{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:01:15Z","timestamp":1791846075276,"version":"4.3.4"},"reference-count":60,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[1996,6,1]],"date-time":"1996-06-01T00:00:00Z","timestamp":833587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Gelatinase B, a matrix metalloproteinase (MMP) of high specific activity, is highly expressed and activated by mouse blastocysts in culture, and inhibition of this enzyme activity inhibits lysis of extracellular matrix (Behrendtsen, O., Alexander, C. M. and Werb, Z. (1992) Development 114, 447-456). Because gelatinase B expression is linked to invasive potential, we studied the expression of gelatinase B mRNA and protein in vivo, in implanting trophoblast giant cells, and found that it was expressed and activated during colonization of the maternal decidua. mRNAs for several other MMPs (stromelysin-1, stromelysin-3 and gelatinase A) and MMP inhibitors (TIMP-1 and TIMP-2) were expressed in the undifferentiated stroma toward the outside of the decidua, and TIMP-3 mRNA was expressed in primary and some mature decidual cells during their differentiation. Both mRNA and TIMP-3 protein were present at high concentrations transiently, and declined from 6.5 days post coitum onward, as the cells underwent apoptosis during the main period of gelatinase B expression and ectoplacental growth and expansion. To assess the function of MMPs during implantation and decidual development, we either injected a peptide hydroxamate MMP inhibitor into normal mice or studied transgenic mice over-expressing TIMP-1. In both cases, decidual length and overall size were reduced, and the embryo was displaced mesometrially. Embryo orientation was less strictly regulated in inhibitor-treated deciduae than in control deciduae. Morphogenesis and development of oil-induced deciduomas were also slowed in the presence of the inhibitor. We conclude that administration of MMP inhibitors retards decidual remodeling and growth, and we suggest that the MMPs expressed in precursor stromal cells promote their differentiation and expansion.<\/jats:p>","DOI":"10.1242\/dev.122.6.1723","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T02:43:16Z","timestamp":1619404996000},"page":"1723-1736","source":"Crossref","is-referenced-by-count":268,"title":["Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation"],"prefix":"10.1242","volume":"122","author":[{"given":"Caroline M.","family":"Alexander","sequence":"first","affiliation":[{"name":"University of California 1 Laboratory of Radiobiology and Environmental Health and Department of Anatomy , , San Francisco, California 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Hansell","sequence":"additional","affiliation":[{"name":"University of California 1 Laboratory of Radiobiology and Environmental Health and Department of Anatomy , , San Francisco, California 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Behrendtsen","sequence":"additional","affiliation":[{"name":"University of California 1 Laboratory of Radiobiology and Environmental Health and Department of Anatomy , , San Francisco, California 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret L.","family":"Flannery","sequence":"additional","affiliation":[{"name":"University of California 1 Laboratory of Radiobiology and Environmental Health and Department of Anatomy , , San Francisco, California 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerendra S.","family":"Kishnani","sequence":"additional","affiliation":[{"name":"University of California 2 Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry , , San Francisco, California 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P.","family":"Hawkes","sequence":"additional","affiliation":[{"name":"University of California 2 Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry , , San Francisco, California 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zena","family":"Werb","sequence":"additional","affiliation":[{"name":"University of California 1 Laboratory of Radiobiology and Environmental Health and Department of Anatomy , , San Francisco, California 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1996,6,1]]},"reference":[{"key":"2025021322590082300_DEVELOP_122_6_1723C1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/jez.1402660610","article-title":"Implantation and decidualization in rodents","volume":"266","author":"Abrahamsohn","year":"1993","journal-title":"J. Exp. Zool"},{"key":"2025021322590082300_DEVELOP_122_6_1723C2","first-page":"543","article-title":"Follistatin expression in ES and F9 cells and in preimplantation mouse embryos","volume":"38","author":"Albano","year":"1994","journal-title":"Int. J. Dev. Biol"},{"key":"2025021322590082300_DEVELOP_122_6_1723C3","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1083\/jcb.118.3.727","article-title":"Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro","volume":"118","author":"Alexander","year":"1992","journal-title":"J. Cell Biol"},{"key":"2025021322590082300_DEVELOP_122_6_1723C4","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/aja.1002000302","article-title":"Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10","volume":"200","author":"Apte","year":"1994","journal-title":"Dev. Dynamics"},{"key":"2025021322590082300_DEVELOP_122_6_1723C5","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1242\/dev.120.9.2539","article-title":"Platelet endothelial cell adhesion molecule-1 (PECAM-1\/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development","volume":"120","author":"Baldwin","year":"1994","journal-title":"Development"},{"key":"2025021322590082300_DEVELOP_122_6_1723C6","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1242\/dev.114.2.447","article-title":"Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths","volume":"114","author":"Behrendtsen","year":"1992","journal-title":"Development"},{"key":"2025021322590082300_DEVELOP_122_6_1723C7","first-page":"3872","article-title":"Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells","volume":"50","author":"Bernhard","year":"1990","journal-title":"Cancer Res"},{"key":"2025021322590082300_DEVELOP_122_6_1723C8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1177\/10454411930040020401","article-title":"Matrix metalloproteinases: a review","volume":"4","author":"Birkedal-Hansen","year":"1993","journal-title":"Crit. Rev. Oral. Biol. Med"},{"key":"2025021322590082300_DEVELOP_122_6_1723C9","doi-asserted-by":"publisher","first-page":"11563","DOI":"10.1016\/S0021-9258(18)90899-9","article-title":"Characterization of a transformation-sensitive protein in the extracellular matrix of chicken embryo fibroblasts","volume":"259","author":"Blenis","year":"1984","journal-title":"J. Biol. Chem"},{"key":"2025021322590082300_DEVELOP_122_6_1723C10","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1126\/science.7531366","article-title":"Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix","volume":"267","author":"Boudreau","year":"1995","journal-title":"Science"},{"key":"2025021322590082300_DEVELOP_122_6_1723C11","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/0092-8674(94)90007-8","article-title":"Integrin \u03b1v\u03b23 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels","volume":"79","author":"Brooks","year":"1994","journal-title":"Cell"},{"key":"2025021322590082300_DEVELOP_122_6_1723C12","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1210\/mend-1-11-767","article-title":"Molecular cloning and expression of mouse placental lactogen I complementary deoxyribonucleic acid","volume":"1","author":"Colosi","year":"1987","journal-title":"Mol. Endocrinol"},{"key":"2025021322590082300_DEVELOP_122_6_1723C13","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0092-8674(95)90169-8","article-title":"Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo","volume":"83","author":"Coucouvanis","year":"1995","journal-title":"Cell"},{"key":"2025021322590082300_DEVELOP_122_6_1723C14","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1126\/science.7985020","article-title":"Implantation and the placenta: Key pieces of the development puzzle","volume":"266","author":"Cross","year":"1994","journal-title":"Science"},{"key":"2025021322590082300_DEVELOP_122_6_1723C15","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1242\/dev.121.8.2513","article-title":"Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development","volume":"121","author":"Cross","year":"1995","journal-title":"Development"},{"key":"2025021322590082300_DEVELOP_122_6_1723C16","first-page":"2087","article-title":"A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts","volume":"53","author":"Davies","year":"1993","journal-title":"Cancer Res"},{"key":"2025021322590082300_DEVELOP_122_6_1723C17","first-page":"1067","article-title":"Epithelial autolysis during implantation of the mouse blastocyst: an ultrastructural study","volume":"33","author":"El-Shershaby","year":"1975","journal-title":"J. Embryol. Exp. Morphol"},{"key":"2025021322590082300_DEVELOP_122_6_1723C18","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1095\/biolreprod46.6.1095","article-title":"Differential temporal and spatial expression of mRNA encoding extracellular matrix components in decidua during the peri-implantation period","volume":"46","author":"Farrar","year":"1992","journal-title":"Biol. Reprod"},{"key":"2025021322590082300_DEVELOP_122_6_1723C19","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1242\/dev.110.2.589","article-title":"Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm","volume":"110","author":"Frohman","year":"1990","journal-title":"Development"},{"key":"2025021322590082300_DEVELOP_122_6_1723C20","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/j.1460-2075.1987.tb04804.x","article-title":"Characterization and expression of a murine gene homologous to human EPA\/TIMP: A virus-induced gene in the mouse","volume":"6","author":"Gewert","year":"1987","journal-title":"EMBO J"},{"key":"2025021322590082300_DEVELOP_122_6_1723C21","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1095\/biolreprod35.2.463","article-title":"Intermediate filament protein as a marker of uterine stromal cell decidualization","volume":"35","author":"Glasser","year":"1986","journal-title":"Biol. Reprod"},{"key":"2025021322590082300_DEVELOP_122_6_1723C22","first-page":"519","article-title":"Involvement of the proto-oncogene c-ets 1 and the urokinase plasminogen activator during mouse implantation and placentation","volume":"37","author":"Grevin","year":"1993","journal-title":"Int. J. Dev. Biol"},{"key":"2025021322590082300_DEVELOP_122_6_1723C23","doi-asserted-by":"publisher","first-page":"7152","DOI":"10.1021\/bi00146a017","article-title":"Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeroginosa elastase by peptide hydroxamic acids","volume":"31","author":"Grobelny","year":"1992","journal-title":"Biochemistry"},{"key":"2025021322590082300_DEVELOP_122_6_1723C24","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1210\/endo.135.3.8070373","article-title":"Apoptosis in decidual tissue regression and reorganization","volume":"135","author":"Gu","year":"1994","journal-title":"Endocrinology"},{"key":"2025021322590082300_DEVELOP_122_6_1723C25","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/0378-1119(92)90116-7","article-title":"Cloning and sequencing of a cDNA encoding mouse stromelysin 1","volume":"120","author":"Hammani","year":"1992","journal-title":"Gene"},{"key":"2025021322590082300_DEVELOP_122_6_1723C26","first-page":"2335","article-title":"Expression of rat transforming growth factor alpha mRNA during development occurs predominantly in the maternal decidua","volume":"7","author":"Han","year":"1987","journal-title":"Mol. Cell. Biol"},{"key":"2025021322590082300_DEVELOP_122_6_1723C27","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1242\/dev.121.4.1005","article-title":"Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor","volume":"121","author":"Harvey","year":"1995","journal-title":"Development"},{"key":"2025021322590082300_DEVELOP_122_6_1723C28","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/jez.1402660607","article-title":"Giant and binucleate trophoblast cells of mammals","volume":"266","author":"Hoffman","year":"1993","journal-title":"J. Exp. Zool"},{"key":"2025021322590082300_DEVELOP_122_6_1723C29","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1242\/dev.120.3.661","article-title":"Tenascin is induced at implantation sites in the mouse uterus and interferes with epithelial cell adhesion","volume":"120","author":"Julian","year":"1994","journal-title":"Development"},{"key":"2025021322590082300_DEVELOP_122_6_1723C30","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF00310059","article-title":"Involution of the antimesometrial decidua in the mouse. An ultrastructural study","volume":"176","author":"Katz","year":"1987","journal-title":"Anat. Embryol"},{"key":"2025021322590082300_DEVELOP_122_6_1723C31","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/jnci\/86.4.299","article-title":"Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1","volume":"86","author":"Khokha","year":"1994","journal-title":"J. Natl. Canc. Inst"},{"key":"2025021322590082300_DEVELOP_122_6_1723C32","doi-asserted-by":"publisher","first-page":"9352","DOI":"10.1016\/S0021-9258(17)37115-6","article-title":"Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues","volume":"269","author":"Leco","year":"1994","journal-title":"J. Biol. Chem"},{"key":"2025021322590082300_DEVELOP_122_6_1723C33","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1083\/jcb.113.2.437","article-title":"92-kD type IV collagenase mediates invasion of human cytotrophoblasts","volume":"113","author":"Librach","year":"1991","journal-title":"J. Cell Biol"},{"key":"2025021322590082300_DEVELOP_122_6_1723C34","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1159\/000146270","article-title":"Collagen distribution in the mouse endometrium during decidualization","volume":"127","author":"Martello","year":"1986","journal-title":"Acta Anat"},{"key":"2025021322590082300_DEVELOP_122_6_1723C35","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1172\/JCI115553","article-title":"Macrophage functions are regulated by murine decidual and tumor extracellular matrices","volume":"89","author":"McKay","year":"1992","journal-title":"J. Clin. Invest"},{"key":"2025021322590082300_DEVELOP_122_6_1723C36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0014-5793(95)00125-S","article-title":"The extracellular matrix produced by bovine corneal endothelial cells contains progelatinase A","volume":"361","author":"Menashi","year":"1995","journal-title":"FEBS Lett"},{"key":"2025021322590082300_DEVELOP_122_6_1723C37","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1091\/mbc.4.9.953","article-title":"The extracellular matrix as a cell survival factor","volume":"4","author":"Meredith","year":"1993","journal-title":"Mol. Biol. Cell"},{"key":"2025021322590082300_DEVELOP_122_6_1723C38","first-page":"5467","article-title":"Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line","volume":"54","author":"Montgomery","year":"1994","journal-title":"Cancer Res"},{"key":"2025021322590082300_DEVELOP_122_6_1723C39","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1242\/dev.105.3.575","article-title":"Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA","volume":"105","author":"Nomura","year":"1989","journal-title":"Development"},{"key":"2025021322590082300_DEVELOP_122_6_1723C40","doi-asserted-by":"publisher","first-page":"24994","DOI":"10.1016\/S0021-9258(17)31488-6","article-title":"Identification of a specific receptor for interstitial collagenase on osteoblastic cells","volume":"269","author":"Omura","year":"1994","journal-title":"J. Biol. Chem"},{"key":"2025021322590082300_DEVELOP_122_6_1723C41","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/aja.1001660304","article-title":"Ultrastructure of decidualization in the pseudopregnant rat","volume":"166","author":"O\u2019Shea","year":"1983","journal-title":"Am. J. Anat"},{"key":"2025021322590082300_DEVELOP_122_6_1723C42","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1046\/j.1432-0436.1994.5710051.x","article-title":"Immunohistochemical localization of tissue transglutaminase and Bcl-2 in rat uterine tissues during embryo implantation and post-partum involution","volume":"57","author":"Piacentini","year":"1994","journal-title":"Differentiation"},{"key":"2025021322590082300_DEVELOP_122_6_1723C43","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/0012-1606(89)90319-9","article-title":"Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis","volume":"133","author":"Regenstreif","year":"1989","journal-title":"Dev. Biol"},{"key":"2025021322590082300_DEVELOP_122_6_1723C44","doi-asserted-by":"publisher","first-page":"7856","DOI":"10.1016\/S0021-9258(18)42592-6","article-title":"Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development","volume":"267","author":"Reponen","year":"1992","journal-title":"J. Biol. Chem"},{"key":"2025021322590082300_DEVELOP_122_6_1723C45","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1083\/jcb.124.6.1091","article-title":"High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development","volume":"124","author":"Reponen","year":"1994","journal-title":"J. Cell Biol"},{"key":"2025021322590082300_DEVELOP_122_6_1723C46","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1002\/aja.1002020408","article-title":"92-kDa type IV collagenase and TIMP-3, but not 72-kDa type IV collagenase or TIMP-1 or TIMP-2, are highly expressed during mouse embryo implantation","volume":"202","author":"Reponen","year":"1995","journal-title":"Dev. Dynamics"},{"key":"2025021322590082300_DEVELOP_122_6_1723C47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/aja.1001950102","article-title":"Uterine fibronectin mRNA content and localization are modulated during implantation [published erratum appears in Dev. Dynamics 1993, 196, 234]","volume":"195","author":"Rider","year":"1992","journal-title":"Dev. Dynamics"},{"key":"2025021322590082300_DEVELOP_122_6_1723C48","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1172\/JCI117461","article-title":"Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones","volume":"94","author":"Rodgers","year":"1994","journal-title":"J. Clin. Invest"},{"key":"2025021322590082300_DEVELOP_122_6_1723C49","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/370061a0","article-title":"A matrix metalloproteinase expressed on the surface of invasive tumour cells","volume":"370","author":"Sato","year":"1994","journal-title":"Nature"},{"key":"2025021322590082300_DEVELOP_122_6_1723C50","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1095\/biolreprod12.1.41","article-title":"Cellular basis of interaction between trophoblast and uterus at implantation","volume":"12","author":"Schlafke","year":"1975","journal-title":"Biol. Reprod"},{"key":"2025021322590082300_DEVELOP_122_6_1723C51","doi-asserted-by":"publisher","first-page":"6351","DOI":"10.1074\/jbc.270.11.6351","article-title":"Activation of the 92-kDa gelatinase by stromelysin and 4-aminophenylmercuric acetate. Differential processing and stabilization of the carboxyl-terminal domain by tissue inhibitor of metalloproteinases (TIMP)","volume":"270","author":"Shapiro","year":"1995","journal-title":"J. Biol. Chem"},{"key":"2025021322590082300_DEVELOP_122_6_1723C52","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1172\/JCI117907","article-title":"VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis","volume":"95","author":"Singer","year":"1995","journal-title":"J. Clin. Invest"},{"key":"2025021322590082300_DEVELOP_122_6_1723C53","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0021-9258(18)52455-8","article-title":"The 21-kDa protein is a transformation-sensitive metalloproteinase inhibitor of chicken fibroblasts","volume":"266","author":"Staskus","year":"1991","journal-title":"J. Biol. Chem"},{"key":"2025021322590082300_DEVELOP_122_6_1723C54","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0143-4004(05)80462-X","article-title":"Distribution of \u03b12 macroglobulin and \u03b11-acid glycoprotein mRNA shows regional specialization in rat decidua","volume":"14","author":"Thomas","year":"1993","journal-title":"Placenta"},{"key":"2025021322590082300_DEVELOP_122_6_1723C55","first-page":"391","article-title":"Biology of implantation","volume-title":"In The Physiology of Reproduction","author":"Weitlauf","year":"1994"},{"key":"2025021322590082300_DEVELOP_122_6_1723C56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/aja.1001720102","article-title":"Light and electron microscopic examination of the mature decidual cells of the rat with emphasis on the antimesometrial decidua and its degeneration","volume":"172","author":"Welsh","year":"1985","journal-title":"Am. J. Anat"},{"key":"2025021322590082300_DEVELOP_122_6_1723C57","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/ar.1092170213","article-title":"Trophoblast-decidual cell interactions and establishment of maternal blood circulation in the parietal yolk sac placenta of the rat","volume":"217","author":"Welsh","year":"1987","journal-title":"Anat. Rec"},{"key":"2025021322590082300_DEVELOP_122_6_1723C58","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/aja.1001920302","article-title":"Chorioallantoic placenta formation in the rat: I. Luminal epithelial cell death and extracellular matrix modifications in the mesometrial region of implantation chambers","volume":"192","author":"Welsh","year":"1991","journal-title":"Am. J. Anat"},{"key":"2025021322590082300_DEVELOP_122_6_1723C59","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1002\/aja.1001920404","article-title":"Chorioallantoic placenta formation in the rat: II. Angiogenesis and maternal blood circulation in the mesometrial region of the implantation chamber prior to placenta formation","volume":"192","author":"Welsh","year":"1991","journal-title":"Am. J. Anat"},{"key":"2025021322590082300_DEVELOP_122_6_1723C60","doi-asserted-by":"publisher","first-page":"18953","DOI":"10.1016\/S0021-9258(17)32259-7","article-title":"A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence","volume":"269","author":"Wick","year":"1994","journal-title":"J. Biol. Chem"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/122\/6\/1723\/3069972\/develop_122_6_1723.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/122\/6\/1723\/3069972\/develop_122_6_1723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T22:59:42Z","timestamp":1739487582000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/122\/6\/1723\/39178\/Expression-and-function-of-matrix"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6,1]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,6,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.122.6.1723","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,6,1]]}}}