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A subpopulation of these projection neurons is reduced in deficient mice due to impaired migration. We demonstrate that the detected alterations in the number of mitral cells are well correlated with diminished odor discrimination ability and social long-term memory formation. Reduced neuronal activation in the olfactory bulb and the corresponding olfactory cortex suggest that TAG-1 is crucial for the olfactory circuit formation in mice. Our results underpin the significance of a numerical defect in the mitral cell layer in the processing and integration of odorant information and subsequently in animal behavior.<\/jats:p>","DOI":"10.1242\/dev.123943","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T02:53:38Z","timestamp":1446519218000},"source":"Crossref","is-referenced-by-count":14,"title":["TAG-1 deficiency results in olfactory dysfunction due to impaired migration of mitral cells"],"prefix":"10.1242","author":[{"given":"Bastakis G.","family":"George","sequence":"first","affiliation":[{"name":"Department of Basic Science, Faculty of Medicine, University of Crete and Institute of Mol. 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