","volume":"11","author":"Williams","year":"1988","journal-title":"Ann. Rev. Neurosci"},{"key":"2025021322431801500_DEVELOP_122_4_1165C63","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0165-3806(92)90150-U","article-title":"Evidence that the earliest generated cells of the murine cerebral cortex form a transient population in the subplate and marginal zone","volume":"66","author":"Wood","year":"1992","journal-title":"Brain Res"},{"key":"2025021322431801500_DEVELOP_122_4_1165C64","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/0896-6273(93)90074-2","article-title":"In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum","volume":"11","author":"Wood","year":"1993","journal-title":"Neuron"},{"key":"2025021322431801500_DEVELOP_122_4_1165C65","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/BF00315709","article-title":"Radial glia in the developing mouse cerebral cortex and hippocampus","volume":"163","author":"Woodhams","year":"1981","journal-title":"Anat. Embryol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C66","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/284555a0","article-title":"Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation","volume":"284","author":"Wyllie","year":"1980","journal-title":"Nature"},{"key":"2025021322431801500_DEVELOP_122_4_1165C67","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-94-011-6921-9_2","article-title":"Cell death: a new classification separating apoptosis from necrosis","volume-title":"In Cell Death in Biology and Pathology","author":"Wyllie","year":"1981"},{"key":"2025021322431801500_DEVELOP_122_4_1165C68","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/path.1711420112","article-title":"Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis","volume":"142","author":"Wyllie","year":"1984","journal-title":"J. Pathol"},{"key":"2025021322431801500_DEVELOP_122_4_1165C69","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/cne.902290307","article-title":"Cell death during differentiation of the retina in the mouse","volume":"229","author":"Young","year":"1984","journal-title":"J. Comp. Neurol"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/122\/4\/1165\/3069134\/develop_122_4_1165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/122\/4\/1165\/3069134\/develop_122_4_1165.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T22:43:56Z","timestamp":1739486636000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/122\/4\/1165\/39064\/Widespread-programmed-cell-death-in-proliferative"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4,1]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.122.4.1165","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4,1]]}}}